The effect of alcoholic cirrhosis on the two kinetic components (high and low affinity) of the microsomal 0-deethylation of 7-ethoxycoumarin in human liver

scientific article published on 01 January 1984

The effect of alcoholic cirrhosis on the two kinetic components (high and low affinity) of the microsomal 0-deethylation of 7-ethoxycoumarin in human liver is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/BF00546710
P698PubMed publication ID6609077

P2093author name stringM D Rawlins
P Wright
O F James
F M Williams
K W Woodhouse
E Mutch
P2860cites workProtein measurement with the Folin phenol reagentQ20900776
The effect of alcoholic cirrhosis on the activities of microsomal aldrin epoxidase, 7-ethoxycoumarin O-de-ethylase and epoxide hydrolase, and on the concentrations of reduced glutathione in human liverQ34512851
An improved assay of 7-ethoxycoumarin O-deethylase activity: induction of hepatic enzyme activity in C57BL/6J and DBA/2J mice by phenobarbital, 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxinQ44446670
Drug metabolism in liver disease: Activity of hepatic microsomal metabolizing enzymesQ46419837
Biphasic O-deethylation of phenacetin and 7-ethoxycoumarin by human and rat liver microsomal fractionsQ47777194
Aldrin epoxidation kinetics in small samples of human liver.Q52531831
Influence of liver disease and environmental factors on hepatic monooxygenase activity in vitroQ71002221
P433issue1
P921main subjectliver cirrhosisQ147778
P304page(s)61-64
P577publication date1984-01-01
P1433published inEuropean Journal of Clinical PharmacologyQ1376707
P1476titleThe effect of alcoholic cirrhosis on the two kinetic components (high and low affinity) of the microsomal 0-deethylation of 7-ethoxycoumarin in human liver
P478volume26

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cites work (P2860)
Q693973047-Ethoxyresorufin deethylase (EROD) in human liver--the effect of alcoholic liver disease
Q39502992Alcohol--a major risk factor for hepatocellular carcinoma?
Q67802319Comparison of in vitro and in vivo biotransformation in patients with liver disease of differing severity
Q34357251Conjugation pathways in liver disease
Q38607515Drug therapy in the geriatric animal: the effect of aging on drug disposition
Q41951404Inhibition of human liver cytochrome P-450 by omeprazole
Q69974926Isolation of human hepatic microsomes and their inhibition by cimetidine and ranitidine
Q36972832The Problems and Pitfalls of NSAID Therapy in the Elderly (Part II)1
Q39689342The disposition of cytotoxic drugs in the elderly
Q34446553The metabolism of 7-ethoxycoumarin in human liver microsomes and the effect of primary biliary cirrhosis: implications for studies of drug metabolism in liver disease
Q39761044The pharmacokinetics of non-steroidal anti-inflammatory drugs in the elderly