Somatic mutations at a heterozygous autosomal locus in human cells occur more frequently by allele loss than by intragenic structural alterations

scientific article published on 01 May 1986

Somatic mutations at a heterozygous autosomal locus in human cells occur more frequently by allele loss than by intragenic structural alterations is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/BF01570784
P698PubMed publication ID3012798

P2093author name stringDryja TP
Little JB
Yandell DW
P433issue3
P921main subjectheterozygosityQ124059385
P304page(s)255-263
P577publication date1986-05-01
P1433published inSomatic Cell and Molecular GeneticsQ7559232
P1476titleSomatic mutations at a heterozygous autosomal locus in human cells occur more frequently by allele loss than by intragenic structural alterations
P478volume12

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cites work (P2860)
Q41694387A comparison of induced mutation at homologous alleles of the tk locus in human cells
Q30530987A system for assaying homologous recombination at the endogenous human thymidine kinase gene
Q54396719Adenosine kinase deficiency in tritiated deoxyadenosine-resistant mouse S49 lymphoma cell lines.
Q37480732Base substitutions, frameshifts, and small deletions constitute ionizing radiation-induced point mutations in mammalian cells
Q36563592Clonal analysis of delayed karyotypic abnormalities and gene mutations in radiation-induced genetic instability
Q69749274Cytogenetic analysis of spontaneous and 2-cyanoethylene oxide-induced tk-/- mutants in TK6 human lymphoblastoid cultures
Q41121273Cytotoxic and mutagenic responses to X-rays and chemical mutagens in normal and p53-mutated human lymphoblastoid cells
Q41525588DNA-sequence specificity of mutations at the human thymidine kinase locus
Q34323263Deletion of stably integrated DNA is suppressed by cadmium and zinc
Q41686662Dependence of the Mutation Spectrum in a Shuttle Plasmid Replicated in Human Lymphoblasts on Dose of Gamma Radiation
Q43955963Deregulated DNA polymerase beta strengthens ionizing radiation-induced nucleotidic and chromosomal instabilities
Q41243857Development of a novel mouse tk+/- embryonic stem cell line for use in mutagenicity studies
Q42167788Different capacities for recombination in closely related human lymphoblastoid cell lines with different mutational responses to X-irradiation
Q41564882Different cytotoxic and mutagenic responses induced by X-rays in two human lymphoblastoid cell lines derived from a single donor
Q36656161Elevated frequency of microsatellite mutations in TK6 human lymphoblast clones selected for mutations at the thymidine kinase locus
Q72703033Epigenetic lesions at the H19 locus in Wilms' tumour patients
Q42053098Estimation of mutation rates based on the analysis of polypeptide constituents of cultured human lymphoblastoid cells
Q41703094Evaluation of the genotoxic potential of glutaraldehyde
Q41525579Evidence for high-frequency allele loss at the aprt locus in TK6 human lymphoblasts
Q34381440Frequencies of independent and simultaneous selection of Chinese hamster cells for methotrexate and doxorubicin (adriamycin) resistance
Q40829083Frequency of CD59 mutations induced in human-hamster hybrid A(L) cells by low-dose X-irradiation
Q35197581Gene inactivation as a mechanism for the expression of recessive phenotypes
Q34303544Heavy ion mutagenesis: Linear energy transfer effects and genetic linkage
Q73271482Hprt- mutation spectrum in a closely related pair of human bladder tumour cell lines after gamma-irradiation at different dose-rates
Q33786384Identification of the albino mutation of mouse tyrosinase by analysis of an in vitro revertant
Q35032665In vitro models of carcinogenesis: expression of recessive genes by chromosomal mutations
Q41525555Insertioanl inactivation of the tk locus in a human B lymphoblastoid cell line by a retroviral shuttle vector
Q71120859Inverse dose-rate effect for mutation induction by gamma-rays in human lymphoblasts
Q33703747Ionizing radiation and genetic risks. X. The potential "disease phenotypes" of radiation-induced genetic damage in humans: perspectives from human molecular biology and radiation genetics
Q39633008Ionizing radiation-induced mutagenesis
Q33771567Ionizing radiation-induced mutagenesis: radiation studies in Neurospora predictive for results in mammalian cells
Q34134350Loss of heterozygosity in somatic cells of the mouse. An important step in cancer initiation?
Q40719018Molecular analysis of mutations at the HPRT and TK loci of human lymphoblastoid cells after combined treatments with 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosinedagger
Q72104238Molecular analysis of mutations at the tk locus of L5178Y mouse-lymphoma cells induced by ethyl methanesulphonate and mitomycin C
Q37656548Molecular dissection of mutations at the heterozygous thymidine kinase locus in mouse lymphoma cells
Q44060415Mutant frequency and mutational spectra in the Tk and Hprt genes of N-ethyl-N-nitrosourea-treated mouse lymphoma cellsdagger
Q72078171Mutational specificity of oxidative DNA damage
Q40505031RFLP mapping of thymidine kinase mutants places Dl7S4 proximal to the human TK1 locus
Q36290851Radiation and cancer: a two-edged sword
Q40875928Radiation specific patterns of loss of heterozygosity on chromosome 17q.
Q41667952Reduction to homozygosity is the predominant spontaneous mutational event in cultured human lymphoblastoid cells
Q35245482Search for mutations altering protein charge and/or function in children of atomic bomb survivors: final report
Q41552163Selection for spontaneous null mutations in a chromosomally-integrated HSV-1 thymidine kinase gene yields deletions and a mutation caused by intragenic illegitimate recombination
Q41750025Sodium fluoride is a less efficient human cell mutagen at low concentrations
Q33574499Spectrum of spontaneous mutation at the APRT locus of Chinese hamster ovary cells: an analysis at the DNA sequence level
Q41330895Spontaneous and ionizing radiation induced mutations involve large events when selecting for loss of an autosomal locus
Q40971333Tk+/- mouse model for detecting in vivo mutation in an endogenous, autosomal gene
Q36817436X rays induce interallelic homologous recombination at the human thymidine kinase gene
Q40798780X-ray induction of microsatellite instability at autosomal loci in human lymphoblastoid WTK1 cells

Q54972535TK6described by sourceP1343

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