Effects of ammonia on the anaplerotic pathway and amino acid metabolism in the brain: an ex vivo 13C NMR spectroscopic study of rats after administering [2-13C]] glucose with or without ammonium acetate

scientific article published on 01 September 1999

Effects of ammonia on the anaplerotic pathway and amino acid metabolism in the brain: an ex vivo 13C NMR spectroscopic study of rats after administering [2-13C]] glucose with or without ammonium acetate is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S0006-8993(99)01772-2
P698PubMed publication ID10546983

P2093author name stringY Tsukada
T Kanamatsu
P2860cites workMRS study of glutamate metabolism in cultured neurons/gliaQ48925402
Altered glutamine metabolism in rat portal drained viscera and hindquarter during hyperammonemiaQ67513982
Rapid analysis of amino acids using pre-column derivatizationQ70413233
Glutamine from glial cells is essential for the maintenance of the nerve terminal pool of glutamate: immunogold evidence from hippocampal slice culturesQ71894837
Selective Inhibition of the Tricarboxylic Acid Cycle of GABAergic Neurons with 3‐Nitropropionic Acid In VivoQ71978455
Glial-neuronal interactions as studied by cerebral metabolism of [2-13C]acetate and [1-13C]glucose: an ex vivo 13C NMR spectroscopic studyQ72261252
Glutamine and Glucose as Precursors of Transmitter Amino Acids: Ex Vivo StudiesQ72546448
[1-13C]glucose metabolism in rat cerebellar granule cells and astrocytes in primary culture. Evaluation of flux parameters by 13C- and 1H-NMR spectroscopyQ72655835
Fine structural localization of glutamine synthetase in astrocytes of rat brainQ28565591
The dynamics of ammonia metabolism in man. Effects of liver disease and hyperammonemiaQ34205897
In vivo 13C NMR measurements of cerebral glutamine synthesis as evidence for glutamate-glutamine cyclingQ36055611
Glutamine Synthetase: Glial Localization in BrainQ39138188
Biochemistry and physiology of brain ammoniaQ39462070
Utilization of glutamine and of TCA cycle constituents as precursors for transmitter glutamate and GABA.Q40559826
Pyruvate carboxylase: an astrocyte-specific enzyme implicated in the replenishment of amino acid neurotransmitter poolsQ41485422
Neuronal-glial metabolism under depolarizing conditions. A 13C-n.m.r. studyQ41830583
The acute action of ammonia on rat brain metabolism in vivoQ41992218
Cerebral metabolism of acetate and glucose studied by 13C-n.m.r. spectroscopy. A technique for investigating metabolic compartmentation in the brainQ42793650
In vivo activity of glutaminase in the brain of hyperammonaemic rats measured by 15N nuclear magnetic resonanceQ42823918
Post mortem changes in the content and specific radioactivity of several amino acids in four areas of the rat brainQ44262238
Severity of hyperammonemic encephalopathy correlates with brain ammonia level and saturation of glutamine synthetase in vivo.Q45293054
Importance of glutamine for gamma-aminobutyric acid synthesis in rat neostriatum in vivoQ45632648
Measurement of amino acid metabolism derived from [1-13C]glucose in the rat brain using 13C magnetic resonance spectroscopyQ48130113
Glutamine as precursor for the GABA and glutamate trasmitter poolsQ48146994
Glutamine--a major substrate for nerve endingsQ48185297
Cerebral metabolic compartmentation as revealed by nuclear magnetic resonance analysis of D-[1-13C]glucose metabolismQ48251252
Cerebral metabolism of [1,2-13C2]glucose and [U-13C4]3-hydroxybutyrate in rat brain as detected by 13C NMR spectroscopyQ48262311
Direct demonstration by [13C]NMR spectroscopy that glutamine from astrocytes is a precursor for GABA synthesis in neuronsQ48387362
Natural-abundance 13C NMR of brainQ48484969
Ammonia intoxication: effects on cerebral cortex and spinal cordQ48505332
The relative significance of CO2-fixing enzymes in the metabolism of rat brainQ48562259
Alteration of Striatal Glutamate Release After Glutamine Synthetase InhibitionQ48609922
The entry of [1-13C]glucose into biochemical pathways reveals a complex compartmentation and metabolite trafficking between glia and neurons: a study by 13C-NMR spectroscopyQ48636684
Pyruvate carboxylase activity in primary cultures of astrocytes and neuronsQ48719469
In Vivo Release from Cerebral Cortex of [14C]Glutamate Synthesized from [U-14C]GlutamineQ48756353
Portacaval anastomosis results in altered neuron--astrocytic metabolic trafficking of amino acids: evidence from 13C-NMR studies.Q48909788
The rate of turnover of cortical GABA from [1-13C]glucose is reduced in rats treated with the GABA-transaminase inhibitor vigabatrin (gamma-vinyl GABA).Q48925359
P433issue1-2
P921main subjectammoniaQ4087
P304page(s)11-19
P577publication date1999-09-01
P1433published inBrain ResearchQ4955782
P1476titleEffects of ammonia on the anaplerotic pathway and amino acid metabolism in the brain: an ex vivo 13C NMR spectroscopic study of rats after administering [2-13C]] glucose with or without ammonium acetate
P478volume841

Reverse relations

cites work (P2860)
Q48417498Anaplerosis for Glutamate Synthesis in the Neonate and in Adulthood.
Q30653214Assessment of a 1H high-resolution magic angle spinning NMR spectroscopy procedure for free sugars quantification in intact plant tissue.
Q38184420Cerebral effects of ammonia in liver disease: current hypotheses
Q48193936Detoxification of ammonia in mouse cortical GABAergic cell cultures increases neuronal oxidative metabolism and reveals an emerging role for release of glucose-derived alanine
Q46219792Direct measurement of backflux between oxaloacetate and fumarate following pyruvate carboxylation.
Q36946717Energy metabolism in brain cells: effects of elevated ammonia concentrations
Q36344825Faster flux of neurotransmitter glutamate during seizure - Evidence from 13C-enrichment of extracellular glutamate in kainate rat model
Q43794066Glutamine is the major precursor for GABA synthesis in rat neocortex in vivo following acute GABA-transaminase inhibition
Q61445634Insufficient glutamine synthetase activity during synaptogenesis causes spatial memory impairment in adult mice
Q97595755Long-term effects of medical management on growth and weight in individuals with urea cycle disorders
Q34370999Measurements of the anaplerotic rate in the human cerebral cortex using 13C magnetic resonance spectroscopy and [1-13C] and [2-13C] glucose
Q38861352Multifactorial Effects on Different Types of Brain Cells Contribute to Ammonia Toxicity
Q33476720Ornithine transcarbamylase deficiency with persistent abnormality in cerebral glutamate metabolism in adults
Q34464744Pyruvate carboxylation in neurons
Q24632909Structure, mechanism and regulation of pyruvate carboxylase
Q30650337Studies of metabolic compartmentation and glucose transport using in vivo MRS.
Q31126527The anaplerotic flux and ammonia detoxification in hepatic encephalopathy
Q30618244The role of astrocytes in CNS tumors: pre-clinical models and novel imaging approaches
Q26851324The role of glutamine synthetase and glutamate dehydrogenase in cerebral ammonia homeostasis

Search more.