Carbacyclin--a potent stable prostacyclin analogue for the inhibition of platelet aggregation

scientific article published on 01 April 1980

Carbacyclin--a potent stable prostacyclin analogue for the inhibition of platelet aggregation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S0090-6980(80)80010-4
P698PubMed publication ID6992234

P50authorJohn VaneQ309971
P2093author name stringS Moncada
B J Whittle
F Whiting
P2860cites workCirculatory and anti-platelet effects of intravenous prostacyclin in healthy menQ40937898
Actions of prostacyclin (PGI2) and its product, 6-oxo-PGF1α on the rat gastric mucosa in vivo and in vitroQ40938331
Comparison of the effects of prostacyclin (PGI2), prostaglandin E1 and D2 on platelet aggregation in different speciesQ40971810
Desensitization of prostaglandin-activated platelet adenylate cyclaseQ41708054
Preservation of human platelets with prostaglandin E1 during in vitro simulation of cardiopulmonary bypassQ43871309
Prostaglandins: Their Disappearance from and Release into the CirculationQ59078578
Synthesis and sterochemistry of prostacyclin and synthesis of 6-ketoprostagliandin F1alphaQ67577194
Prostacyclin to prevent platelet activation during charcoal haemoperfusion in fulminant hepatic failureQ72418766
An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregationQ28244623
Prostacyclin can replace heparin in haemodialysis in dogsQ33492862
The chemical structure of prostaglandin X (prostacyclin)Q39128911
The relative activity of prostacyclin (PGI2) and a stable analogue 6β-PGI1 on the gastrointestinal and cardiovascular systemsQ39209100
Prostacyclin: a solution to some problems of extracorporeal circulation. Experiments in greyhoundsQ39544596
Successful therapy of advanced arteriosclerosis obliterans with prostacyclinQ39545073
Comparison of the vasodepressor effects of prostacyclin and 6-oxo-prostaglandin F1alpha with those of prostaglandin E2 in rats and rabbitsQ40034246
Modulation of human platelet adenylate cyclase by prostacyclin (PGX)Q40061238
Effects of prostacyclin (PGX) on cyclic AMP concentrations in human plateletsQ40061244
Studies of the mechanisms involved in the fate of prostacyclin (PGI2) and 06-keto-PGF1α in the pulmonary circulationQ40220109
P433issue4
P921main subjectplatelet aggregationQ14913634
P304page(s)605-627
P577publication date1980-04-01
P1433published inProstaglandinsQ24054793
P1476titleCarbacyclin--a potent stable prostacyclin analogue for the inhibition of platelet aggregation
P478volume19

Reverse relations

cites work (P2860)
Q42566054(5Z)-carbacyclin discriminates between prostacyclin-receptors coupled to adenylate cyclase in vascular smooth muscle and platelets
Q40204869Antithrombotic assessment and clinical potential of prostacyclin analogues.
Q41884851Characterization of the PGE2 receptor subtype in bovine chondrocytes in culture
Q39739043Current issues in thrombosis prevention with antiplatelet drugs
Q70347430Cyclooxygenase inhibition reduces placental transfer: reversal by carbacyclin
Q35574131Cyclooxygenase-2 modulates cellular growth and promotes tumorigenesis.
Q36097438Desensitization of prostacyclin receptors in a neuronal hybrid cell line
Q41262139Effect of prostanoids on renin release from rabbit afferent arterioles with and without macula densa
Q42240401Effects of SQ 27,427, a thromboxane A2 receptor antagonist, in the human platelet and isolated smooth muscle
Q37393089Hemostatic mechanisms, independent of platelet aggregation, arrest gastric mucosal bleeding
Q73026236Inhibition of GABA-gated chloride channels in brain by the arachidonic acid metabolite, thromboxane A2
Q35876629Inhibition of inositol 1,4,5-trisphosphate-induced Ca2+ release by cAMP-dependent protein kinase in a living cell
Q71448562Inhibition of platelet aggregation and reversal of vasopressin-induced ECG changes by a carboprostacyclin analogue, ONO 41483, in primates
Q42126640Interaction of prostaglandin D2 with prostacyclin, carbacyclin and the hydantoin prostaglandin, BW245C, in guinea-pig platelets
Q37084924Long-term exposure to PGE2 causes homologous desensitization of receptor-mediated activation of protein kinase A.
Q60731511Mechano- and chemosensitivity of rat nodose neurones--selective excitatory effects of prostacyclin
Q70259759Platelet and cardiovascular activity of the hydantoin BW245C, a potent prostaglandin analogue
Q41639777Platelet prostanoid receptors
Q42066683Prostacyclin analogs inhibit fibroblast contraction of collagen gels through the cAMP-PKA pathway
Q70319609Prostacyclin and its Analogues for the Therapy of Thromboembolic Disorders
Q72919322Some biochemical activities of 10,10-Difluoro-13-dehydroprostacyclin, a chemically stable analog of prostacyclin, in human blood platelets
Q42813297Stimulation of fat storage by prostacyclin and selective agonists of prostanoid IP receptor during the maturation phase of cultured adipocytes.
Q27670895Structural Basis for Iloprost as a Dual Peroxisome Proliferator-activated Receptor  /  Agonist
Q72639709The antiplatelet and cardiovascular actions of a new carbacyclin derivative (ZK 36 374)--equipotent to PGI2 in vitro
Q35886537The cardiovascular and platelet actions of 9 beta-methyl carbacyclin (ciprostene), a chemically stable analogue of prostacyclin, in the dog and monkey
Q70314047The effect of carbacyclin, a prostaglandin analogue, on adenylate cyclase activity in platelet membranes
Q48611576The use of a prostacyclin analogue, [3H]iloprost, for studying prostacyclin-binding sites on human platelets and neuronal hybrid cells
Q33918377Thrombosis is reduced by inhibition of COX-1, but unaffected by inhibition of COX-2, in an acute model of platelet activation in the mouse
Q59099057Vasoconstriction with thromboxane A2 induces ulceration of the gastric mucosa
Q35887613Vasodilator actions of TRK-100, a new prostaglandin I2 analogue
Q54125809cGMP inhibits IP3-induced Ca2+ release in intact rat megakaryocytes via cGMP- and cAMP-dependent protein kinases.