Tolerability, pharmacokinetics, and pharmacodynamics of DX-9065a, a new synthetic potent anticoagulant and specific factor Xa inhibitor, in healthy male volunteers

scientific article published on 01 September 1999

Tolerability, pharmacokinetics, and pharmacodynamics of DX-9065a, a new synthetic potent anticoagulant and specific factor Xa inhibitor, in healthy male volunteers is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0009-9236(99)70033-0
P698PubMed publication ID10511061

P2093author name stringTanaka M
Ikeda Y
Murayama N
Fujita M
Inoue T
Yamada H
Terada Y
Kunitada S
P2860cites workReduction in fatal pulmonary embolism and venous thrombosis by perioperative administration of subcutaneous heparin. Overview of results of randomized trials in general, orthopedic, and urologic surgeryQ39638109
Proposed cation-pi mediated binding by factor Xa: a novel enzymatic mechanism for molecular recognition.Q40467984
Pharmacokinetic optimisation of the treatment of deep vein thrombosisQ40905445
The kinetics of heparinQ45182386
Dibasic (Amidinoaryl)propanoic Acid Derivatives as Novel Blood Coagulation Factor Xa InhibitorsQ57310719
Prophylaxis of venous thromboembolism: analysis of cost effectivenessQ71496485
Radioimmunoassay method for DX-9065a, an anticoagulant agent. Development, evaluation and application to human plasmaQ71699308
Guide to anticoagulant therapy. Part 2: Oral anticoagulants. American Heart AssociationQ72285059
A novel factor Xa inhibitor: structure-activity relationships and selectivity between factor Xa and thrombinQ72673525
High-performance liquid chromatographic method for determination of DX-9065a, a novel anticoagulant, in human urine and feces using cation-exchange solid-phase extractionQ73428173
Crystal structures of factor Xa specific inhibitors in complex with trypsin: structural grounds for inhibition of factor Xa and selectivity against thrombinQ27729322
X-ray structure of active site-inhibited clotting factor Xa. Implications for drug design and substrate recognitionQ27734011
P433issue3
P921main subjectpharmacodynamicsQ725307
anticoagulantQ215118
pharmacokineticsQ323936
P304page(s)258-264
P577publication date1999-09-01
P1433published inClinical Pharmacology & TherapeuticsQ1101529
P1476titleTolerability, pharmacokinetics, and pharmacodynamics of DX-9065a, a new synthetic potent anticoagulant and specific factor Xa inhibitor, in healthy male volunteers
P478volume66

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cites work (P2860)
Q34189338Anticoagulants and inhibitors of platelet aggregation derived from leeches.
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Q44228251Development and validation of a liquid chromatography-mass spectrometric method for the determination of DPC 423, an antithrombotic agent, in rat and dog plasma
Q30924299Discovery of 3-amino-4-chlorophenyl P1 as a novel and potent benzamidine mimic via solid-phase synthesis of an isoxazoline library
Q28477868Evaluation of the efficacy and safety of rivaroxaban using a computer model for blood coagulation
Q36042279New anticoagulants: beyond heparin, low-molecular-weight heparin and warfarin
Q35752611New antithrombotic drugs: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
Q34027530Novel inhibitors of factor X for use in cardiovascular diseases
Q47583481Pharmacokinetics of YM466, a new factor Xa inhibitor, in rats and dogs.
Q93935767Pharmacokinetics of the anticoagulant 14C-DX-9065a in the healthy male volunteer after a single intravenous dose
Q35160253Selective factor Xa inhibition improves efficacy of venous thromboembolism prophylaxis in orthopedic surgery
Q36520745The status of new anticoagulants

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