Amplification and overexpression of cyclin D1 in breast cancer detected by immunohistochemical staining

scientific article published on 01 April 1994

Amplification and overexpression of cyclin D1 in breast cancer detected by immunohistochemical staining is …
instance of (P31):
scholarly articleQ13442814

External links are
P698PubMed publication ID8137296

P2093author name stringSmith R
Peters G
Fisher C
Dickson C
Barnes D
Fantl V
Bartek J
Gillett C
P4510describes a project that usesimmunohistochemistryQ899285
P433issue7
P921main subjectbreast cancerQ128581
immunohistochemistryQ899285
P304page(s)1812-1817
P577publication date1994-04-01
P1433published inCancer ResearchQ326097
P1476titleAmplification and overexpression of cyclin D1 in breast cancer detected by immunohistochemical staining
P478volume54

Reverse relations

cites work (P2860)
Q36134760A clinicopathological study on overexpression of cyclin D1 and of p53 in a series of 248 patients with operable breast cancer
Q38582323A genome-wide map of aberrantly expressed chromosomal islands in colorectal cancer
Q85768358A possible usage of a CDK4 inhibitor for breast cancer stem cell-targeted therapy
Q24314746A role for candidate tumor-suppressor gene TCEAL7 in the regulation of c-Myc activity, cyclin D1 levels and cellular transformation
Q33997396A specific role for cyclin D1 in mammary gland development
Q37580471Aberrant expression of cyclin D1 in cancer
Q36422016Abnormal expression of CCND1 and RB1 in resection margin epithelia of lung cancer patients
Q33918764Absence of CCND1 gene amplification in breast tumours of BRCA1 mutation carriers
Q34026139Acetonic extract of Buxus sempervirens induces cell cycle arrest, apoptosis and autophagy in breast cancer cells
Q40848979Amplification and overexpression of the cyclin D1 gene in head and neck squamous cell carcinoma
Q35763656Amplification of CCND1 and expression of its protein product, cyclin D1, in ductal carcinoma in situ of the breast
Q21195209Anterior gradient-2 plays a critical role in breast cancer cell growth and survival by modulating cyclin D1, estrogen receptor-alpha and survivin
Q41613251Anticancer activity of calyx of Diospyros kaki Thunb. through downregulation of cyclin D1 via inducing proteasomal degradation and transcriptional inhibition in human colorectal cancer cells
Q93089128Are all cyclin-dependent kinases 4/6 inhibitors created equal?
Q58552901Association between G870A (rs9344) polymorphism and cancer risk in Indian population: Meta-analysis and Trial Sequential Analysis
Q39076047Association of CCND1 Gene c.870G>A Polymorphism with Breast Cancer Risk: A Case-ControlStudy and a Meta-Analysis
Q64087952Association of FOSL1 copy number alteration and triple negative breast tumors
Q42316312Association of ICAM-1, VCAM-1, CYCLIN D1 and Cathepsin D with Clinicopathological Parameters in Breast Carcinoma; an Immunohistochemical Study
Q34064538BRCA1 transcriptionally regulates genes involved in breast tumorigenesis
Q34543461Beta-catenin and Tcfs in mammary development and cancer
Q35679187Beta-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression
Q27852008Biomarkers for the clinical management of breast cancer: International perspective
Q34101905Boswellia sacra essential oil induces tumor cell-specific apoptosis and suppresses tumor aggressiveness in cultured human breast cancer cells
Q35624792Breaking the cycle: An insight into the role of ERα in eukaryotic cell cycles
Q34036076CDK4 inhibition and doxorubicin mediate breast cancer cell apoptosis through Smad3 and survivin.
Q57107726CDK4/6 inhibitors in the treatment of patients with breast cancer: summary of a multidisciplinary round-table discussion
Q39601717Cell Cycle Protein Cyclin Y Is Associated With Human Non–Small-Cell Lung Cancer Proliferation and Tumorigenesis
Q34076478Cell cycle checkpoints and their inactivation in human cancer
Q33588357Cell cycle regulators and their abnormalities in breast cancer
Q40524872Chromosome 11q13 markers and D-type cyclins in breast cancer
Q36431072Classical gene amplifications in human breast cancer are not associated with distant solid metastases
Q92029556Clinical significance of the histological and molecular characteristics of ependymal tumors: a single institution case series from China
Q36238230Clinico-prognostic value of D-type cyclins and p27 in laryngeal cancer patients: a review
Q37030174Comparison of Her-2, EGFR and cyclin D1 in primary breast cancer and paired metastatic lymph nodes: an immunohistochemical and chromogenic in situ hybridization study
Q34579889Constitutive CCND1/CDK2 Activity Substitutes for p53 Loss, or MYC or Oncogenic RAS Expression in the Transformation of Human Mammary Epithelial Cells
Q36634397Correlation between cyclin D1 expression and standard clinicopathological variables in invasive breast cancer in Eastern India
Q37640655Correlation of cyclin D1 and Rb gene expression with apoptosis in invasive breast cancer
Q58585562Cow-to-mouse fecal transplantations suggest intestinal microbiome as one cause of mastitis
Q24803368Cyclin A and cyclin D1 as significant prognostic markers in colorectal cancer patients
Q24644847Cyclin D1 Stimulation of Estrogen Receptor Transcriptional Activity Independent of cdk4†
Q33840107Cyclin D1 amplification and expression in human breast carcinoma: correlation with histological prognostic markers and oestrogen receptor expression
Q40794379Cyclin D1 and human neoplasia
Q24796232Cyclin D1 and mammary carcinoma: new insights from transgenic mouse models
Q35764646Cyclin D1 expression in invasive breast cancer. Correlations and prognostic value.
Q36622503Cyclin D1 expression in transitional cell carcinoma of the bladder: correlation with p53, waf1, pRb and Ki67.
Q36641208Cyclin D1 overexpression is an indicator of poor prognosis in resectable non-small cell lung cancer
Q36294947Cyclin D1 overexpression related to retinoblastoma protein expression as a prognostic marker in human oesophageal squamous cell carcinoma
Q35788347Cyclin D1 polymorphism and expression in patients with squamous cell carcinoma of the head and neck
Q38834030Cyclin D1 promotes BRCA2-Rad51 interaction by restricting cyclin A/B-dependent BRCA2 phosphorylation
Q38471118Cyclin D1 protein overexpression is related to tumor differentiation, but not to tumor progression or proliferative activity, in transitional cell carcinoma of the bladder
Q41578764Cyclin D1/PRAD1 as a central target in oncogenesis
Q34775678Cyclin D1b protein expression in breast cancer is independent of cyclin D1a and associated with poor disease outcome
Q35745372Cyclin D2 overexpression and lack of p27 correlate positively and cyclin E inversely with a poor prognosis in gastric cancer cases
Q34582060Cyclin T1 overexpression induces malignant transformation and tumor growth
Q51363759Cyclin d1 expression and its correlation with histopathological differentiation in oral squamous cell carcinoma
Q73973164Cyclins and breast cancer
Q79922062Cyclins and breast cancer
Q51738323Cytotoxic activity of the twigs of Cinnamomum cassia through the suppression of cell proliferation and the induction of apoptosis in human colorectal cancer cells
Q36206691Differential control of growth, apoptotic activity, and gene expression in human breast cancer cells by extracts derived from medicinal herbs Zingiber officinale.
Q33566343Disrupting the Rb-Raf-1 interaction: a potential therapeutic target for cancer
Q36160923Dissecting the roles of beta-catenin and cyclin D1 during mammary development and neoplasia
Q33899840E2F activators signal and maintain centrosome amplification in breast cancer cells
Q36565534E2F-1 cooperates with topoisomerase II inhibition and DNA damage to selectively augment p53-independent apoptosis
Q36621254ERBB-2 overexpression confers PI 3' kinase-dependent invasion capacity on human mammary epithelial cells
Q39797974ERK activation and cell growth require CaM kinases in MCF-7 breast cancer cells
Q47424104ETV4 Facilitates Cell-Cycle Progression in Pancreatic Cells through Transcriptional Regulation of Cyclin D1.
Q34606102Effects of body-resistance strengthening and tumor-suppressing granules on immune adhesion function of red blood cells and expression of metastasis protein CD44 in tumor cells of patients with esophageal carcinoma
Q36245589Effects of cyclin D1 gene amplification and protein expression on time to recurrence in postmenopausal breast cancer patients treated with anastrozole or tamoxifen: a TransATAC study
Q73662909Environmental chemical carcinogens induce transformation of breast epithelial cells from women with familial history of breast cancer
Q47551153Estrogen Receptor-Positive Breast Cancer: Exploiting Signaling Pathways Implicated in Endocrine Resistance
Q39106448Euphol arrests breast cancer cells at the G1 phase through the modulation of cyclin D1, p21 and p27 expression
Q56516873Evaluation of the Role Played by Cyclin D1 as a Diagnostic and Prognostic Marker in the Progression of Oral Carcinogenesis
Q91928964Exploring the Molecular Mechanism of the Drug-Treated Breast Cancer Based on Gene Expression Microarray
Q36641066Expression and subcellular localization of cyclin D1 protein in epithelial ovarian tumour cells
Q24678067Expression of the G2-M checkpoint regulators cyclin B1 and cdc2 in nonmalignant and malignant human breast lesions: immunocytochemical and quantitative image analyses
Q61797237Extracts from Sageretia thea reduce cell viability through inducing cyclin D1 proteasomal degradation and HO-1 expression in human colorectal cancer cells
Q57793316Frequent ESR1 and CDK Pathway Copy Number Alterations in Metastatic Breast Cancer
Q41332206Frequent amplification of the cyclin E gene in human gastric carcinomas
Q27013811GSK-3 as potential target for therapeutic intervention in cancer
Q35793260Gene amplification and overexpression of CDK4 in sporadic breast carcinomas is associated with high tumor cell proliferation
Q33962744Genetic analysis of breast cancer progression
Q35146602Genetically engineered mice as experimental tools to dissect the critical events in breast cancer
Q38502919Genome-wide screening of indicator genes for assessing the potential carcinogenic risk of Nanjing city drinking water
Q26738987Genomic Changes in Normal Breast Tissue in Women at Normal Risk or at High Risk for Breast Cancer
Q36184676High level expression of p27(kip1) and cyclin D1 in some human breast cancer cells: inverse correlation between the expression of p27(kip1) and degree of malignancy in human breast and colorectal cancers
Q90441662Human amniotic membrane conditioned medium inhibits proliferation and modulates related microRNAs expression in hepatocarcinoma cells
Q35076272Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells.
Q43851743IGF‐1 induces Pin1 expression in promoting cell cycle S‐phase entry
Q55026872Immunohistochemical analysis of cyclin D1 protein in hematopoietic neoplasms with special reference to mantle cell lymphoma.
Q38477902Immunohistochemistry of cyclin D3 in pulmonary carcinomas
Q43701627In vivo analysis of mammary and non-mammary tumorigenesis in MMTV-cyclin D1 transgenic mice deficient in p53
Q42324488Increase of the therapeutic effect on non-small-cell lung cancer cells with combination treatment of shRNA against Cyclin D1 and Bcl-xL in vitro
Q33919283Increased cyclin D1 expression in cancer of the ampulla of Vater: relevance to nuclear beta catenin accumulation and k-ras gene mutation
Q53403192Increased expression of cyclin D1, cyclin E and p21(Cip1) associated with decreased expression of p27(Kip1) in chemically induced rat mammary carcinogenesis
Q36081611Infrequent CDKN2 (MTS1/p16) gene alterations in human primary breast cancer
Q37376213Inhibition of PHLPP2/cyclin D1 protein translation contributes to the tumor suppressive effect of NFκB2 (p100).
Q34122589Inhibition of cyclin D1 expression by androgen receptor in breast cancer cells--identification of a novel androgen response element
Q36580735Integration of progesterone receptor action with rapid signaling events in breast cancer models
Q47835152Inverse Association Between Cyclin D1 Overexpression and Retinoblastoma Gene Mutation in Thyroid Carcinomas
Q34613461Key signaling nodes in mammary gland development and cancer: β-catenin
Q36473652Knockdown of TMEM16A suppressed MAPK and inhibited cell proliferation and migration in hepatocellular carcinoma
Q34677472Lactation defect in mice lacking the helix-loop-helix inhibitor Id2
Q36462357Leptin regulates cyclin D1 in luminal epithelial cells of mouse MMTV-Wnt-1 mammary tumors
Q24595709Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1
Q34009230Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes
Q34813351Loss of caveolin-1 gene expression accelerates the development of dysplastic mammary lesions in tumor-prone transgenic mice
Q33830304MUC1 regulates nuclear localization and function of the epidermal growth factor receptor
Q36753508MUC1-C oncoprotein as a target in breast cancer: activation of signaling pathways and therapeutic approaches
Q35879924MUC1-C oncoprotein induces TCF7L2 transcription factor activation and promotes cyclin D1 expression in human breast cancer cells
Q92512968Mechanisms of Resistance to CDK4/6 Inhibitors: Potential Implications and Biomarkers for Clinical Practice
Q33631775Minireview: Tipping the balance: ligand-independent activation of steroid receptors
Q36772197Mitochondrial reactive oxygen species perturb AKT/cyclin D1 cell cycle signaling via oxidative inactivation of PP2A in lowdose irradiated human fibroblasts.
Q37485770Modeling breast cancer in vivo and ex vivo reveals an essential role of Pin1 in tumorigenesis
Q92238135Modeling the Dynamics of Let-7-Coupled Gene Regulatory Networks Linking Cell Proliferation to Malignant Transformation
Q37535523Modulation of cyclins, p53 and mitogen-activated protein kinases signaling in breast cancer cell lines by 4-(3,4,5-trimethoxyphenoxy)benzoic acid
Q59791901Moving Breast Cancer Therapy up a Notch
Q35798342Mutations of cell cycle regulators. Biological and clinical implications for human neoplasia
Q37610084Neem leaf extract inhibits mammary carcinogenesis by altering cell proliferation, apoptosis, and angiogenesis
Q86277819No difference in CCND1 gene expression between breast cancer patients with and without lymph node metastasis in a Southern Brazilian sample
Q24303548Nuclear Cyclin D1/CDK4 Kinase Regulates CUL4 Expression and Triggers Neoplastic Growth via Activation of the PRMT5 Methyltransferase
Q39258788Nuclear accumulation of cyclin D1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA rereplication
Q37470373Nuclear cyclin D1: an oncogenic driver in human cancer
Q36065105Nucleolar GTP-binding Protein-1 (NGP-1) Promotes G1 to S Phase Transition by Activating Cyclin-dependent Kinase Inhibitor p21 Cip1/Waf1.
Q36420373Overcoming Endocrine Resistance in Hormone-Receptor Positive Advanced Breast Cancer-The Emerging Role of CDK4/6 Inhibitors
Q55710176Overcoming Therapeutic Resistance of Triple Positive Breast Cancer with CDK4/6 Inhibition.
Q35795143Overexpression and localization of cyclin D1 mRNA and antigen in esophageal cancer.
Q41855173Overexpression of cyclin D1 correlates with early recurrence in superficial bladder cancers
Q73630327Overexpression of cyclin D1 mRNA in colorectal carcinomas and relationship to clinicopathological features: an in situ hybridization analysis
Q21195212PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro
Q59808745PIN1 in Cell Cycle Control and Cancer
Q34283602PIN1 is an E2F target gene essential for Neu/Ras-induced transformation of mammary epithelial cells
Q28387216Panepoxydone targets NF-kB and FOXM1 to inhibit proliferation, induce apoptosis and reverse epithelial to mesenchymal transition in breast cancer
Q38946190Parkin and mitophagy in cancer.
Q36329257Peripheral T-cell Lymphoma with Cyclin D1 overexpression: a case report.
Q40486142Phosphorylation of progesterone receptor serine 400 mediates ligand-independent transcriptional activity in response to activation of cyclin-dependent protein kinase 2.
Q24535558Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1.
Q34078491Polyphenon E inhibits the growth of human Barrett's and aerodigestive adenocarcinoma cells by suppressing cyclin D1 expression
Q21285102Pomegranate Juice Metabolites, Ellagic Acid and Urolithin A, Synergistically Inhibit Androgen-Independent Prostate Cancer Cell Growth via Distinct Effects on Cell Cycle Control and Apoptosis
Q35150980Prevention of Bronchial Hyperplasia by EGFR Pathway Inhibitors in an Organotypic Culture Model
Q77683176Prognosis and prediction of response in breast cancer: the current role of the main biological markers
Q34086636Prognostic biomarkers in ovarian cancer
Q36134992Prognostic significance of CCND1 (cyclin D1) overexpression in primary resected non-small-cell lung cancer
Q36291799Prognostic significance of cyclin E and p53 protein overexpression in carcinoma of the renal pelvis and ureter
Q36644111Prognostic value of CCND1 gene status in sporadic breast tumours, as determined by real-time quantitative PCR assays
Q37632170Progress with palbociclib in breast cancer: latest evidence and clinical considerations
Q33859439Regulation of Glioblastoma Progression by Cord Blood Stem Cells Is Mediated by Downregulation of Cyclin D1
Q24791043Regulation of Id2 expression by CCAAT/enhancer binding protein beta
Q33635621Regulation of hormonal therapy resistance by cell cycle machinery
Q33966444Regulation of the functional interaction between cyclin D1 and the estrogen receptor
Q36028468Retinoblastoma tumor-suppressor protein phosphorylation and inactivation depend on direct interaction with Pin1.
Q37536936Role of cyclin D1 in breast carcinoma
Q34452617SLUG-induced elevation of D1 cyclin in breast cancer cells through the inhibition of its ubiquitination.
Q89903809SPH3643: A novel cyclin-dependent kinase 4/6 inhibitor with good anticancer efficacy and strong blood-brain barrier permeability
Q36917747Sequential Combination Therapy of CDK Inhibition and Doxorubicin Is Synthetically Lethal in p53-Mutant Triple-Negative Breast Cancer
Q37071327Silencing CDK4 radiosensitizes breast cancer cells by promoting apoptosis
Q34989052Silencing of the IKKε gene by siRNA inhibits invasiveness and growth of breast cancer cells
Q35607385Stromal and epithelial caveolin-1 both confer a protective effect against mammary hyperplasia and tumorigenesis: Caveolin-1 antagonizes cyclin D1 function in mammary epithelial cells
Q36798059TRIM16 inhibits neuroblastoma cell proliferation through cell cycle regulation and dynamic nuclear localization
Q34040108Tailoring to RB: tumour suppressor status and therapeutic response
Q34387697Targeted silencing of elongation factor 2 kinase suppresses growth and sensitizes tumors to doxorubicin in an orthotopic model of breast cancer
Q26827580Targeting cyclin-dependent kinases in human cancers: from small molecules to Peptide inhibitors
Q33886076The Cytoplasmic Domain of MUC1 Induces Hyperplasia in the Mammary Gland and Correlates with Nuclear Accumulation of β-Catenin
Q28592198The Fbx4 Tumor Suppressor Regulates Cyclin D1 Accumulation and Prevents Neoplastic Transformation
Q55237298The Positive Nuclear Staining Observed with Monoclonal Antibody against PRAD1/Cyclin D1 Correlates with mRNA Expression in Mantle Cell Lymphoma
Q41528803The Retinoblastoma Protein: A Master Regulator of Cell Cycle, Differentiation and Apoptosis
Q36186374The cyclin D1-CDK4 oncogenic interactome enables identification of potential novel oncogenes and clinical prognosis
Q37122778The expression status of TRX, AR, and cyclin D1 correlates with clinicopathological characteristics and ER status in breast cancer
Q40442663The involvement of the chromosome 11q13 region in human malignancies: Cyclin D1 and EMS1 are two new candidate oncogenes-a review
Q64086537The long-term prognostic and predictive capacity of cyclin D1 gene amplification in 2305 breast tumours
Q55033417The prolactin receptor transactivation domain is associated with steroid hormone receptor expression and malignant progression of breast cancer.
Q24795560The prolyl isomerase Pin1 in breast development and cancer
Q21245733The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic invention
Q78828706The relationship of CyclinD1 and estrogen receptor expression in the process of proliferation and metastasis in breast neoplasm
Q37505500The role of cyclin D1 in response to long-term exposure to ionizing radiation
Q36254816The role of oncogenes in drug resistance
Q41205948The role of the cell cycle in genitourinary carcinoma
Q38694659The role of β-catenin in the initiation and metastasis of TA2 mice spontaneous breast cancer
Q33959317Transgenic mice reveal roles for TGFalpha and EGF receptor in mammary gland development and neoplasia
Q33236460Transgenic mice with mammary gland targeted expression of human cortactin do not develop (pre-malignant) breast tumors: studies in MMTV-cortactin and MMTV-cortactin/-cyclin D1 bitransgenic mice
Q38794109Treating cancer with selective CDK4/6 inhibitors
Q35639956Tumor-suppressive Effects of Psoriasin (S100A7) Are Mediated through the β-Catenin/T Cell Factor 4 Protein Pathway in Estrogen Receptor-positive Breast Cancer Cells
Q37296321URG11 promotes gastric cancer growth and invasion by activation of beta-catenin signalling pathway
Q64890070Updates on the CDK4/6 Inhibitory Strategy and Combinations in Breast Cancer.
Q34789986Use of three-dimensional basement membrane cultures to model oncogene-induced changes in mammary epithelial morphogenesis
Q37135253Validation study of the prognostic value of cyclin-dependent kinase (CDK)-based risk in Caucasian breast cancer patients
Q41145371Voltage-gated calcium channels: Novel targets for cancer therapy
Q33618690Wnt signaling activation and mammary gland hyperplasia in MMTV-LRP6 transgenic mice: implication for breast cancer tumorigenesis
Q38807957Wnt/β-catenin signaling plays an ever-expanding role in stem cell self-renewal, tumorigenesis and cancer chemoresistance.
Q51392053γ-Tocotrienol prevents cell cycle arrest in aged human fibroblast cells through p16INK4a pathway.

Search more.