Microglial cells and amyloid beta protein (A beta) deposition; association with A beta 40-containing plaques

scientific article published on 01 January 1995

Microglial cells and amyloid beta protein (A beta) deposition; association with A beta 40-containing plaques is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/BF00294808
P698PubMed publication ID8560980

P2093author name stringN Suzuki
Y Ihara
D M Mann
T Iwatsubo
H Fukumoto
A Odaka
P2860cites workDominant and differential deposition of distinct beta-amyloid peptide species, A beta N3(pE), in senile plaques.Q53203663
The lack of accumulation of senile plaques or amyloid burden in Alzheimer's disease suggests a dynamic balance between amyloid deposition and resolution.Q53207598
Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretionQ67766420
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Amyloid beta protein (A beta) deposition: A beta 42(43) precedes A beta 40 in Down syndromeQ72107326
Polyclonals to beta-amyloid(1-42) identify most plaque and vascular deposits in Alzheimer cortex, but not striatumQ72641621
An important role of heparan sulfate proteoglycan (Perlecan) in a model system for the deposition and persistence of fibrillar A beta-amyloid in rat brainQ28258921
The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's diseaseQ28610089
Early accumulation of heparan sulfate in neurons and in the beta-amyloid protein-containing lesions of Alzheimer's disease and Down's syndromeQ35811925
The presence of heparan sulfate proteoglycans in the neuritic plaques and congophilic angiopathy in Alzheimer's diseaseQ35819186
Heparan sulfate proteoglycan in diffuse plaques of hippocampus but not of cerebellum in Alzheimer's disease brainQ35833402
Development of a monoclonal antibody specific for the COOH-terminal of beta-amyloid 1-42 and its immunohistochemical reactivity in Alzheimer's disease and related disordersQ35833877
Mucopolysaccharides synthesized by cultured glial cells derived from a patient with Sanfilippo A syndromeQ39739030
Normal and abnormal biology of the beta-amyloid precursor proteinQ40766055
Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's diseaseQ40870408
Acute phase proteins but not activated microglial cells are present in parenchymal beta/A4 deposits in the brains of patients with hereditary cerebral hemorrhage with amyloidosis-Dutch typeQ41764414
Neuronal and microglial involvement in beta-amyloid protein deposition in Alzheimer's diseaseQ42094459
In-vitro matured human macrophages express Alzheimer's beta A4-amyloid precursor protein indicating synthesis in microglial cellsQ43466393
Inability to detect beta-amyloid protein precursor mRNA in Alzheimer plaque-associated microgliaQ44304076
beta-Amyloid peptide produced in vitro is degraded by proteinases released by cultured cellsQ46631570
Morphologic association between microglia and senile plaque amyloid in Alzheimer's diseaseQ46691404
Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).Q48092766
The complex of microglial cells and amyloid star in three-dimensional reconstruction.Q52243683
Ferritin is a component of the neuritic (senile) plaque in Alzheimer dementia.Q52243684
Increased senile plaques without microglia in Alzheimer's disease.Q53184055
Ultrastructural studies of the cells forming amyloid fibers in classical plaques.Q53187413
Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease.Q53189340
Microglia in Diffuse Plaques in Hereditary Cerebral Hemorrhage with Amyloidosis (Dutch). An Immunohistochemical StudyQ53199859
P433issue5
P921main subjectmicrogliaQ1622829
P304page(s)472-477
P577publication date1995-01-01
P1433published inActa NeuropathologicaQ343168
P1476titleMicroglial cells and amyloid beta protein (A beta) deposition; association with A beta 40-containing plaques
P478volume90

Reverse relations

cites work (P2860)
Q48179910A central role for astrocytes in the inflammatory response to beta-amyloid; chemokines, cytokines and reactive oxygen species are produced
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