5-Aza-2'-deoxycytidine induces terminal differentiation of leukemic blasts from patients with acute myeloid leukemias

scientific article published on 01 October 1984

5-Aza-2'-deoxycytidine induces terminal differentiation of leukemic blasts from patients with acute myeloid leukemias is …
instance of (P31):
scholarly articleQ13442814

External links are
P698PubMed publication ID6206904

P2093author name stringP P Di Fiore
F Ferrara
A Pinto
A Fusco
V Attadia
O A Spada
P433issue4
P304page(s)922-929
P577publication date1984-10-01
P1433published inBloodQ885070
P1476title5-Aza-2'-deoxycytidine induces terminal differentiation of leukemic blasts from patients with acute myeloid leukemias
P478volume64

Reverse relations

cites work (P2860)
Q354234705-aza-2'-deoxycytidine activates iron uptake and heme biosynthesis by increasing c-Myc nuclear localization and binding to the E-boxes of transferrin receptor 1 (TfR1) and ferrochelatase (Fech) genes.
Q33332587A phase I trial of cisplatin plus decitabine, a new DNA-hypomethylating agent, in patients with advanced solid tumors and a follow-up early phase II evaluation in patients with inoperable non-small cell lung cancer
Q24170503Aberrant gene expression in human non small cell lung carcinoma cells exposed to demethylating agent 5-aza-2 '-deoxycytidine
Q35348043Cancer epigenetics: linking basic biology to clinical medicine.
Q36466174Carcinogenicity and haemoglobin synthesis induction by cytidine analogues
Q39139055CpG methylation patterns and decitabine treatment response in acute myeloid leukemia cells and normal hematopoietic precursors
Q40997606Decitabine maintains hematopoietic precursor self-renewal by preventing repression of stem cell genes by a differentiation-inducing stimulus
Q36284232Decitabine: a historical review of the development of an epigenetic drug
Q33407030Decitabine: a review of its use in older patients with acute myeloid leukaemia
Q33678040Demethylating Agents in the Treatment of Cancer
Q35750354Effects of tetrahydrouridine on pharmacokinetics and pharmacodynamics of oral decitabine
Q35742564Efficacy and safety of decitabine in combination with G-CSF, low-dose cytarabine and aclarubicin in newly diagnosed elderly patients with acute myeloid leukemia
Q37381606Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT Inhibitor Decitabine.
Q35825522Emerging therapies in hematopoietic stem cell transplantation
Q33621141Epigenetic therapies for chemoresensitization of epithelial ovarian cancer.
Q33863567Epigenetic therapies in MDS and AML
Q38112417Epigenetic therapy in allogeneic hematopoietic stem cell transplantation
Q26745709Epigenetic therapy in gastrointestinal cancer: the right combination
Q38332497Epigenetic therapy of cancer stem and progenitor cells by targeting DNA methylation machineries
Q37184917Epigenetic treatment of myelodysplastic syndromes and acute myeloid leukemias
Q37964702Epigenetic-based therapies in cancer: progress to date
Q36914167Gamma interferon and 5-azacytidine cause transcriptional elevation of class I major histocompatibility complex gene expression in K562 leukemia cells in the absence of differentiation
Q37099599Gene Expression and Methylation Pattern in HRK Apoptotic Gene in Myelodysplastic Syndrome
Q38529787Importance of dose-schedule of 5-aza-2'-deoxycytidine for epigenetic therapy of cancer
Q37098221Induction of acute lymphocytic leukemia differentiation by maintenance therapy
Q92382685Influence of demethylation on regulatory T and Th17 cells in myelodysplastic syndrome
Q36416358Is targeted therapy feasible in acute myelogenous leukemia?
Q36412709Low concentrations of 5-aza-2'-deoxycytidine induce breast cancer stem cell differentiation by triggering tumor suppressor gene expression
Q33861150Low-dose azacitidine after allogeneic stem cell transplantation for acute leukemia
Q33391089Maintenance therapy with low-dose azacitidine after allogeneic hematopoietic stem cell transplantation for recurrent acute myelogenous leukemia or myelodysplastic syndrome: a dose and schedule finding study
Q26851510New answers to old questions from genome-wide maps of DNA methylation in hematopoietic cells
Q38172875Novel therapeutic strategies using hypomethylating agents in the treatment of myelodysplastic syndrome
Q43247519Pharmacokinetic and pharmacodynamic analysis of 5-aza-2'-deoxycytidine (decitabine) in the design of its dose-schedule for cancer therapy.
Q38155455Relapsed and refractory pediatric acute myeloid leukemia: current and emerging treatments
Q39331564Selected drugs with reported secondary cell-differentiating capacity prime latent HIV-1 infection for reactivation
Q33847891Sequential combination of decitabine and idarubicin synergistically enhances anti-leukemia effect followed by demethylating Wnt pathway inhibitor promoters and downregulating Wnt pathway nuclear target
Q37060639The effects of 5-azacytidine on the function and number of regulatory T cells and T-effectors in myelodysplastic syndrome
Q37765469Therapy with azanucleosides for myelodysplastic syndromes
Q41966277Transbuccal delivery of 5-aza-2 -deoxycytidine: effects of drug concentration, buffer solution, and bile salts on permeation
Q36890276p53 independent epigenetic-differentiation treatment in xenotransplant models of acute myeloid leukemia.
Q36848202p53-Independent, normal stem cell sparing epigenetic differentiation therapy for myeloid and other malignancies