Photoreactive analogues of prenyl diphosphates as inhibitors and probes of human protein farnesyltransferase and geranylgeranyltransferase type I

scientific article published on 01 August 1995

Photoreactive analogues of prenyl diphosphates as inhibitors and probes of human protein farnesyltransferase and geranylgeranyltransferase type I is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.270.32.19035
P698PubMed publication ID7642565

P50authorYuri BukhtiyarovQ40066778
P2093author name stringC M Allen
C A Omer
P2860cites workProtein farnesyltransferase and geranylgeranyltransferase share a common alpha subunitQ24301326
Crystal structure of recombinant farnesyl diphosphate synthase at 2.6-A resolutionQ27730917
Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDaQ27861105
Characterization of recombinant human farnesyl-protein transferase: cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferasesQ28116052
All ras proteins are polyisoprenylated but only some are palmitoylatedQ28270312
Photoaffinity labeling of the catalytic site of prenyltransferaseQ28318417
cDNA cloning of component A of Rab geranylgeranyl transferase and demonstration of its role as a Rab escort proteinQ28569766
Brain G protein gamma subunits contain an all-trans-geranylgeranylcysteine methyl ester at their carboxyl terminiQ33723105
G protein gamma subunits contain a 20-carbon isoprenoidQ33723497
p21ras is modified by a farnesyl isoprenoidQ34315409
Protein isoprenylation and methylation at carboxyl-terminal cysteine residuesQ35671041
A protein geranylgeranyltransferase from bovine brain: implications for protein prenylation specificityQ37532652
C terminus of the small GTP-binding protein smg p25A contains two geranylgeranylated cysteine residues and a methyl esterQ37548646
Enzymatic modification of proteins with a geranylgeranyl isoprenoidQ37599865
The purification of 3,3-dimethylallyl- and geranyl-transferase and of isopentenyl pyrophosphate isomerase from pig liverQ39273396
Inhibitors of Ras farnesyltransferasesQ40778426
Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cellsQ41546925
Inhibition of farnesyl transferases from malignant and non-malignant cultured human lymphocytes by prenyl substrate analoguesQ41836587
Common modifications of trimeric G proteins and ras protein: involvement of polyisoprenylationQ42041959
Anti-Ras drugs come of age.Q46442557
Steady-state kinetic mechanism of Ras farnesyl:protein transferaseQ48492185
Allylic oxidation of olefins by catalytic and stoichiometric selenium dioxide with tert-butyl hydroperoxideQ58005324
Purification and characterization of undecaprenylpyrophosphate synthetaseQ70093803
Pseudopeptide inhibitors of Ras farnesyl-protein transferaseQ72333432
Mammalian protein geranylgeranyltransferase-I: substrate specificity, kinetic mechanism, metal requirements, and affinity labelingQ72422653
P433issue32
P407language of work or nameEnglishQ1860
P304page(s)19035-19040
P577publication date1995-08-01
P1433published inJournal of Biological ChemistryQ867727
P1476titlePhotoreactive analogues of prenyl diphosphates as inhibitors and probes of human protein farnesyltransferase and geranylgeranyltransferase type I
P478volume270

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cites work (P2860)
Q43556623Anions modulate the potency of geranylgeranyl-protein transferase I inhibitors
Q38732297Diazirine-containing photoactivatable isoprenoid: synthesis and application in studies with isoprenylcysteine carboxyl methyltransferase
Q42173735Interacting targets of the farnesyl of transducin gamma-subunit.
Q54223105Isoprenoids and protein prenylation: implications in the pathogenesis and therapeutic intervention of Alzheimer's disease.
Q43720096Modification of Rab5 with a photoactivatable analog of geranylgeranyl diphosphate
Q73813776Mutational analysis of conserved residues of the beta-subunit of human farnesyl:protein transferase
Q41685107Protein farnesyltransferase
Q34992469Protein prenylation: enzymes, therapeutics, and biotechnology applications
Q47829646Protein prenylation: from discovery to prospects for cancer treatment.
Q27658404Synthesis, Properties, and Applications of Diazotrifluropropanoyl-Containing Photoactive Analogs of Farnesyl Diphosphate Containing Modified Linkages for Enhanced Stability

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