Monocytes are primed to produce the Th1 type cytokine IL-12 in normal human pregnancy: an intracellular flow cytometric analysis of peripheral blood mononuclear cells

scientific article published on 01 March 2003

Monocytes are primed to produce the Th1 type cytokine IL-12 in normal human pregnancy: an intracellular flow cytometric analysis of peripheral blood mononuclear cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1046/J.1365-2249.2003.02082.X
P698PubMed publication ID12605703

P2093author name stringC W G Redman
I L Sargent
G P Sacks
P2860cites workIntracellular cytokine production by human CD4+ and CD8+ T cells from normal and immunodeficient donors using directly conjugated anti-cytokine antibodies and three-colour flow cytometryQ71537265
Flow cytometric analysis for cytokine production identifies T helper 1, T helper 2, and T helper 0 cells within the human CD4+CD27- lymphocyte subpopulationQ72169032
Immunoreactive tumor necrosis factor-alpha is elevated in maternal plasma but undetected in amniotic fluid in the second trimesterQ72761569
Predominance of type 2 cytokine-producing CD4+ and CD8+ cells in patients with atopic dermatitisQ73348117
Distributions of endometrial NK cells, B cells, T cells, and Th2/Tc2 cells fail to predict pregnancy outcome following recurrent abortionQ74312960
Deficiency of decidual IL-10 in first trimester missed abortion: a lack of correlation with the decidual immune cell profileQ74312978
Murine experimental abortion by IL-2 administration is caused by activation of cytotoxic T lymphocytes and placental apoptosisQ74483210
Shedding of syncytiotrophoblast microvilli into the maternal circulation in pre-eclamptic pregnanciesQ74731060
An innate view of human pregnancyQ77326117
Interleukin-12 secretion by peripheral blood mononuclear cells is decreased in normal pregnant subjects and increased in preeclamptic patientsQ77784716
Quantitative analysis of peripheral blood Th0, Th1, Th2 and the Th1:Th2 cell ratio during normal human pregnancy and preeclampsiaQ78197149
Suppression of interleukin-12 production by human monocytes after preincubation with lipopolysaccharideQ78225210
Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor alpha productionQ24679477
Placental debris, oxidative stress and pre-eclampsiaQ34032003
Pregnancy: success and failure within the Th1/Th2/Th3 paradigmQ34299222
Signaling from cytokine receptors that affect TH1 responsesQ34625708
The Shwartzman reaction: a review including clinical manifestations and proposal for a univisceral or single organ third typeQ34716303
Interleukin 12, interferon gamma, and tumor necrosis factor alpha are the key cytokines of the generalized Shwartzman reactionQ36363647
Epidemiology of infection in pregnancyQ38919013
Evaluation of interleukin concentrations in amniotic fluid in preterm and term parturition and in oligohydramnios.Q39578454
Maternal and fetal immune responses during pregnancy.Q40785409
Preeclampsia: an excessive maternal inflammatory response to pregnancyQ40824430
Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon?Q40841827
Cell-associated IL-8 in human blood monocytes: analysis by flow cytometryQ41178400
Cytokines acting on or secreted by macrophages during intracellular infection (IL-10, IL-12, IFN-gamma).Q41353051
Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populationsQ41840721
The detection of intracytoplasmic interleukin-1 alpha, interleukin-1 beta and tumour necrosis factor alpha expression in human monocytes using two colour immunofluorescence flow cytometryQ43652986
Flow cytometric measurement of intracellular Th1 and Th2 cytokine production by human villous and extravillous cytotrophoblastQ43664274
Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies.Q44729936
Characterization of type 1 and type 2 cytokine production profile in physiologic and pathologic human pregnancy.Q50999795
Up-regulation of IL-12 in monocytes: a fundamental defect in common variable immunodeficiency.Q52030305
Lymphocyte subsets and mitogen stimulation of blood lymphocytes in normal pregnancy.Q52049233
Normal pregnancy and preeclampsia both produce inflammatory changes in peripheral blood leukocytes akin to those of sepsis.Q52237839
Proinflammatory cytokines (IL-17, IL-6, IL-18 and IL-12) and Th cytokines (IFN-gamma, IL-4, IL-10 and IL-13) in patients with allergic asthmaQ59314327
Elevations of serum interleukin-12 concentrations in women with severe pre-eclampsia HELLP syndromeQ59651257
Study on nonspecific immunity in pregnant women: increased chemiluminescence response of peripheral blood phagocytesQ68528906
Monocytosis and monocytic infiltration of decidua in early pregnancyQ68812830
Cytotoxic activity and phenotypic analysis of natural killer cells in early normal human pregnancyQ69476233
Tumour necrosis factor-alpha (TNF-alpha) gene polymorphism and expression in pre-eclampsiaQ71006388
P433issue3
P921main subjectflow cytometryQ1141429
P304page(s)490-497
P577publication date2003-03-01
P1433published inClinical and Experimental ImmunologyQ15716708
P1476titleMonocytes are primed to produce the Th1 type cytokine IL-12 in normal human pregnancy: an intracellular flow cytometric analysis of peripheral blood mononuclear cells
P478volume131

Reverse relations

cites work (P2860)
Q37416963A role for mannose-binding lectin, a component of the innate immune system in pre-eclampsia
Q57813347ART implantation failure and miscarriage in patients with elevated intracellular cytokine ratios: response to immune support therapy
Q36476871Amniotic mesenchymal cells from pre-eclamptic placentae maintain immunomodulatory features as healthy controls.
Q39781708Asthma during pregnancy alters immune cell profile and airway epithelial chemokine release.
Q36676660CXCL10/IP-10: a missing link between inflammation and anti-angiogenesis in preeclampsia?
Q52981622Changes in systemic type 1 and type 2 immunity in normal pregnancy and pre-eclampsia may be mediated by natural killer cells.
Q45922336Characterizing the pregnancy immune phenotype: results of the viral immunity and pregnancy (VIP) study.
Q36034464Does nitric oxide play a role in maternal tolerance towards the foetus?
Q34407590Enhanced natural killer-cell and T-cell responses to influenza A virus during pregnancy.
Q34139940Fragment Bb: evidence for activation of the alternative pathway of the complement system in pregnant women with acute pyelonephritis
Q91925385Giants in Obstetrics and Gynecology Series: a profile of Christopher Redman, MB, BChir, MRCP, FRCP
Q90740831Human labour is associated with altered regulatory T cell function and maternal immune activation
Q73047089Innately moving away from the Th1/Th2 paradigm in pregnancy
Q26743416Maternal monocytes in pregnancy and preeclampsia in humans and in rats
Q36569720Maternal serum soluble CD30 is increased in pregnancies complicated with acute pyelonephritis
Q33820908Monocytes and macrophages in pregnancy and pre-eclampsia
Q42495182Myeloperoxidase accumulates at the neutrophil surface and enhances cell metabolism and oxidant release during pregnancy
Q33813452PERIPHERAL PARASITAEMIA AND ITS ASSOCIATION WITH PLASMA CYTOKINES LEVELS IN MALARIA-INFECTED PREGNANT WOMEN IN ABA, ABIA STATE, NIGERIA
Q34740303Parity and placental infection affect antibody responses against Plasmodium falciparum during pregnancy
Q34235212Pentraxin 3 in amniotic fluid: a novel association with intra-amniotic infection and inflammation
Q36316857Pentraxin 3 in maternal circulation: an association with preterm labor and preterm PROM, but not with intra-amniotic infection/inflammation
Q35126662Peripheral blood TIM-3 positive NK and CD8+ T cells throughout pregnancy: TIM-3/galectin-9 interaction and its possible role during pregnancy
Q61940998Potential role of the intestinal microbiota of the mother in neonatal immune education
Q81446389Pre-eclampsia
Q56827901Pregnancy, but not the allergic status, influences spontaneous and induced interleukin-1beta (IL-1beta), IL-6, IL-10 and IL-12 responses
Q37308691Protective adaptive immunity to Chlamydophila abortus infection and control of ovine enzootic abortion (OEA).
Q34219845Regulation of innate and adaptive immunity by the female sex hormones oestradiol and progesterone
Q36875755Role of placentally produced inflammatory and regulatory cytokines in pregnancy and the etiology of preeclampsia
Q37715713Stimulation of monocytes by placental microparticles involves toll-like receptors and nuclear factor kappa-light-chain-enhancer of activated B cells
Q34455637TH17 cells in human recurrent pregnancy loss and pre-eclampsia
Q36878453The Th1/Th2 paradigm: still important in pregnancy?
Q47646733The immunological problem of pregnancy: 50 years with the hope of progress. A tribute to Peter Medawar
Q33919724The immunomodulatory role of syncytiotrophoblast microvesicles.
Q35190881Trophoblast deportation and the maternal inflammatory response in pre-eclampsia
Q46508908Validation and comparison of luminex multiplex cytokine analysis kits with ELISA: determinations of a panel of nine cytokines in clinical sample culture supernatants
Q26801481Vitamin D and Inflammatory Cytokines in Healthy and Preeclamptic Pregnancies
Q81024110[Materno-foetal dialogue and human embryo implantation: some evolving concepts]

Search more.