Pancreatic fibroblast growth factor 21 protects against type 2 diabetes in mice by promoting insulin expression and secretion in a PI3K/Akt signaling-dependent manner.

scientific article published on 20 November 2018

Pancreatic fibroblast growth factor 21 protects against type 2 diabetes in mice by promoting insulin expression and secretion in a PI3K/Akt signaling-dependent manner. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/JCMM.14007
P932PMC publication ID6349243
P698PubMed publication ID30461198

P50authorXuebo PanQ93264228
P2093author name stringXiaokun Li
Zhichao Fan
Fanghua Gong
Saisai Zhang
Yanna Ye
Zhuofeng Lin
Yingying Pan
Chaoming Wu
Baile Wang
Jujia Zheng
Qinyao Li
Rongrong Xiong
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MiR-577 inhibits pancreatic β-cell function and survival by targeting fibroblast growth factor 21 (FGF-21) in pediatric diabetesQ38814512
FGF21 treatment ameliorates alcoholic fatty liver through activation of AMPK-SIRT1 pathwayQ38943985
Syntaxin-3 regulates newcomer insulin granule exocytosis and compound fusion in pancreatic beta cellsQ39248592
SNARE conformational changes that prepare vesicles for exocytosisQ39681959
Fibroblast growth factor-21 improves pancreatic beta-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and Akt signaling pathways.Q40239037
FGF21 analogs of sustained action enabled by orthogonal biosynthesis demonstrate enhanced antidiabetic pharmacology in rodentsQ40667176
Autofluorescence imaging of living pancreatic islets reveals fibroblast growth factor-21 (FGF21)-induced metabolism.Q41842372
Cooperation between HMGA1, PDX-1, and MafA is Essential for Glucose-Induced Insulin Transcription in Pancreatic Beta CellsQ41988656
FGF21 as an Endocrine Regulator in Lipid Metabolism: From Molecular Evolution to Physiology and PathophysiologyQ42176870
Decreased expression of t-SNARE, syntaxin 1, and SNAP-25 in pancreatic beta-cells is involved in impaired insulin secretion from diabetic GK rat islets: restoration of decreased t-SNARE proteins improves impaired insulin secretionQ42480566
Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese miceQ43224118
FGF21 Is an Exocrine Pancreas Secretagogue.Q51189900
Fıbroblast growth factor 21 and ıts relatıonshıp wıth ınsulın sensıtıvıty ın fırst-degree relatıves of patıents wıth type 2 dıabetes mellıtus.Q51288933
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In vivo activation of the PI3K-Akt pathway in mouse beta cells by the EGFR mutation L858R protects against diabetes.Q54379896
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FGF-21 as a novel metabolic regulatorQ24523933
Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1alpha pathwayQ24607012
FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation responseQ24653481
Changes in beta cell function occur in prediabetes and early disease in the Lepr (db) mouse model of diabetesQ27325700
Impaired gene and protein expression of exocytotic soluble N-ethylmaleimide attachment protein receptor complex proteins in pancreatic islets of type 2 diabetic patientsQ27863911
Natural history of β-cell adaptation and failure in type 2 diabetesQ28082002
Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemiaQ28365783
FGF21 requires βklotho to act in vivoQ28485347
pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasisQ28504532
Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic statesQ29615208
Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21Q29615209
Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetesQ29619192
The secretory deficit in islets from db/db mice is mainly due to a loss of responding beta cellsQ30580446
The importance of the beta-cell in the pathogenesis of type 2 diabetes mellitusQ33891620
Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse.Q34197301
Circulating FGF21 is liver derived and enhances glucose uptake during refeeding and overfeeding.Q34428501
The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21.Q34577053
Fibroblast growth factor 21 corrects obesity in miceQ34805555
Growth hormone induces hepatic production of fibroblast growth factor 21 through a mechanism dependent on lipolysis in adipocytesQ35266423
Fibroblast growth factor 21 prevents atherosclerosis by suppression of hepatic sterol regulatory element-binding protein-2 and induction of adiponectin in mice.Q35648897
FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesisQ35755169
Fibroblast growth factor 21 limits lipotoxicity by promoting hepatic fatty acid activation in mice on methionine and choline-deficient dietsQ36061647
Elevated Serum Fibroblast Growth Factor 21 in Humans with Acute PancreatitisQ36188382
βKlotho is required for fibroblast growth factor 21 effects on growth and metabolismQ36248720
PDX-1 and MafA play a crucial role in pancreatic beta-cell differentiation and maintenance of mature beta-cell functionQ36972355
FGF21 is an Akt-regulated myokineQ37017459
Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanismsQ37078025
High glucose represses β-klotho expression and impairs fibroblast growth factor 21 action in mouse pancreatic islets: involvement of peroxisome proliferator-activated receptor γ signalingQ37251086
Targeting β-Cell Function Early in the Course of Therapy for Type 2 Diabetes MellitusQ37782506
P433issue2
P304page(s)1059-1071
P577publication date2018-11-20
P1433published inJournal of Cellular and Molecular MedicineQ1524063
P1476titlePancreatic fibroblast growth factor 21 protects against type 2 diabetes in mice by promoting insulin expression and secretion in a PI3K/Akt signaling-dependent manner
P478volume23

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