Probing the structure of hirudin from Hirudinaria manillensis by limited proteolysis. Isolation, characterization and thrombin-inhibitory properties of N-terminal fragments

scientific article published on 01 December 1994

Probing the structure of hirudin from Hirudinaria manillensis by limited proteolysis. Isolation, characterization and thrombin-inhibitory properties of N-terminal fragments is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/J.1432-1033.1994.TB20056.X
P698PubMed publication ID8001550

P50authorGiuseppe ZanottiQ28037254
P2093author name stringA Fontana
C Visco
A Vindigni
V De Filippis
G Orsini
P433issue2
P921main subjectproteolysisQ33123
hirudinQ386715
P304page(s)323-333
P577publication date1994-12-01
P1433published inFEBS JournalQ1388041
P1476titleProbing the structure of hirudin from Hirudinaria manillensis by limited proteolysis. Isolation, characterization and thrombin-inhibitory properties of N-terminal fragments
P478volume226

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cites work (P2860)
Q79779483Arhynchobdellida (Annelida: Oligochaeta: Hirudinida): phylogenetic relationships and evolution
Q36280807Chemical synthesis and structural characterization of the RGD-protein decorsin: a potent inhibitor of platelet aggregation
Q57961081Conformational Stability Is a Determinant of Ribonuclease A Cytotoxicity
Q33195600Directed evolution towards protease-resistant hirudin variants
Q79279714Gastrointestinal Absorption of Recombinant Hirudin-2 in Rats
Q36281273Incorporation of noncoded amino acids into the N-terminal domain 1-47 of hirudin yields a highly potent and selective thrombin inhibitor.
Q36519387Incorporation of the fluorescent amino acid 7-azatryptophan into the core domain 1-47 of hirudin as a probe of hirudin folding and thrombin recognition
Q54589184Investigation on minor degraded derivatives of the recombinant hirudin variant HM2 from Hirudinaria manillensis isolated by isoelectric focusing in multicompartment electrolyzers.
Q36282292Limited proteolysis of ribonuclease A with thermolysin in trifluoroethanol
Q27714094Loop Electrostatics Asymmetry Modulates the Preexisting Conformational Equilibrium in Thrombin
Q36857390NMR solution structure of a novel hirudin variant HM2, N-terminal 1-47 and N64-->V + G mutant
Q38410604Pharmacology and controlled release of hirudin for cardiovascular disorders
Q41458691Probing the partly folded states of proteins by limited proteolysis
Q41738009The structural aspects of limited proteolysis of native proteins

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