Abstract is: Whipple's disease is a rare systemic infectious disease caused by the bacterium Tropheryma whipplei. First described by George Hoyt Whipple in 1907 and commonly considered as a gastrointestinal disorder, Whipple's disease primarily causes malabsorption, but may affect any part of the human body, including the heart, brain, joints, skin, lungs and the eyes. Weight loss, diarrhea, joint pain, and arthritis are common presenting symptoms, but the presentation can be highly variable in certain individuals, and about 15% of patients do not have the standard signs and symptoms. Whipple's disease is significantly more common in men, with 87% of patients diagnosed being male. When recognized and treated, Whipple's disease can usually be cured with long-term antibiotic therapy, but if the disease is left undiagnosed or untreated, it can ultimately be fatal.
infectious disease | Q18123741 |
class of disease | Q112193867 |
disease | Q12136 |
intestinal disease | Q3055380 |
bacterial infectious disease | Q727028 |
infectious disease of the nervous system | Q10336461 |
rare disease with myoclonus as a major feature | Q55787252 |
P1889 | different from | Whipple's triad | Q7993737 |
P828 | has cause | infection | Q166231 |
P1995 | health specialty | gastroenterology | Q120569 |
P138 | named after | George Whipple | Q273238 |
P5008 | on focus list of Wikimedia project | WikiProject Medicine | Q4099686 |
P910 | topic's main category | Category:Whipple's disease | Q32730999 |
Q56588313 | A ParadoxicalTropheryma whippleiWestern Blot Differentiates Patients with Whipple Disease from Asymptomatic Carriers |
Q72729124 | A case of Whipple disease with a pseudotumorous presentation: differential diagnosis with mesenteric panniculitis |
Q54566153 | A case of Whipple disease with pleural effusion diagnosed by means of PCR. |
Q48110890 | A case of rapidly progressive dementia: Whipple disease of CNS. |
Q41987891 | A patient with cerebral Whipple disease with gastric involvement but no gastrointestinal symptoms: a consequence of local protective immunity? |
Q38167411 | A severe Whipple disease with an immune reconstitution inflammatory syndrome: an additional case of thalidomide efficiency. |
Q85949825 | A unique posterior segment manifestation of whipple disease |
Q46577793 | Acquired resistance to trimethoprim-sulfamethoxazole during Whipple disease and expression of the causative target gene |
Q40688510 | An elderly patient with arthralgia, fever, weakness and weight loss. Diagnosis of Whipple disease by PCR detection of Tropheryma whippelii |
Q73836373 | An unusual spinal presentation of Whipple disease |
Q92212256 | Another Whipple's triad? Pericardial, myocardial and valvular disease in an unusual case presentation from a Canadian perspective |
Q73366636 | Aortic valve endocarditis with Whipple disease |
Q46150360 | Atypical presentation of Whipple disease with no diarrhea. |
Q92282493 | Author response: IgLON5-mediated neurodegeneration is a differential diagnosis of CNS Whipple disease |
Q38954025 | Bilateral panuveitis associated with Whipple disease - case report. |
Q73055224 | Cardiac Whipple disease: identification of Whipple bacillus by electron microscopy of a patient before death |
Q36009033 | Central nervous system involvement in Whipple disease: clinical study of 18 patients and long-term follow-up |
Q91749900 | Cervical myelopathy as a form of presentation of Whipple disease |
Q72714961 | Computed Tomography in Whipple Disease |
Q73514255 | Culture and immunological detection of Tropheryma whippelii from the duodenum of a patient with Whipple disease |
Q40422576 | Deep Vein Thrombosis as Initial Manifestation of Whipple Disease |
Q61053589 | Detection of a Clonal BCL2 Gene Rearrangement in Tissues from a Patient with Whipple Disease |
Q57180736 | Diagnosis and Monitoring of Whipple Disease by Polymerase Chain Reaction |
Q40521495 | Endocarditis caused by Tropheryma whippelii |
Q46582077 | Exacerbation of Whipple disease by immunosuppressants |
Q54090925 | First Moroccan case of Whipple's disease |
Q57802036 | From Whipple Disease to Tropheryma whipplei Infection |
Q36151214 | Gastrointestinal diagnosis of classical Whipple disease: clinical, endoscopic, and histopathologic features in 191 patients |
Q40254152 | Genotypic analysis of Tropheryma whipplei from patients with Whipple disease in the Americas |
Q73337575 | Granulomatous nephritis as the first manifestation of Whipple disease |
Q48487192 | Hypersomnia in Whipple disease: case report |
Q88698711 | IgLON5-mediated neurodegeneration is a differential diagnosis of CNS Whipple disease |
Q43074040 | Infection: How should classic Whipple disease be managed? |
Q62091215 | Intestinal Mycobacterium avium complex infection initially misdiagnosed and mistreated as Whipple disease |
Q83934691 | Intestinal and lymphanode involvement of Whipple's disease. One case report |
Q34983067 | Intracerebral Whipple disease: unusual location and bone destruction. Case report |
Q58866613 | Isolated CNS Whipple disease with a variant of oculofacial skeletal myorhythmia (OFSM) |
Q30578140 | Isolated CNS Whipple disease with normal brain MRI and false-positive CSF 14-3-3 protein: a case report and review of the literature. |
Q80497379 | Isolated CNS Whipple disease: acute onset and relapsing-remitting course |
Q48766553 | Isolated Whipple disease of the brain resembling a tumour |
Q97878541 | Lessons from practice Low attenuation lymphadenopathy on computed tomography leading to diagnosis of Whipple disease |
Q33556341 | MR imaging of central nervous system Whipple disease: a 15-year review |
Q71710645 | MR of cerebral Whipple disease |
Q40683395 | Masked course of Whipple disease with uveitis, infection, endocardial involvement and abdominal lymphomas--case report and review of the literature |
Q40212775 | Neurocognitive impairment in Whipple disease with central nervous system involvement |
Q36786039 | Neurologic manifestations of Whipple disease |
Q30747582 | Neurologic presentation of Whipple disease: report of 12 cases and review of the literature |
Q40571830 | Neurological manifestations of Whipple disease |
Q76378550 | Neurological manifestations of Whipple disease |
Q37125339 | Neurologically presenting Whipple disease: case report and review of the literature |
Q91330272 | Ocular Whipple Disease: Report of Three Cases |
Q71651845 | Ocular involvement in Whipple disease |
Q54124222 | Ocular manifestations of Whipple disease: an atypical presentation. |
Q67654931 | Oculo-Facial-Skeletal Myorhythmia in Whipple Disease: Treatment with Ceftriaxone |
Q89517916 | Pearls & Oy-sters: A rare presentation of Whipple disease: Still waters run deep |
Q92841018 | Potential Role for Urine Polymerase Chain Reaction in the Diagnosis of Whipple Disease |
Q49608819 | Primary Whipple disease of the CNS presenting with chorea and dystonia: A video case report |
Q92870426 | Primary Whipple disease of the Central Nervous System presenting with rhombencephalitis |
Q36111486 | Primary Whipple disease of the brain: case report with long-term clinical and MRI follow-up |
Q46165995 | Primary cerebral Whipple disease presenting as Klüver-Bucy syndrome |
Q77411282 | Primary diagnosis of whipple disease manifesting as lymphadenopathy: use of polymerase chain reaction for detection of Tropheryma whippelii |
Q92282486 | Reader response: IgLON5-mediated neurodegeneration is a differential diagnosis of CNS Whipple disease |
Q37633981 | Renal amyloidosis in Whipple disease: a case report. |
Q34531458 | Reversible pulmonary hypertension in Whipple disease: a case report with clinicopathological implications, and literature review |
Q42241979 | Rheumatic and musculoskeletal features of Whipple disease: a report of 29 cases |
Q91318611 | Seronegative Arthritis and Whipple Disease: Risk of Misdiagnosis in the Era of Biologic Agents |
Q87344316 | Specific cutaneous involvement in Whipple disease |
Q77595287 | Spinal cord involvement in CNS Whipple disease: an ongoing experience in the MR imaging era |
Q77321773 | Spinal cord involvement in CNS Whipple disease: an ongoing experience in the magnetic resonance imaging era |
Q40594794 | Successful treatment of Whipple disease diagnosed 36 years after symptom onset. |
Q48267367 | The amnesic syndrome of primary Whipple disease of the brain |
Q69032785 | The evolving natural history of neurologic involvement in Whipple disease: a hypothesis |
Q34153566 | The immune reconstitution inflammatory syndrome in whipple disease: a cohort study |
Q53202601 | Treated Whipple disease with erythema nodosum leprosum-like lesions: cutaneous PAS-positive macrophages slowly decrease with time and are associated with lymphangiectases: a case report. |
Q76372200 | Treatment of Whipple disease |
Q77732572 | Treatment of refractory Whipple disease with interferon-gamma |
Q30657398 | Tropheryma whippelii, an emerging intracellular pathogen causing Whipple disease |
Q52639284 | Tropheryma whipplei Infection (Whipple Disease) in the USA. |
Q40421981 | Tropheryma whipplei and Whipple disease: false positive PCR detections of Tropheryma whipplei in diagnostic samples are rare |
Q37335067 | Tropheryma whipplei endocarditis |
Q46602262 | Unusual cerebral manifestation of Whipple disease |
Q90466932 | Unusual effectiveness of systemic steroids in Whipple disease |
Q44734196 | Value of Tropheryma whipplei quantitative polymerase chain reaction assay for the diagnosis of Whipple disease: usefulness of saliva and stool specimens for first-line screening |
Q95781662 | Whipple Disease Presenting as Cystic Brain Tumor: Case Report and Review of the Literature |
Q97562870 | Whipple Disease and Ankylosing Spondylitis-A Case Report |
Q48457705 | Whipple disease a century after the initial description: increased recognition of unusual presentations, autoimmune comorbidities, and therapy effects |
Q92134862 | Whipple disease after bariatric surgery: from malabsorption to malnutrition status |
Q34124993 | Whipple disease and arthritis |
Q43613884 | Whipple disease and non-Hodgkin lymphoma |
Q35215159 | Whipple disease associated with giardiasis |
Q48930079 | Whipple disease confined to the central nervous system in childhood |
Q38946159 | Whipple disease confined to the central nervous system presenting as a cystic tumor: Case report and review of literature |
Q35862493 | Whipple disease confined to the central nervous system presenting as a solitary frontal tumor. Case report |
Q96638074 | Whipple disease diagnosed by enteroscopy: first case report in Colombia of an underdiagnosed disease and literature review |
Q38074069 | Whipple disease diagnosed with PCR using formalin-fixed paraffin-embedded specimens of the intestinal mucosa |
Q54307900 | Whipple disease mimicking adult-onset Still's disease and treated by anakinra: diagnosis using PCR. |
Q96948221 | Whipple disease mimicking inflammatory bowel disease |
Q72650822 | Whipple disease of the CNS |
Q73919831 | Whipple disease of the central nervous system |
Q48518387 | Whipple disease of the central nervous system: an unusual occurrence in association with acquired immune deficiency syndrome |
Q67658542 | Whipple disease of the mediastinum |
Q48942309 | Whipple disease of the nervous system |
Q74820129 | Whipple disease presenting as posterior uveitis without prominent gastrointestinal symptoms |
Q42577126 | Whipple disease research accelerates |
Q40266108 | Whipple disease revealed by anti-TNFα therapy |
Q34279181 | Whipple disease revealed by lung involvement: a case report and literature review |
Q81363840 | Whipple disease revealed by musculocutaneous symptoms, with muscle biopsy cultures positive for Tropheryma whipplei |
Q79227297 | Whipple disease revealed by weight loss and neurologic signs |
Q79250765 | Whipple disease revisited: radiographic features of a patient with 35 years of undiagnosed arthritis |
Q54292937 | Whipple disease with crystalline keratopathy and chronic uveitis. |
Q77893380 | Whipple disease with supranuclear ophthalmoplegia diagnosed by polymerase chain reaction of cerebrospinal fluid |
Q44102627 | Whipple disease, initially diagnosed as sarcoidosis |
Q99209380 | Whipple disease: a 15-year retrospective study on 36 patients with positive polymerase chain reaction for Tropheryma whipplei |
Q36172502 | Whipple disease: a case report and review of the literature |
Q40667462 | Whipple disease: a differential diagnosis of polyarthritis to keep in mind |
Q41665049 | Whipple disease: a single or multiple origin? |
Q72752910 | Whipple disease: clinical and immunohistologic findings in 2 cases |
Q67658430 | Whipple disease: early diagnosis based on articular pathology |
Q54638166 | Whipple disease: intestinal infiltrating cells exhibit a transcriptional pattern of M2/alternatively activated macrophages. |
Q70024301 | Whipple disease: light and electron microscopy study |
Q37185875 | Whipple disease: unusual presentation of a protean and sometimes confusing disease. |
Q42026330 | Whipple's disease apropos of a case |
Q26799217 | Whipple's disease diagnosed during anti-tumor necrosis factor alpha treatment: two case reports and review of the literature |
Q91070302 | Wither Away: Weight Loss and Persistent Inflammation in a Woman With Whipple Disease |
Q53791816 | [2 cases of Whipple disease with different outcomes] |
Q71658908 | [A case of Whipple disease] |
Q68997373 | [Arterial thromboses as a complication of Whipple disease] |
Q63363782 | [Bacterium with camouflage: the genome of the pathogen of Whipple disease is not decoded] |
Q69019457 | [Behçet disease, Whipple disease and arthritis following gastrointestinal bypass operations] |
Q81517667 | [Cerebral Whipple disease without gastrointestinal symptoms] |
Q83807194 | [Chylous ascites secondary to Whipple disease] |
Q75344195 | [Diagnosis of Whipple disease by polymerase chain reaction technique] |
Q73744516 | [Diagnostic quiz. Diarrhea and muscle weakness. Whipple disease] |
Q71264931 | [Infectious origin of Whipple disease] |
Q74431415 | [Observation in two cases of Whipple disease] |
Q71686964 | [Successful therapy of cerebral Whipple disease with rifampicin] |
Q77616913 | [Uveitis in Whipple disease: Identification of Trophyrema whippelii by PCR] |
Q81315308 | [Whipple disease and central nervous system] |
Q81479990 | [Whipple disease as a cause of fever of unknown origin] |
Q77227852 | [Whipple disease associated with pulmonary arterial hypertension. Jarisch-Herxheimer reaction after antibiotic therapy] |
Q85263220 | [Whipple disease in a patient under anti-TNFα therapy] |
Q64051036 | [Whipple disease with negative duodenal histology--a case report and review of the literature] |
Q7993737 | Whipple's triad | different from | P1889 |
Q32730999 | Category:Whipple's disease | category's main topic | P301 |
Arabic (ar / Q13955) | داء ويبل | wikipedia |
az | Uippl xəstəliyi | wikipedia |
Catalan (ca / Q7026) | Malaltia de Whipple | wikipedia |
Whippleova choroba | wikipedia | |
Morbus Whipple | wikipedia | |
Whipple's disease | wikipedia | |
Enfermedad de Whipple | wikipedia | |
Basque language (eu / Q8752) | Whippleren gaitz | wikipedia |
Persian (fa / Q9168) | بیماری ویپل | wikipedia |
Whipplen tauti | wikipedia | |
Maladie de Whipple | wikipedia | |
Whipple-kór | wikipedia | |
Ուիպլի հիվանդություն | wikipedia | |
Penyakit Whipple | wikipedia | |
Malattia di Whipple | wikipedia | |
Morbus Whippleianus | wikipedia | |
Penyakit Whipple | wikipedia | |
Ziekte van Whipple | wikipedia | |
Choroba Whipple’a | wikipedia | |
Doença de Whipple | wikipedia | |
Болезнь Уиппла | wikipedia | |
Whippleho choroba | wikipedia | |
Whipplova bolezen | wikipedia | |
Виплова болест | wikipedia | |
Whipples sjukdom | wikipedia | |
ta | விப்பிள் நோய் | wikipedia |
Whipple hastalığı | wikipedia | |
Tatar language (tt / Q25285) | Уиппл чире | wikipedia |
uz | Uippl kasalligi | wikipedia |
惠普尔病 | wikipedia |
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