Influence of smoking and gender on the disposition kinetics of metoprolol

scientific article published on 01 January 1987

Influence of smoking and gender on the disposition kinetics of metoprolol is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/BF00637630
P698PubMed publication ID3443140

P2093author name stringL J Schaaf
S C Campbell
D G Perrier
M B Mayersohn
T Vagedes
P2860cites workPlasma Concentrations and Beta-Blocking Effects in Normal Volunteers After Intravenous Doses of Metoprolol and PropranololQ72623022
Noncompartmental Determination of the Steady‐State Volume of DistributionQ34218917
Metoprolol metabolism and debrisoquine oxidation polymorphism--population and family studiesQ34447046
The effect of age on the pharmacokinetics of metoprolol and its metabolitesQ34448597
Effects of age and smoking on the pharmacokinetics of pindolol and propranololQ34450364
Plasma metoprolol concentrations in young, old and hypertensive subjectsQ34515719
The polymorphic oxidation of beta-adrenoceptor antagonists. Clinical pharmacokinetic considerationsQ39422300
Influence of Sex on Drug Kinetics in ManQ39635992
Role of tobacco smoking in pharmacokineticsQ39723934
Influence of Cigarette Smoking on Drug Metabolism in ManQ39808606
Sex-related differences in drug metabolismQ39875025
Sex-Related Differences in Drug Disposition in ManQ40179654
Smoking and drug metabolismQ40333041
The biological properties of the optical isomers of propranolol and their effects on cardiac arrhythmiasQ41357289
Differential stereoselective metabolism of metoprolol in extensive and poor debrisoquin metabolizersQ41588910
Effects of age and cigarette smoking on propranolol dispositionQ41617556
Defective metabolism of metoprolol in poor hydroxylators of debrisoquineQ41760769
Pharmacokinetic studies on the selective beta1-receptor antagonist metoprolol in man.Q43712645
Commentary: a physiological approach to hepatic drug clearanceQ43996648
Estimation of variance for harmonic mean half-lives.Q52676346
Smoking and clinical drug effects.Q52721981
Noncompartmental determination of the steady-state volume of distribution for any mode of administration.Q52724350
Statistical moments in pharmacokinetics.Q52783431
Combined pharmacokinetic and pharmacodynamic studies in man of the adrenergic β1-receptor antagonist metoprolol *Q66896112
Pharmacokinetics of propranolol in normal healthy volunteersQ67595372
Interindividual variation of beta-adrenoceptor blocking drugs, plasma concentration and effect: influence of genetic status on behaviour of atenolol, bopindolol and metoprololQ69860504
Debrisoquine polymorphism and the metabolism and action of metoprolol, timolol, propranolol and atenololQ69885363
On the significance of host factors that affect drug dispositionQ70263992
The disposition of propranolol. I. Elimination during oral absorption in manQ70440090
The Effect of Hypoxia and Carbon Monoxide Exposure on Plasma Volume and Capillary Permeability to AlbuminQ70481756
Oxidation phenotype--a major determinant of metoprolol metabolism and responseQ70522358
Variable first-pass elimination of propranolol following single and multiple oral doses in hypertensive patientsQ70599280
Pharmacokinetics of metoprolol in healthy, elderly, non-smoking individuals after a single dose and two weeks of treatmentQ70672025
Effect of smoking on the elimination of propranolol hydrochlorideQ70684646
Bioavailability of metoprolol in young adults and the elderly, with additional studies on the effects of metoclopramide and probanthineQ71066595
Dose-dependent disposition of oral propranolol in normal subjectsQ71430802
Pharmacokinetics of metoprolol and its metabolite alpha-OH-metoprolol in healthy, non-smoking, elderly individualsQ71705871
Pharmacokinetic and pharmacodynamic properties of metoprolol in patients with impaired renal functionQ72421111
Variability of beta-blocker pharmacokinetics in young volunteersQ72536838
P433issue4
P304page(s)355-361
P577publication date1987-01-01
P1433published inEuropean Journal of Clinical PharmacologyQ1376707
P1476titleInfluence of smoking and gender on the disposition kinetics of metoprolol
P478volume33

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cites work (P2860)
Q88388194A Refined Developability Classification System
Q38559763Examining the Use of a Mechanistic Model to Generate an In Vivo/In Vitro Correlation: Journey Through a Thought Process
Q36857756Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data

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