Loss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis

scientific article published on 01 January 1996

Loss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/NM0196-72
P698PubMed publication ID8564846

P50authorDenise GallowayQ91250425
P2093author name stringF Y Lee
A F Wahl
K L Donaldson
S A Foster
C Fairchild
G W Demers
P2860cites workWAF1, a potential mediator of p53 tumor suppressionQ27861121
Identification of p53 as a sequence-specific DNA-binding proteinQ28282745
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumoursQ29547697
The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53Q29547773
p53-dependent apoptosis modulates the cytotoxicity of anticancer agentsQ29615031
p53 is required for radiation-induced apoptosis in mouse thymocytesQ29620281
Phase II study of paclitaxel in patients with extensive-disease small-cell lung cancer: an Eastern Cooperative Oncology Group studyQ33489695
Human placental cells transformed by tsA mutants of simian virus 40: a model system for the study of placental functionsQ33968570
Monoclonal antibodies specific for simian virus 40 tumor antigensQ34249232
Growth arrest by induction of p53 in DNA damaged keratinocytes is bypassed by human papillomavirus 16 E7.Q35230883
Mechanism of action of taxolQ35255662
Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cellsQ35476763
Taxol stabilizes microtubules in mouse fibroblast cellsQ36360499
p53 mutations increase resistance to ionizing radiationQ36373753
Induction of cellular p53 activity by DNA-damaging agents and growth arrest.Q36690595
Three-hour paclitaxel infusion in patients with refractory and relapsed non-Hodgkin's lymphomaQ40687772
Increased accumulation of p53 protein in cisplatin-resistant ovarian cell linesQ41520126
Association of human papillomavirus types 16 and 18 E6 proteins with p53.Q43701619
MAP kinase becomes stably activated at metaphase and is associated with microtubule-organizing centers during meiotic maturation of mouse oocytes.Q49137334
Differential disruption of genomic integrity and cell cycle regulation in normal human fibroblasts by the HPV oncoproteins.Q52512094
Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53.Q53505779
Cytotoxicity of the anticancer agents cisplatin and taxol during cell proliferation and the cell cycle.Q54201959
Thymocyte apoptosis induced by p53-dependent and independent pathways.Q54242475
A p53-dependent mouse spindle checkpointQ56445949
A deadly inheritanceQ59053969
Shared actions of endotoxin and taxol on TNF receptors and TNF releaseQ68086156
Nonlinear pharmacokinetics and metabolism of paclitaxel and its pharmacokinetic/pharmacodynamic relationships in humansQ72354126
Microtubule stabilization by taxol inhibits initiation of DNA synthesis by thrombin and by epidermal growth factorQ72521166
European-Canadian randomized trial of paclitaxel in relapsed ovarian cancer: high-dose versus low-dose and long versus short infusionQ72880127
P433issue1
P921main subjectpaclitaxelQ423762
apoptotic processQ14599311
P304page(s)72-79
P577publication date1996-01-01
P1433published inNature MedicineQ1633234
P1476titleLoss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis
P478volume2

Reverse relations

cites work (P2860)
Q924815316-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase-2 Regulates TP53-Dependent Paclitaxel Sensitivity in Ovarian and Breast Cancers
Q44141797A Phase I/II trial of concurrent docetaxel and radiation after induction chemotherapy in patients with poor prognosis squamous cell carcinoma of the head and neck
Q44759597A Pilot Study of Chemoradiotherapy With Weekly Docetaxel for Thoracic Esophageal Carcinoma With T4 and/or M1 Lymph Node Metastasis
Q37589239A model of sensitivity and resistance to histone deacetylase inhibitors in diffuse large B cell lymphoma: Role of cyclin-dependent kinase inhibitors
Q33516915A new isoquinolinium derivative, Cadein1, preferentially induces apoptosis in p53-defective cancer cells with functional mismatch repair via a p38-dependent pathway
Q40640289A novel c-kit positive biphenotypic acute leukemia cell line, TMBL-1, carrying a p53 point mutation
Q34552027A novel pentamethoxyflavone down-regulates tumor cell survival and proliferative and angiogenic gene products through inhibition of IκB kinase activation and sensitizes tumor cells to apoptosis by cytokines and chemotherapeutic agents.
Q36294890A phase II study of paclitaxel in heavily pretreated patients with small-cell lung cancer
Q36696776A phase II study of sequential carboplatin, paclitaxel and topotecan in patients with previously untreated advanced ovarian cancer
Q36737086A prospective phase II study of chemoradiation followed by adjuvant chemotherapy for FIGO stage I-IIIA (1988) uterine papillary serous carcinoma of the endometrium.
Q40807758A role for loss of p53 function in sensitivity of ovarian carcinoma cells to taxanes
Q41126929Acquisition of taxol resistance via P-glycoprotein- and non-P-glycoprotein-mediated mechanisms in human ovarian carcinoma cells
Q36177359Activation of Cdc2 contributes to apoptosis in HPV E6 expressing human keratinocytes in response to therapeutic agents
Q80830503Alternol inhibits proliferation and induces apoptosis in mouse lymphocyte leukemia (L1210) cells
Q33800817An image-based, high-throughput screening assay for molecules that induce excess DNA replication in human cancer cells
Q77227817An initial experience using concurrent paclitaxel and radiation in the treatment of head and neck malignancies
Q33654566An update on radiation therapy in breast cancer
Q36623220Anti-Her-2/neu antibody induces apoptosis in Her-2/neu overexpressing breast cancer cells independently from p53 status
Q41076902Anti-apoptotic activity of low levels of wild-type p53.
Q55091443Anti-tumor efficacy of paclitaxel against human lung cancer xenografts.
Q36085436Antitumor evaluation of two selected Pakistani plant extracts on human bone and breast cancer cell lines
Q73468224Apoptosis and cutaneous biology
Q41737530Apoptosis by p53: mechanisms, regulation, and clinical implications
Q40458245Apoptosis of non-small-cell lung cancer cell lines after paclitaxel treatment involves the BH3-only proapoptotic protein Bim.
Q36323387Arrest of mammalian fibroblasts in G1 in response to actin inhibition is dependent on retinoblastoma pocket proteins but not on p53
Q41824137Association between mitotic spindle checkpoint impairment and susceptibility to the induction of apoptosis by anti-microtubule agents in human lung cancers
Q74245221Association of p53 gene mutations with sensitivity to TZT-1027 in patients with clinical lung and renal carcinoma
Q57463137BGJ398, A Pan-FGFR Inhibitor, Overcomes Paclitaxel Resistance in Urothelial Carcinoma with FGFR1 Overexpression
Q81608794Beta-tubulin isotype classes II and V expression patterns in nonsmall cell lung carcinomas
Q40665228Biological basis for chemo-radiotherapy interactions
Q35567256Blocking anaplerotic entry of glutamine into the TCA cycle sensitizes K-Ras mutant cancer cells to cytotoxic drugs
Q33916340Carcinogenic effects of ptaquiloside in bracken fern and related compounds
Q40782148Cell cycle checkpoint efficiency and cellular response to paclitaxel in prostate cancer cells
Q44691785Cell status--dead or alive?
Q42829823Centrosome and spindle pole microtubules are main targets of a fluorescent taxoid inducing cell death.
Q35974979Centrosome hypertrophy in human breast tumors: implications for genomic stability and cell polarity
Q73574213Chemotherapy for recurrent ovarian cancer
Q40901484Cisplatin-resistant HeLa cells are resistant to apoptosis via p53-dependent and -independent pathways
Q28363906Cisplatinum and taxol induce different patterns of p53 phosphorylation
Q35127312Clinical Implication of p53 Mutation in Lung Cancer
Q24806527Clinical trials update of the European Organization for Research and Treatment of Cancer Breast Cancer Group
Q73594102Colony formation of soft tissue sarcoma cells is inhibited by lipid-mediated antisense oligodeoxynucleotides targeting the human mdm2 oncogene
Q34785152Concurrent administration of Docetaxel and Stealth liposomal doxorubicin with radiotherapy in non-small cell lung cancer : excellent tolerance using subcutaneous amifostine for cytoprotection
Q48283141Concurrent twice-a-week docetaxel and radiotherapy: a dose escalation trial with immunological toxicity evaluation
Q40574551Cross-resistance studies of isogenic drug-resistant breast tumor cell lines support recent clinical evidence suggesting that sensitivity to paclitaxel may be strongly compromised by prior doxorubicin exposure
Q33249461Cyclo-oxygenase-2 (Cox-2) expression and resistance to platinum versus platinum/paclitaxel containing chemotherapy in advanced ovarian cancer.
Q73905123Cytotoxic effects of topotecan combined with various active G2/M-phase anticancer drugs in human tumor-derived cell lines
Q37089273DNA damage and p53-mediated cell cycle arrest: a reevaluation.
Q38309088Delayed expression of apoptosis in human lymphoma cells undergoing low-dose taxol-induced mitotic stress.
Q36294984Detection of TP53 mutation, loss of heterozygosity and DNA content in fine-needle aspirates of breast carcinoma
Q24682740Dido disruption leads to centrosome amplification and mitotic checkpoint defects compromising chromosome stability
Q41155486Differential Taxol-dependent arrest of transformed and nontransformed cells in the G1 phase of the cell cycle, and specific-related mortality of transformed cells
Q79366828Distinct subtypes of serous ovarian carcinoma identified by p53 determination
Q48541625Disulfide-masked iron prochelators: Effects on cell death, proliferation, and hemoglobin production
Q41541911Docetaxel, Cisplatin, and 5-fluorouracil (DCF) chemotherapy in the treatment of metastatic or unresectable locally recurrent anal squamous cell carcinoma: a phase II study of French interdisciplinary GERCOR and FFCD groups (Epitopes-HPV02 study).
Q90450359Docetaxel, cisplatin, and fluorouracil chemotherapy for metastatic or unresectable locally recurrent anal squamous cell carcinoma (Epitopes-HPV02): a multicentre, single-arm, phase 2 study
Q36809577Downregulation of miRNA-31 induces taxane resistance in ovarian cancer cells through increase of receptor tyrosine kinase MET.
Q34785151Driving p53 response to Bax activation greatly enhances sensitivity to taxol by inducing massive apoptosis.
Q30438642Drug resistance associated with loss of p53 involves extensive alterations in microtubule composition and dynamics.
Q39777499Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53.
Q51836563Effect of microcystin-LR and cyanobacterial extract from Polish reservoir of drinking water on cell cycle progression, mitotic spindle, and apoptosis in CHO-K1 cells.
Q42548550Effect of radiation and paclitaxel on p53 expression in murine tumors sensitive or resistant to apoptosis induction
Q40679747Effect of trans-resveratrol on signal transduction pathways involved in paclitaxel-induced apoptosis in human neuroblastoma SH-SY5Y cells
Q35971203Evaluation of activity and combination strategies with the microtubule-targeting drug sagopilone in breast cancer cell lines.
Q36530680Expression of RET finger protein predicts chemoresistance in epithelial ovarian cancer
Q36612301Factors influencing p53 expression in ovarian cancer as a biomarker of clinical outcome in multicentre studies
Q43218675First-line chemotherapy for ovarian cancer - the controversy continues
Q34462139Future directions for the management of ovarian cancer
Q39788259Garlic constituent diallyl trisulfide induced apoptosis in MCF7 human breast cancer cells
Q28542669Gene expression profiling reveals epithelial mesenchymal transition (EMT) genes can selectively differentiate eribulin sensitive breast cancer cells
Q34813092Genetic alterations in ovarian cancer cells that might account for sensitivity to chemotherapy in patients.
Q73540284Genetic determinants of response to chemotherapy in transgenic mouse mammary and salivary tumors
Q58766772Genetics and Expression Profile of the Tubulin Gene Superfamily in Breast Cancer Subtypes and Its Relation to Taxane Resistance
Q35726998Genotype and Haplotype Analyses of TP53 Gene in Breast Cancer Patients: Association with Risk and Clinical Outcomes
Q48116981High-level expression of ARID1A predicts a favourable outcome in triple-negative breast cancer patients receiving paclitaxel-based chemotherapy.
Q34162123Human parvovirus B19 causes cell cycle arrest of human erythroid progenitors via deregulation of the E2F family of transcription factors
Q73574759Hyperproliferation and p53 status of lens epithelial cells derived from alphaB-crystallin knockout mice
Q73263605IC261, a specific inhibitor of the protein kinases casein kinase 1-delta and -epsilon, triggers the mitotic checkpoint and induces p53-dependent postmitotic effects
Q47772595Implications of p53 alterations and anti-p53 antibody response in head and neck squamous cell carcinomas
Q34727266Importance of detecting numerical versus structural chromosome aberrations
Q47157561In-Tether Chiral Center Induced Helical Peptide Modulators Target p53-MDM2/MDMX and Inhibit Tumor Growth in Stem-Like Cancer Cell
Q28352698Inactivation of wild-type p53 by a dominant negative mutant renders MCF-7 cells resistant to tubulin-binding agent cytotoxicity
Q28539684Increased growth-inhibitory and cytotoxic activity of arsenic trioxide in head and neck carcinoma cells with functional p53 deficiency and resistance to EGFR blockade
Q36292481Induction of apoptosis by taxol and cisplatin and effect on cell cycle-related proteins in cisplatin-sensitive and -resistant human ovarian cells
Q35797390Induction of apoptosis in human papillomaviruspositive cancer cells by peptide aptamers targeting the viral E6 oncoprotein
Q31137239Induction of lysosomal membrane permeabilization by compounds that activate p53-independent apoptosis
Q36114881Induction of p53-dependent and p53-independent cellular responses by topoisomerase 1 inhibitors
Q30783266Influence of p53 and bcl-2 on chemosensitivity in benign and malignant prostatic cell lines
Q74288176Is p53 a protein that predicts the response to chemotherapy in node negative breast cancer?
Q43901360Low HER2/neu gene expression is associated with pathological response to concurrent paclitaxel and radiation therapy in locally advanced breast cancer
Q40794489Low concentrations of paclitaxel induce cell type-dependent p53, p21 and G1/G2 arrest instead of mitotic arrest: molecular determinants of paclitaxel-induced cytotoxicity
Q38882347Low inducible expression of p21Cip1 confers resistance to paclitaxel in BRAF mutant melanoma cells with acquired resistance to BRAF inhibitor
Q73093705MEK inhibition enhances paclitaxel-induced tumor apoptosis
Q36201008Mammary Stem Cells and Tumor-Initiating Cells Are More Resistant to Apoptosis and Exhibit Increased DNA Repair Activity in Response to DNA Damage
Q77994535Methyl methanesulfonate and hydrogen peroxide differentially regulate p53 accumulation in hepatoblastoma cells
Q27690249Microtubule-binding agents: a dynamic field of cancer therapeutics
Q34285363Mifepristone prevents repopulation of ovarian cancer cells escaping cisplatin-paclitaxel therapy.
Q35645461Mitogenic action of the androgen receptor sensitizes prostate cancer cells to taxane-based cytotoxic insult
Q35633680Molecular subtypes of breast cancer in relation to paclitaxel response and outcomes in women with metastatic disease: results from CALGB 9342
Q33186850Mutation of p53 and consecutive selective drug resistance in B-CLL occurs as a consequence of prior DNA-damaging chemotherapy
Q41931874Mutation of the p53 gene in human astrocytic tumours correlates with increased resistance to DNA-damaging agents but not to anti-microtubule anti-cancer agents
Q33618285Mutational studies on single circulating tumor cells isolated from the blood of inflammatory breast cancer patients
Q40711094Mutations of TP53 do not correlate with the sensitivity to paclitaxel--a study using 27 gynaecological cancer cell lines.
Q64083387NUP98 - a novel predictor of response to anthracycline-based chemotherapy in triple negative breast cancer
Q42804466Nicotinamide- and caspase-mediated inhibition of poly(ADP-ribose) polymerase are associated with p53-independent cell cycle (G2) arrest and apoptosis
Q40343222Novel high-affinity PPARgamma agonist alone and in combination with paclitaxel inhibits human anaplastic thyroid carcinoma tumor growth via p21WAF1/CIP1.
Q38407182Nuclear survivin expression is a positive prognostic factor in taxane-platinum-treated ovarian cancer patients
Q36254803Nucleotide excision repair and anti-cancer chemotherapy
Q42818247Ovarian cancer cisplatin-resistant cell lines: multiple changes including collateral sensitivity to Taxol.
Q35166813Ovarian cancer: strategies for overcoming resistance to chemotherapy
Q28613291Overexpression of ErbB2 blocks Taxol-induced apoptosis by upregulation of p21Cip1, which inhibits p34Cdc2 kinase
Q39604427Overexpression of simian virus 40 small-T antigen blocks centrosome function and mitotic progression in human fibroblasts
Q55111247P-glycoprotein is positively correlated with p53 protein accumulation in human colorectal cancers.
Q33913135P53 in human melanoma fails to regulate target genes associated with apoptosis and the cell cycle and may contribute to proliferation
Q41129549P53 protein expression in human multidrug-resistant CEM lymphoblasts
Q34539978P53: an ubiquitous target of anticancer drugs
Q40775266Paclitaxel and concurrent radiation for gastric cancer
Q35634812Paclitaxel and concurrent radiation in upper gastrointestinal cancers
Q40749281Paclitaxel combined with fractionated radiation in vitro: a study with vulvar squamous cell carcinoma cell lines
Q52826331Paclitaxel selects for mutant or pseudo-null p53 in drug resistance associated with tubulin mutations in human cancer.
Q40939584Paclitaxel sensitivity correlates with p53 status and DNA fragmentation, but not G2/M accumulation
Q35852309Pathways of apoptotic and non-apoptotic death in tumour cells
Q35121876Persistent mitochondrial hyperfusion promotes G2/M accumulation and caspase-dependent cell death
Q73934711Phase I/II dose escalation study of docetaxel and carboplatin combination supported with amifostine and GM-CSF in patients with incomplete response following docetaxel chemo-radiotherapy: additional chemotherapy enhances regression of residual cance
Q41726923Phase I/II study of paclitaxel, carboplatin, and methotrexate in advanced transitional cell carcinoma: a well-tolerated regimen with activity independent of p53 mutation
Q54111946Platinum-DNA adduct, nucleotide excision repair and platinum based anti-cancer chemotherapy.
Q40920736Poor prognosis Ewing's sarcoma and peripheral primitive neuroectodermal tumours (PNET).
Q36673922Potent inhibition of tumor survival in vivo by beta-lapachone plus taxol: combining drugs imposes different artificial checkpoints
Q33893910Predictive and prognostic impact of TP53 mutations and MDM2 promoter genotype in primary breast cancer patients treated with epirubicin or paclitaxel
Q24801874Predictive factor for the response to adjuvant therapy with emphasis in breast cancer
Q40765650Prevalent loss of mitotic spindle checkpoint in adult T-cell leukemia confers resistance to microtubule inhibitors
Q36245341Prognostic and predictive value of TP53 mutations in node-positive breast cancer patients treated with anthracycline- or anthracycline/taxane-based adjuvant therapy: results from the BIG 02-98 phase III trial
Q36421995Proliferation, migration and invasion of human glioma cells exposed to paclitaxel (Taxol) in vitro
Q35889568Protein expression, survival and docetaxel benefit in node-positive breast cancer treated with adjuvant chemotherapy in the FNCLCC-PACS 01 randomized trial
Q34001266Purine Nucleoside Phosphorylase mediated molecular chemotherapy and conventional chemotherapy: a tangible union against chemoresistant cancer
Q57011065Radiation-induced gadd45 expression correlates with clinical response to radiotherapy of cervical carcinoma
Q37208757Recent advances in systemic therapy: new diagnostics and biological predictors of outcome in early breast cancer.
Q34605615Regulation of apoptosis by the papillomavirus E6 oncogene
Q39583941Regulation of proliferation-survival decisions during tumor cell hypoxia
Q31655353Repression of human reduced folate carrier gene expression by wild type p53.
Q41735655Role of apoptotic response in cellular resistance to cytotoxic agents
Q73164603Role of p53 in drug resistance in ovarian cancer
Q37630572Role of prolonged mitotic checkpoint activation in the formation and treatment of cancer
Q36613525SCOTROC 2B: feasibility of carboplatin followed by docetaxel or docetaxel-irinotecan as first-line therapy for ovarian cancer
Q38262971SP600125 has a remarkable anticancer potential against undifferentiated thyroid cancer through selective action on ROCK and p53 pathways.
Q40956127SV40 virus transformation down-regulates endothelin receptor
Q39562856Selective cytotoxicity of goniothalamin against hepatoblastoma HepG2 cells.
Q43690855Selective tumor sensitization to taxanes with the mAb-drug conjugate cBR96-doxorubicin
Q74273660Sensitivity to paclitaxel is not related to p53-dependent apoptosis in ovarian cancer cells
Q44098571Sequential combination chemotherapy in patients with advanced nonsmall cell lung carcinoma. Carboplatin and gemcitabine followed by paclitaxel
Q33369125Sequential gemcitabine-carboplatin followed by paclitaxel-carboplatin in the first-line treatment of advanced ovarian cancer: A phase II study
Q24679386Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (taxol)-exposed cells
Q101133368Single-cell analysis of AIMP2 splice variants informs on drug sensitivity and prognosis in hematologic cancer
Q33898768Soft tissue sarcomas and p53 mutations
Q35080295Study of suboptimum treatment response: lessons from breast cancer
Q44943097Subadditive interaction of radiation and Taxol in vitro
Q38402017Sulforaphane sensitizes human breast cancer cells to paclitaxel-induced apoptosis by downregulating the NF-κB signaling pathway
Q36294095Suppression of p53 function in normal human mammary epithelial cells increases sensitivity to extracellular matrix-induced apoptosis
Q31384854Susceptibility to drug-induced apoptosis correlates with differential modulation of Bad, Bcl-2 and Bcl-xL protein levels
Q53588202Swearing off the oath?
Q36565011Synergy between the Mos/mitogen-activated protein kinase pathway and loss of p53 function in transformation and chromosome instability
Q36108564Synergy of Taxol and radioimmunotherapy with yttrium-90-labeled chimeric L6 antibody: efficacy and toxicity in breast cancer xenografts
Q33317044TP53 status and taxane-platinum versus platinum-based therapy in ovarian cancer patients: a non-randomized retrospective study.
Q34234217TP53 status for prediction of sensitivity to taxane versus non-taxane neoadjuvant chemotherapy in breast cancer (EORTC 10994/BIG 1-00): a randomised phase 3 trial
Q22009104TRAG-3, a novel gene, isolated from a taxol-resistant ovarian carcinoma cell line
Q34348279Targeting apoptosis in prostate cancer
Q94461581Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation
Q36012041Taxane-mediated gene induction is independent of microtubule stabilization: induction of transcription regulators and enzymes that modulate inflammation and apoptosis
Q34180782Taxanes in combined modality therapy for solid tumors
Q33800977Taxanes: an overview of the pharmacokinetics and pharmacodynamics
Q40811036Taxol-induced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53.
Q43557531Taxol-induced cell cycle arrest and apoptosis: dose-response relationship in lung cancer cells of different wild-type p53 status and under isogenic condition
Q41064243Taxol-mediated augmentation of CD95 ligand-induced apoptosis of human malignant glioma cells: association with bcl-2 phosphorylation but neither activation of p53 nor G2/M cell cycle arrest
Q77753611The C-terminal domain of p53 catalyzes DNA-renaturation and strand exchange toward annealing between intact ssDNAs and toward eliminating damaged ssDNA from duplex formation through preferential recognition of damaged DNA by a duocarmycin
Q21129297The CK1 Family: Contribution to Cellular Stress Response and Its Role in Carcinogenesis
Q51497796The Presence of Serum p53 Antibody Predicts the Pathological Tumor Response to Neoadjuvant Chemotherapy with Docetaxel, Cisplatin and Fluorouracil (DCF) in Esophageal Squamous Cell Carcinoma.
Q40973393The bovine papillomavirus type 1 E6 oncoprotein sensitizes cells to tumor necrosis factor alpha-induced apoptosis
Q73062597The ins and outs of p53
Q41100367The mammalian metabolite, 2-methoxyestradiol, affects P53 levels and apoptosis induction in transformed cells but not in normal cells
Q73557025The mitotic spindle and DNA damage-induced apoptosis
Q28545041The novel tubulin polymerization inhibitor MHPT exhibits selective anti-tumor activity against rhabdomyosarcoma in vitro and in vivo
Q37356294The p53 breast cancer tissue biomarker in Indian women
Q28282671The papillomavirus E6 proteins
Q43854589The proline-rich domain of p53 is required for cooperation with anti-neoplastic agents to promote apoptosis of tumor cells
Q27686765The rebel angel: mutant p53 as the driving oncogene in breast cancer
Q36614217The role of Six1 signaling in paclitaxel-dependent apoptosis in MCF-7 cell line.
Q37895519The role of Tau protein in resistance to paclitaxel
Q41558368The transport and binding of taxol
Q38337659The viral protein Apoptin associates with the anaphase-promoting complex to induce G2/M arrest and apoptosis in the absence of p53.
Q36115202Therapy effect of either paclitaxel or cyclophosphamide combination treatment in patients with epithelial ovarian cancer and relation to TP53 gene status
Q40892936Transcriptional activation of p21WAF1 by PTEN/MMAC1 tumor suppressor
Q37180861Translation regulatory factor RBM3 is a proto-oncogene that prevents mitotic catastrophe
Q43190925Treating breast cancer before surgery
Q37602289Triple negative breast cancers: clinical and prognostic implications.
Q57140329Triple-negative breast cancer
Q34958852Txr1: a transcriptional regulator of thrombospondin-1 that modulates cellular sensitivity to taxanes
Q28652788Use of a small molecule cell cycle inhibitor to control cell growth and improve specific productivity and product quality of recombinant proteins in CHO cell cultures
Q43981311Variation in the kinetics of caspase-3 activation, Bcl-2 phosphorylation and apoptotic morphology in unselected human ovarian cancer cell lines as a response to docetaxel
Q77495165Weekly docetaxel and concomitant boost radiotherapy for non-small cell lung cancer. A phase I/II dose escalation trial
Q37225088Ziyuglycoside II inhibits the growth of human breast carcinoma MDA-MB-435 cells via cell cycle arrest and induction of apoptosis through the mitochondria dependent pathway
Q36617940c-erbB2/neu gene and chromosome 17 analysis in breast cancer by FISH on archival cytological fine-needle aspirates.
Q34192806cAC10-vcMMAE, an anti-CD30–monomethyl auristatin E conjugate with potent and selective antitumor activity
Q34489153miR-107 activates ATR/Chk1 pathway and suppress cervical cancer invasion by targeting MCL1.
Q34722558miR-34a confers chemosensitivity through modulation of MAGE-A and p53 in medulloblastoma
Q41073992p16INK4 expression is associated with the increased sensitivity of human non-small cell lung cancer cells to DNA topoisomerase I inhibitors
Q36946749p38 MAPK-induced MDM2 degradation confers paclitaxel resistance through p53-mediated regulation of EGFR in human lung cancer cells
Q58813489p53 activity and chemotherapy
Q71031884p53 and chemosensitivity
Q36644176p53 as a potential predictive factor of response to chemotherapy: feasibility of p53 assessment using a functional test in yeast from trucut biopsies in breast cancer patients
Q44417787p53 expression and resistance against paclitaxel in patients with metastatic breast cancer
Q74013106p53 immunohistochemical staining and survival after adjuvant chemotherapy for breast cancer
Q73375715p53 in drug resistance in ovarian cancer
Q40926531p53 mutations do not predict response to paclitaxel/radiation for nonsmall cell lung carcinoma
Q74650373p53 mutations predict non-small cell lung carcinoma response to radiotherapy
Q33766312p53 suppresses structural chromosome instability after mitotic arrest in human cells
Q37385633p53-Dependent and -independent responses to cisplatin in mouse testicular teratocarcinoma cells
Q28292014p53-dependent anticancer effects of leptomycin B on lung adenocarcinoma
Q36605767p53-dependent regulation of MDR1 gene expression causes selective resistance to chemotherapeutic agents
Q36573439p53-independent apoptosis induced by paclitaxel through an indirect mechanism
Q33545318p53-oriented cancer therapies: current progress
Q73549433p53-regulated GML gene expression in non-small cell lung cancer. a promising relationship to cisplatin chemosensitivity
Q36058740pH-responsive high-density lipoprotein-like nanoparticles to release paclitaxel at acidic pH in cancer chemotherapy

Search more.