Selective loss of cerebral cortical Sigma, but not PCP binding sites in schizophrenia

scientific article published on 01 January 1991

Selective loss of cerebral cortical Sigma, but not PCP binding sites in schizophrenia is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/0006-3223(91)90209-5
P953full work available at URLhttps://api.elsevier.com/content/article/PII:0006322391902095?httpAccept=text/plain
https://api.elsevier.com/content/article/PII:0006322391902095?httpAccept=text/xml
P698PubMed publication ID1848113

P2093author name stringJ. E. Kleinman
M. F. Casanova
E. B. De Souza
E. D. London
A. D. Weissman
P2860cites workProtein measurement with the Folin phenol reagentQ20900776
Differential regulation of sigma and PCP receptors after chronic administration of haloperidol and phencyclidine in miceQ28342521
LIGAND: A versatile computerized approach for characterization of ligand-binding systemsQ29547346
Schizophrenia and the frontal lobeQ38201347
Dopamine receptors and the dopamine hypothesis of schizophreniaQ39471744
Cerebellar pathology in schizophrenia--cause or consequence?Q40328600
Characterization of specific sigma opiate/phencyclidine (PCP)-binding sites in the human brain.Q41452704
Evidence for a role of haloperidol-sensitive sigma-'opiate' receptors in the motor effects of antipsychotic drugsQ41773246
Selective sigma receptor agonist and antagonist affect dopamine neuronal activityQ42190130
A postmortem study of the effect of chronic opiate abuse on psychotomimetic binding sites of human frontal cortexQ42200097
Autoradiographic localization of sigma receptor binding sites in guinea pig and rat central nervous system with (+)3H-3-(3-hydroxyphenyl)-N-(1-propyl)piperidineQ42205824
Phencyclidine-induced psychosisQ43637366
An endogenous ligand for the sigma opioid binding siteQ44343561
Endogenous ligands for sigma opioid receptors in the brain ("sigmaphin"): evidence from binding assaysQ44346851
Chronic haloperidol treatment up-regulates rat brain PCP receptorsQ44821781
Postmortem evidence of structural brain changes in schizophrenia. Differences in brain weight, temporal horn area, and parahippocampal gyrus compared with affective disorderQ45297275
Autoradiographic distribution of non-dopaminergic binding sites labeled by [3H]haloperidol in rat brainQ45351501
Pharmacological characteristics and distributions of sigma- and phencyclidine receptors in the animal kingdomQ46166588
Alterations in local cerebral glucose utilization induced by phencyclidineQ48177017
High correlation between the localization of [3H]TCP binding and NMDA receptorsQ48355489
Basal ganglia and limbic system pathology in schizophrenia. A morphometric study of brain volume and shrinkageQ48465361
The effects of phencyclidine and N-allylnormetazocine on midbrain dopamine neuronal activityQ48622361
An anatomy of schizophrenia?Q48642309
[3H]TCP: a new tool with high affinity for the PCP receptor in rat brainQ48713443
Phenomenological correlates of metabolic activity in 18 patients with chronic schizophrenia.Q50802287
Respiratory and subjective effects of dand l-pentazocine.Q51340760
(3H]MK-801 binding sites in postmortem brain regions of schizophrenic patientsQ57781184
Gross Pathology of the Cerebellum in Patients Diagnosed and Treated as Functional Psychiatric DisordersQ67019409
Clinical management of the phencyclidine psychosisQ67832361
Characterization of L-glutamate action on the release of endogenous dopamine from the rat caudate-putamenQ69367663
Regulation of sigma-receptors: high- and low-affinity agonist states, GTP shifts, and up-regulation by rimcazole and 1,3-Di(2-tolyl)guanidineQ69372635
Prenatal developmental disturbances in the limbic allocortex in schizophrenicsQ69518888
Sigma receptors negatively modulate agonist-stimulated phosphoinositide metabolism in rat brainQ69835434
Sigma and PCP receptors in human frontal cortex membranesQ69850247
Subjective effects of narcotic antagonists cyclazocine and nalorphine on the Addiction Research Center Inventory (ARCI)Q69924684
Activation of the A10 mesolimbic system by the sigma-receptor agonist (+)SKF 10,047 can be blocked by rimcazole, a novel putative antipsychoticQ69925850
Novel antipsychotic drugs share high affinity for sigma receptorsQ69930877
Schizoaffective psychosis. I. Comparative long-term outcomeQ70326603
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectschizophreniaQ41112
P304page(s)41-54
P577publication date1991-01-01
P1433published inBiological PsychiatryQ4914961
P1476titleSelective loss of cerebral cortical sigma, but not PCP binding sites in schizophrenia
Selective loss of cerebral cortical Sigma, but not PCP binding sites in schizophrenia
P478volume29

Reverse relations

cites work (P2860)
Q41581748A two-process theory of schizophrenia: evidence from studies in post-mortem brain
Q48922742Amino acid residues in the transmembrane domain of the type 1 sigma receptor critical for ligand binding
Q48241999An increase of sigma receptors in the aged monkey brain
Q77700428Association between polymorphisms in the type 1 sigma receptor gene and schizophrenia
Q37559277Asymmetric Synthesis of Spirocyclic 2-Benzopyrans for Positron Emission Tomography of σ1 Receptors in the Brain
Q41289597Basis of the antiseizure action of phenytoin
Q58732614Cannabidiol enhances morphine antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor
Q33921280Current hypotheses on sigma receptors and their physiological role: possible implications in psychiatry
Q38244707Development of (18)F-labeled radiotracers for neuroreceptor imaging with positron emission tomography
Q41389291Dopaminergic sensitization: implications for the pathogenesis of schizophrenia
Q78228755Electrophysiological effects of E-5842, a sigma1 receptor ligand and potential atypical antipsychotic, on A9 and A10 dopamine neurons
Q34007801Fluvoxamine alleviates ER stress via induction of Sigma-1 receptor
Q28184848Generation and phenotypic analysis of sigma receptor type I (σ1) knockout mice
Q48245172Glutamate receptors, microtubule associated proteins and developmental anomaly in schizophrenia: an hypothesis.
Q73195199In vivo evaluation of [18F]1-(3-fluoropropyl)-4-(4-cyanophenoxymethyl)piperidine: a selective sigma-1 receptor radioligand for PET
Q73428054In vivo regulation of serotonin 5-HT2A receptors in rat brain by subchronic administration of sigma receptor ligand NE-100
Q89723642Less NMDA Receptor Binding in Dorsolateral Prefrontal Cortex and Anterior Cingulate Cortex Associated with Reported Early Life Adversity but Not Suicide
Q48915313Mapping of CNS sigma(1) receptors in the conscious monkey: preliminary PET study with [(11)C]SA4503.
Q30428213Molecular aspects of glutamate dysregulation: implications for schizophrenia and its treatment
Q43774253Multiple pathways of sigma(1) receptor ligand uptakes into primary cultured neuronal cells
Q73294148Neuroleptic binding to sigma receptors: possible involvement in neuroleptic-induced acute dystonia
Q47951456Neuropeptide Y-mediated enhancement of NMDA-stimulated [3H]dopamine release from rat prefrontal cortex is reversed by sigma1 receptor antagonists
Q40932666Neurotransmitter systems in schizophrenia.
Q40524584New approaches to the drug treatment of schizophrenia
Q24792449No association between the sigma receptor type 1 gene and schizophrenia: results of analysis and meta-analysis of case-control studies
Q48544128Pharmacological comparison of the sigma recognition site labelled by [3H]haloperidol in human and rat cerebellum
Q36848319Postsynaptic density levels of the NMDA receptor NR1 subunit and PSD-95 protein in prefrontal cortex from people with schizophrenia
Q44494959Preclinical acute toxicity studies and rodent-based dosimetry estimates of the novel sigma-1 receptor radiotracer [(18)F]FPS.
Q44438932Repeated administration of the novel antipsychotic olanzapine does not modulate NMDA-sensitive glutamate and 5HT2 serotonin receptors in rats
Q74147621Repeated haloperidol treatment decreases sigma(1) receptor binding but does not affect its mRNA levels in the guinea pig or rat brain
Q34046060Reviewing the ketamine model for schizophrenia
Q67487043Sigma (σ) antagonist BMY 14802 prevents methamphetamine-induced sensitization
Q48429016Sigma receptors in schizophrenic cerebral cortices
Q28266963Sigma receptors: biology and therapeutic potential
Q44454363Sigma1 and dopamine D2 receptor occupancy in the mouse brain after a single administration of haloperidol and two dopamine D2-like receptor ligands
Q47756273Structure-Activity Relationships within a Series of σ1 and σ2 Receptor Ligands: Identification of a σ2 Receptor Agonist (BS148) with Selective Toxicity against Metastatic Melanoma.
Q51076938Synthesis, σ receptor affinity, and pharmacological evaluation of 5-phenylsulfanyl- and 5-benzyl-substituted tetrahydro-2-benzazepines.
Q34795242Targeting ligand-operated chaperone sigma-1 receptors in the treatment of neuropsychiatric disorders
Q38262682The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders
Q51750311The calcium-sensitive Sigma-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases.
Q50134834The delayed effects of DTG and MK-801 on latent inhibition in a conditioned taste-aversion paradigm
Q73093995The involvement of sigma receptors in the choice reaction performance deficits induced by phencyclidine
Q36653400The sigma-1 receptor: roles in neuronal plasticity and disease
Q48656155Uncompetitive inhibition of [3H]1,3-di-o-tolyl-guanidine-defined sigma binding sites by desipramine, propranolol and alprenolol in rat brain

Search more.