Inhibitory effects on lipid metabolism in cultured cells of ML-236B, a potent inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme-A reductase

scientific article published on June 15, 1978

Inhibitory effects on lipid metabolism in cultured cells of ML-236B, a potent inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme-A reductase is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/J.1432-1033.1978.TB12380.X
P698PubMed publication ID668696

P2093author name stringA. Endo
Y. Hazama-Shimada
I. Kaneko
P2860cites workML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogenesis produced by Penicillium citriniumQ28140305
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectlipid metabolismQ2792936
statinQ954845
P304page(s)313-321
P577publication date1978-06-01
1978-06-15
P1433published inFEBS JournalQ1388041
P1476titleInhibitory effects on lipid metabolism in cultured cells of ML-236B, a potent inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme-A reductase
P478volume87

Reverse relations

cites work (P2860)
Q7019301619 Receptor-mediated endocytosis of low-density lipoprotein in cultured cells
Q710122663-Hydroxy-3-methylglutaryl-CoA reductase inhibitors
Q34022421A historical perspective on the discovery of statins
Q36206948A study of the Influence of mevalonic acid and its metabolites on the morphology of swiss 3T3 cells
Q71144221Altered sterol synthesis and its relationship to fluid-phase endocytosis in a macrophage cell line P388D1
Q44006952An acidic fibroblast growth factor-like factor secreted into the brain cell culture medium upregulates apoE synthesis, HDL secretion and cholesterol metabolism in rat astrocytes.
Q68368986Antischistosomal action of mevinolin: evidence that 3-hydroxy-methylglutaryl-coenzyme a reductase activity in Schistosoma mansoni is vital for parasite survival
Q36282670Appearance of crystalloid endoplasmic reticulum in compactin-resistant Chinese hamster cells with a 500-fold increase in 3-hydroxy-3-methylglutaryl-coenzyme A reductase
Q72911813Biochemical Characterization of Skin Fibroblasts Derived from WHHL-Rabbit, a Notable Animal Model for Familial Hypercholesterolemia
Q36215149Biogenesis of the crystalloid endoplasmic reticulum in UT-1 cells: evidence that newly formed endoplasmic reticulum emerges from the nuclear envelope
Q28611253Biosynthesis of Ubiquinone
Q41578279Blockade of mevalonate production by lovastatin attenuates bombesin and vasopressin potentiation of nutrient-induced insulin secretion in HIT-T15 cells. Probable involvement of small GTP-binding proteins.
Q69963153Cellular distribution of cholesterogenesis-linked, phosphoisoprenylated proteins in proliferating cells
Q39655075Chemistry, biochemistry, and pharmacology of HMG-CoA reductase inhibitors
Q53452219Chemoprevention by pravastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, of N-methyl-N-nitrosourea-induced colon carcinogenesis in F344 rats.
Q36982518Cholesterol-lowering effect of mevinolin, an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme a reductase, in healthy volunteers
Q40273829Desialized Low-Density Lipoprotein Regulates Cholesterol Metabolism in Receptor-Deficient Fibroblasts
Q36433762Differential regulation of HMG-CoA reductase and Insig-1 by enzymes of the ubiquitin-proteasome system.
Q37478484Effect of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibition on human gut mucosa
Q43470332Effect of lovastatin on intimal hyperplasia after balloon angioplasty: A study in an atherosclerotic hypercholesterolemic rabbit
Q68029744Effect of mevinolin on rat hepatocytes: a morphometric study
Q72926566Effect of platelet-derived and endothelial cell-derived growth factors on the low density lipoprotein receptor pathway in cultured human fibroblasts
Q44357934Effect of rice--glycerol complex medium on the production of Lovastatin by Monascus ruber
Q36999320Effects of ML-236B (Compactin) on Sterol Synthesis and Low Density Lipoprotein Receptor Activities in Fibroblasts of Patients with Homozygous Familial Hypercholesterolemia
Q42484018Effects of endogenous and exogenous cholesterol on the ultrastructure and steroid secretion of undifferentiated rat adrenocortical cells in primary culture
Q73356327Effects of hydroxymethylglutaryl coenzyme A reductase inhibitor simvastatin on smooth muscle cell proliferation in vitro and neointimal formation in vivo after vascular injury
Q34036343Essential role for mevalonate synthesis in DNA replication
Q37739922Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation
Q37024891Feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in livers of mice treated with mevinolin, a competitive inhibitor of the reductase
Q41847865Human lamin B contains a farnesylated cysteine residue
Q34636105Hypolipidemic effects in dogs of ML-236B, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme a reductase
Q34512091Hypolipidemic effects in monkeys of ML-236B, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase
Q40612573Hypolipidemic, anti-obesity, anti-inflammatory, anti-osteoporotic, and anti-neoplastic properties of amine carboxyboranes
Q34266912Increase in membrane cholesterol: a possible trigger for degradation of HMG CoA reductase and crystalloid endoplasmic reticulum in UT-1 cells
Q87331004Inhibition of HMG-CoA reductase by MFS, a purified extract from the fermentation of marine fungus Fusarium solani FG319, and optimization of MFS production using response surface methodology
Q104838364Inhibition of Trichothecin and Ergosterol Biosynthesis inTrichothecium roseumby Lovastatin
Q40231567Inhibition of cholesterol synthesis with compactin renders growth of cultured cells dependent on the low density lipoprotein receptor
Q46225242Interrelationships between mevalonate metabolism and the mitogenic signaling pathway in T lymphocyte proliferation
Q70797634Isolation and characterization of cells resistant to ML236B (compactin) with increased levels of 3-hydroxy-3-methylglutaryl coenzyme A reductase
Q36409956Isopentenyladenine as a mediator of mevalonate-regulated DNA replication
Q40642726Isoprenoid pathway activity is required for IgE receptor-mediated, tyrosine kinase-coupled transmembrane signaling in permeabilized RBL-2H3 rat basophilic leukemia cells
Q35882448Isoprenoids: remarkable diversity of form and function
Q46896932Lipid-lowering effects of ethyl 2-phenacyl-3-aryl-1H-pyrrole- 4-carboxylates in rodents
Q67988304Lovastatin is hypertriglyceridemic in Syrian golden hamsters
Q41014201Mechanism of action of probucol on cholesteryl ester transfer protein (CETP) mRNA in a Chinese hamster ovary cell line that had been stably transfected with a human CETP gene
Q33566705Mevastatin blockade of autolysosome maturation stimulates LBH589-induced cell death in triple-negative breast cancer cells
Q24613185Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent
Q28367627Neutrophils are required for the DNA synthetic response of human lymphocytes to mevalonic acid: evidence suggesting that a nonsterol product of mevalonate is involved
Q36235409Oocyte activation and passage through the metaphase/anaphase transition of the meiotic cell cycle is blocked in clams by inhibitors of HMG-CoA reductase activity
Q37606011Overproduction of a Mr 92,000 protomer of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in compactin-resistant C100 cells
Q53861547Regulation of 3-hydroxy-3-methylglutaryl-CoA reductase by endogenous sterol synthesis in cultured intestinal mucosa
Q69421897Relationship of cholesterolgenesis to DNA synthesis and proliferation by lens epithelial cells in culture
Q43521139Simvastatin but not pravastatin inhibits the proliferation of rat aorta myocytes
Q36806626Statin therapy and plasma free fatty acids: a systematic review and meta-analysis of controlled clinical trials.
Q37799035Statins: A Potential Therapeutic Addition to Treatment for Aneurysmal Subarachnoid Hemorrhage?
Q34563781Suppression of murine neuroblastoma growth in vivo by mevinolin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase
Q34404997Synergic effect of eicosapentaenoic acid and lovastatin on gene expression of HMGCoA reductase and LDL receptor in cultured HepG2 cells
Q40093390Synergistic antiproliferative effects of gamma-tocotrienol and statin treatment on mammary tumor cells
Q37981833Targeting tumor cell metabolism with statins.
Q40327227The contribution of the cholesterol biosynthetic pathway to intermediary metabolism and cell function
Q40318167The role of phosphorylated dolichols in membrane glycoprotein biosynthesis: relation to cholesterol biosynthesis
Q41901294Treatment of hypercholesterolemia with the HMG CoA reductase inhibitor, simvastatin

Search more.