Renal disposition and drug interaction screening of (-)-2'-deoxy-3'-thiacytidine (3TC) in the isolated perfused rat kidney

scientific article published on 01 December 1995

Renal disposition and drug interaction screening of (-)-2'-deoxy-3'-thiacytidine (3TC) in the isolated perfused rat kidney is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1023/A:1016252225013
P698PubMed publication ID8786973

P2093author name stringD R Taft
P Statkevich
P H Hsyu
K R Sweeney
P2860cites work(-)-2'-deoxy-3'-thiacytidine is a potent, highly selective inhibitor of human immunodeficiency virus type 1 and type 2 replication in vitroQ28316326
Anti-human immunodeficiency virus type 1 activity and in vitro toxicity of 2'-deoxy-3'-thiacytidine (BCH-189), a novel heterocyclic nucleoside analogQ28333679
The safety and pharmacokinetics of a reverse transcriptase inhibitor, 3TC, in patients with HIV infectionQ28342763
Current status of HIV therapy: I. Antiretroviral agentsQ35335827
Lack of pharmacokinetic interaction between intravenous 2',3'-dideoxyinosine and 3'-azido-3'-deoxythymidine in ratsQ35867338
Pharmacokinetics of 3'-azido-3'-deoxythymidine and its catabolites and interactions with probenecid in rhesus monkeysQ36753621
Infection with the human immunodeficiency virus: epidemiology, pathogenesis, transmission, diagnosis, and manifestationsQ38665617
Metabolic activities of the isolated perfused rat kidneyQ39270810
1 The perfused rat kidneyQ39944363
Pharmacokinetic-interaction study of didanosine and ranitidine in patients seropositive for human immunodeficiency virusQ40088469
Use of the Isolated Perfused Kidney as a Tool in Drug Disposition StudiesQ40166151
Measurement of the renal clearance of drugsQ40329525
Clinical pharmacology of zidovudine and other 2?,3?-dideoxynucleoside analoguesQ40487397
Probenecid and zidovudine metabolismQ42190417
Multiple sodium-dependent nucleoside transport systems in bovine renal brush-border membrane vesiclesQ42859775
Pharmacokinetic Evaluation of Drug Interactions with Zidovudine. I: Probenecid and Zidovudine in MonkeysQ43738146
Competitive inhibition of zidovudine clearance by probenecid during continuous coadministrationQ44477319
Pharmacokinetic evaluation of drug interactions with anti-human immunotrophic virus (HIV) Drugs. III. 2',3'-Dideoxycytidine (ddC) and zidovudine in monkeysQ45880071
Probenecid inhibits the metabolic and renal clearances of zidovudine (AZT) in human volunteersQ46048861
Substrate selectivity, potential sensitivity and stoichiometry of Na(+)-nucleoside transport in brush border membrane vesicles from human kidneyQ46117698
Interaction of 3'-azido-3'-deoxythymidine with organic ion transport in rat renal basolateral membrane vesiclesQ46603353
Nucleoside transport in brush border membrane vesicles from human kidneyQ46684553
Pharmacokinetics of 2',3'-Dideoxycytidine after High-Dose Administration to RatsQ52462768
Influence of probenecid and paracetamol (acetaminophen) on zidovudine glucuronidation in human liver in vitroQ67550740
Nonlinear disposition of intravenous 2',3'-dideoxyinosine in ratsQ67562012
Pharmacokinetic evaluation of drug interactions with anti-HIV drugs, II: Effect of 2',3'-dideoxyinosine (ddI) on zidovudine kinetics in monkeysQ68064039
Alteration of zidovudine pharmacokinetics by probenecid in patients with AIDS or AIDS-related complexQ69384273
Effect of probenecid on the renal and nonrenal clearances of zidovudine and its distribution into cerebrospinal fluid in the rabbitQ69386767
Pharmacokinetics and saturable renal tubular secretion of zidovudine in ratsQ69725262
Improved function with amino acids in the isolated perfused kidneyQ70444032
Characterization of methotrexate elimination and interaction with indomethacin and flurbiprofen in the isolated perfused rat kidneyQ70757438
Automated high-performance liquid chromatographic analysis of (-)-2'-deoxy-3'-thiacytidine in biological fluids using the automated sequential trace enrichment of dialysate systemsQ72177134
Effects of probenecid and cimetidine on the renal excretion of 3'-azido-3'-deoxythymidine in ratsQ72394312
Pharmacokinetics of saccharin in the rat. Renal clearance in vivo and in the isolated perfused kidneyQ72424443
Renal clearance of carprofen in the isolated perfused rat kidneyQ72462660
P433issue12
P921main subjectlamivudineQ422631
P304page(s)1958-1963
P577publication date1995-12-01
P1433published inPharmaceutical ResearchQ7180737
P1476titleRenal disposition and drug interaction screening of (-)-2'-deoxy-3'-thiacytidine (3TC) in the isolated perfused rat kidney
P478volume12

Reverse relations

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