Orientation of epitopes influences the immunogenicity of synthetic peptide dimers

scientific article published on 01 December 1988

Orientation of epitopes influences the immunogenicity of synthetic peptide dimers is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/EJI.1830181222
P698PubMed publication ID2464496

P50authorJosephine H CoxQ64869594
P2093author name stringFrancis MJ
Lamb JR
Young DB
Ivanyi J
Syred AD
P2860cites workGeneral method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acidsQ24612820
Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteinsQ27860987
Function of macrophages in antigen recognition by guinea pig T lymphocytes. I. Requirement for histocompatible macrophages and lymphocytesQ36272607
Protective immunogenicity and T lymphocyte specificity of a trivalent hybrid peptide containing NH2-terminal sequences of types 5, 6, and 24 M proteins synthesized in tandemQ36353910
Influences of antigen processing on the expression of the T cell repertoire. Evidence for MHC-specific hindering structures on the products of processingQ36355124
Efficient mapping of protein antigenic determinantsQ37399826
A recombinant 64 kilodalton protein of Mycobacterium bovis bacillus Calmette-Guerin specifically stimulates human T4 clones reactive to mycobacterial antigensQ41815508
The functional dissection of an antigen molecule: specificity of humoral and cellular immune responses to glucagonQ42002697
Antibody response in pig nasal fluid and serum following foot-and-mouth disease infection or vaccinationQ42110704
Enumeration of T cells reactive with Mycobacterium tuberculosis organisms and specific for the recombinant mycobacterial 64-kDa proteinQ44601613
Improved immunogenicity of a peptide epitope after fusion to hepatitis B core proteinQ44806763
Immunological priming with synthetic peptides of foot-and-mouth disease virusQ45837948
Fusion proteins with multiple copies of the major antigenic determinant of foot-and-mouth disease virus protect both the natural host and laboratory animalsQ45847788
Non-responsiveness to a foot-and-mouth disease virus peptide overcome by addition of foreign helper T-cell determinantsQ45847888
Antibody production to the nucleocapsid and envelope of the hepatitis B virus primed by a single synthetic T cell siteQ45847909
Construction of synthetic immunogen: use of new T-helper epitope on malaria circumsporozoite proteinQ47645821
The carrier effect in the secondary response to hapten-protein conjugates. II. Cellular cooperation.Q51023960
Regulation of antibody isotype secretion by subsets of antigen-specific helper T cells.Q51186886
Protection of cattle against foot-and-mouth disease by a synthetic peptide.Q53889573
Solid Phase Peptide Synthesis. I. The Synthesis of a TetrapeptideQ55869789
Protection against foot-and-mouth disease by immunization with a chemically synthesized peptide predicted from the viral nucleotide sequenceQ59068267
Binding of immunogenic peptides to Ia histocompatibility moleculesQ59070314
A synthetic vaccine constructed by copolymerization of B and T cell determinantsQ68988248
Engineering of immunogenic peptides by co-linear synthesis of determinants recognized by B and T cellsQ69002035
Enhancement of peptide immunogenicity by linear polymerizationQ69021622
P433issue12
P304page(s)2015-2019
P577publication date1988-12-01
P1433published inEuropean Journal of ImmunologyQ5412727
P1476titleOrientation of epitopes influences the immunogenicity of synthetic peptide dimers
P478volume18

Reverse relations

cites work (P2860)
Q39878888A large-scale evaluation of peptide vaccines against foot-and-mouth disease: lack of solid protection in cattle and isolation of escape mutants
Q28379265A strategy for rational design of fully synthetic glycopeptide conjugate vaccines
Q27486187A synthetic peptide to the E glycoprotein of Murray Valley encephalitis virus defines multiple virus-reactive T- and B-cell epitopes
Q67666655Antibodies raised against peptide fragments of bovine αs1-casein cross-react with the intact protein only when the peptides contain both B and T cell determinants
Q44089468Antibodies raised against peptide fragments of bovine αs1-casein cross-react with the native protein, but recognize sites distinct from the determinants on the protein
Q39340719Antibody responses to non-immunogenic synthetic peptides induced by co-immunization with immunogenic peptides
Q72070596Characterization of T-cell responses to the house dust mite allergen Der p II in mice. Evidence for major and cryptic epitopes
Q40308695Cross-reactive and serotype-specific antibodies against foot-and-mouth disease virus generated by different regions of the same synthetic peptide
Q34633581Delineation of the minimal hepatitis B surface antigen-specific B- and T-cell epitope contained within an anti-idiotype-derived pentadecapeptide
Q78066624Design of highly immunogenic liposomal constructs combining structurally independent B cell and T helper cell peptide epitopes
Q62657294Differences in secondary structure of HAV-synthetic peptides induced by the sequential order of T- and B-cell epitopes
Q69090096Differential pattern of T cell recognition of the 65-kDa mycobacterial antigen following immunization with the whole protein or peptides
Q67667689Enhanced immunogenicity of recombinant peptide fusions containing multiple copies of a heterologous T helper epitope
Q27486235Enhancement of the antibody response to flavivirus B-cell epitopes by using homologous or heterologous T-cell epitopes
Q40374626Epitope specificity and isoforms of the mycobacterial 19-kilodalton antigen
Q92051391Evaluating the immunogenicity of chemically-synthesised peptides derived from foot-and-mouth disease VP1, VP2 and VP3 proteins as vaccine candidates
Q38203257Function and Potentials of M. tuberculosis Epitopes
Q41292354H-2-associated effects of flanking residues on the recognition of a permissive mycobacterial T-cell epitope
Q36499432Heat Shock Proteins as Antigens of Bacterial and Parasitic Pathogens
Q40795523High and low responsiveness to vaccines in farm animals
Q41563249Human cartilage aggrecan CS1 region contains cryptic T-cell recognition sites
Q33565109Human cartilage proteoglycans as T cell autoantigens
Q39602247Identification of T-cell epitopes in nonstructural proteins of foot-and-mouth disease virus.
Q46017381Immunization with a synthetic robustoxin derivative lacking disulphide bridges protects against a potentially lethal challenge with funnel-web spider (Atrax robustus) venom.
Q54375647Immunogenic comparison for two different recombinant chimeric peptides (CP12 and CP22) containing one or two copies of three linear B cell epitopes from β-hCG subunit
Q43565868Impact of epitope permutations in the antibody response of mice to a multi-epitope polypeptide of the V3 loop of human immunodeficiency virus type 1.
Q67691162Induction of antibodies against a peptide hapten does not require covalent linkage between the hapten and a class II presentable T helper peptide
Q72091601Induction of antibody responses to breast carcinoma associated mucins using synthetic peptide constructs as immunogens
Q39710931Induction of virus-specific neutralizing immune response against West Nile and Japanese encephalitis viruses by chimeric peptides representing T-helper and B-cell epitopes
Q40047371Influence of epitope polarity and adjuvants on the immunogenicity and efficacy of a synthetic peptide vaccine against Semliki Forest virus
Q45873996Molecular cloning and expression of the VP1 gene of foot-and-mouth disease virus C1 in E. coli: effect on bacterial cell viability
Q40640674Need for cellular and humoral immune responses in bovines to ensure protection from foot-and-mouth disease virus (FMDV)--a point of view
Q45851828Neutralizing antibodies to all seven serotypes of foot-and-mouth disease virus elicited by synthetic peptides
Q73428233On the immunogenic properties of retro-inverso peptides. Total retro-inversion of T-cell epitopes causes a loss of binding to MHC II molecules
Q52065347Peptide‐induced memory (IgG) response, cross‐reactive with native proteins, requires covalent linkage of a specific B cell epitope with a T cell epitope
Q44693960Polarity of immunogens: implications for vaccine design
Q71617364Preferential pairing of T and B cells for production of antibodies without covalent association of T and B epitopes
Q45874977Proliferative lymphocyte responses to foot-and-mouth disease virus and three FMDV peptides after vaccination or immunization with these peptides in cattle
Q51837773Rapid Monoclonal Antibody Generation Via Dendritic Cell TargetingIn Vivo
Q44433947Recombinant fusion peptides containing single or multiple repeats of a ubiquitous T-helper epitope are highly immunogenic
Q62727136Simple strategy to induce antibodies of distinct specificity: Application to the mapping of gp120 and inhibition of HIV-1 infectivity
Q74497671Specificity of the T-cell responses in covalently linked peptides each comprising of a T helper epitope
Q27486548T-helper cell and associated antibody response to synthetic peptides of the E glycoprotein of Murray Valley encephalitis virus
Q39340678The influence of orientation and number of copies of T and B cell epitopes on the specificity and affinity of antibodies induced by chimeric peptides
Q74261407The specificity of antibodies raised against a T cell peptide is influenced by peptide amidation
Q67657519Treatment of adjuvant arthritis in rats: Vaccination potential of a synthetic nonapeptide from the 65 kDa heat shock protein of mycobacteria

Search more.