Characterization of the structure-activity relationships of rat types I and II 3 beta-hydroxysteroid dehydrogenase/delta 5 -delta 4 isomerase by site-directed mutagenesis and expression in HeLa cells

scientific article published on August 15, 1991

Characterization of the structure-activity relationships of rat types I and II 3 beta-hydroxysteroid dehydrogenase/delta 5 -delta 4 isomerase by site-directed mutagenesis and expression in HeLa cells is …
instance of (P31):
scholarly articleQ13442814

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P953full work available at URLhttp://intl.jbc.org/cgi/content/abstract/266/23/14842
https://api.elsevier.com/content/article/PII:S0021925818985480?httpAccept=text/plain
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P698PubMed publication ID1831194

P50authorJacques SimardQ64516110
P2093author name stringF. Labrie
Y. de Launoit
P2860cites workA rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingQ25938984
Structure and sexual dimorphic expression of a liver-specific rat 3 beta-hydroxysteroid dehydrogenase/isomeraseQ28570734
Analysis of membrane and surface protein sequences with the hydrophobic moment plotQ29618183
Characterization of macaque 3 beta-hydroxy-5-ene steroid dehydrogenase/delta 5-delta 4 isomerase: structure and expression in steroidogenic and peripheral tissues in primateQ33587551
Full length cDNA structure and deduced amino acid sequence of human 3 beta-hydroxy-5-ene steroid dehydrogenaseQ34543736
Molecular cloning, cDNA structure and predicted amino acid sequence of bovine 3 beta-hydroxy-5-ene steroid dehydrogenase/delta 5-delta 4 isomeraseQ35635695
IntracrinologyQ37124969
Metabolism of dehydroepiandrosterone by hormone dependent and hormone independent human breast carcinomaQ39965429
Cytogenetics and Cell GeneticsQ45134122
The prediction of transmembrane protein sequences and their conformation: an evaluation.Q52493577
A conformational preference parameter to predict helices in integral membrane proteins.Q52648304
The detection and classification of membrane-spanning proteins.Q52669730
Inhibitory effect of synthetic progestins, 4-MA and cyanoketone on human placental 3 beta-hydroxysteroid dehydrogenase/5----4-ene-isomerase activityQ68644942
Localization of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase in rat gonads and adrenal glands by immunocytochemistry and in situ hybridizationQ68889293
Metabolism of androgens in human hyperplastic prostate: evidence for a differential localization of the enzymes involved in the metabolismQ69131397
Neurosteroids: biosynthesis of pregnenolone and progesterone in primary cultures of rat glial cellsQ69749125
Purification and characterization of rat adrenal 3 beta-hydroxysteroid dehydrogenase with steroid 5-ene-4-ene-isomeraseQ69993327
Sequential changes in rat thymus after the subcutaneous injection of cortisolQ72786274
P4510describes a project that usessite-directed mutagenesisQ2642668
P433issue23
P407language of work or nameEnglishQ1860
P921main subjectbiochemistryQ7094
cell biologyQ7141
P1104number of pages4
P304page(s)14842-14845
P577publication date1991-08-01
1991-08-15
P1433published inJournal of Biological ChemistryQ867727
P1476titleCharacterization of the structure-activity relationships of rat types I and II 3 beta-hydroxysteroid dehydrogenase/delta 5 -delta 4 isomerase by site-directed mutagenesis and expression in HeLa cells
P478volume266

Reverse relations

cites work (P2860)
Q345666443βHSD and CYB5A double positive adrenocortical cells during adrenal development/aging
Q34723839Human adrenal cells that express both 3β-hydroxysteroid dehydrogenase type 2 (HSD3B2) and cytochrome b5 (CYB5A) contribute to adrenal androstenedione production
Q35013689Human hydroxysteroid dehydrogenases and pre-receptor regulation: insights into inhibitor design and evaluation.
Q24793533Mitochondrial 3 beta-hydroxysteroid dehydrogenase (HSD) is essential for the synthesis of progesterone by corpora lutea: an hypothesis
Q24642693Regulation of the adrenal androgen biosynthesis

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