Age-related variations in the neuroendocrine control, more than impaired receptor sensitivity, cause the reduction in the GH-releasing activity of GHRPs in human aging

scientific article published on 01 April 1998

Age-related variations in the neuroendocrine control, more than impaired receptor sensitivity, cause the reduction in the GH-releasing activity of GHRPs in human aging is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1013336238
P356DOI10.1023/A:1009970909015
P698PubMed publication ID11081183

P50authorGian Paolo CedaQ39885610
P2093author name stringR Deghenghi
E Ghigo
E Arvat
L Di Vito
L Gianotti
F Broglio
J Ramunni
P2860cites workA receptor in pituitary and hypothalamus that functions in growth hormone releaseQ24308321
Effect of growth hormone (GH)-releasing hormone (GHRH), atropine, pyridostigmine, or hypoglycemia on GHRP-6-induced GH secretion in manQ28265325
Pituitary adenylate cyclase activating polypeptide, growth hormone (GH)-releasing peptide and GH-releasing hormone stimulate GH release through distinct pituitary receptorsQ30311337
Neuroendocrine responses to a novel growth hormone secretagogue, L-692,429, in healthy older subjectsQ30465795
Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretogogue (MK-677) in healthy elderly subjectsQ30469767
Identification of a new G-protein-linked receptor for growth hormone secretagoguesQ34400323
Endogenous growth hormone (GH)-releasing hormone is required for GH responses to pharmacological stimuliQ37352016
Human growth hormone and human agingQ40906146
Human aging and the GH-IGF-I axis.Q41184176
Growth hormone (GH)-releasing peptide stimulates GH release in normal men and acts synergistically with GH-releasing hormoneQ41193598
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Arginine reinstates the somatotrope responsiveness to intermittent growth hormone-releasing hormone administration in normal adultsQ41903162
Central effects of growth hormone-releasing hexapeptide (GHRP-6) on growth hormone release are inhibited by central somatostatin actionQ42485430
Arginine and growth hormone-releasing hormone restore the blunted growth hormone-releasing activity of hexarelin in elderly subjects.Q42493112
Diminished pituitary responsiveness to growth hormone-releasing factor in aging male ratsQ42508292
Growth hormone (GH)-releasing hormone-(1-29) twice daily reverses the decreased GH and insulin-like growth factor-I levels in old menQ44014137
alpha-Glycerylphosphorylcholine administration increases the GH responses to GHRH of young and elderly subjectsQ44503563
Binding of a growth hormone releasing hexapeptide to specific hypothalamic and pituitary binding sitesQ44678987
On the actions of the growth hormone-releasing hexapeptide, GHRP.Q48749637
Central actions of peptide and non-peptide growth hormone secretagogues in the ratQ59649487
Arginine enhances the growth hormone-releasing activity of a synthetic hexapeptide (GHRP-6) in elderly but not in young subjects after oral administrationQ60674355
Age-related changes in growth hormone releasing factor and somatostatin in the rat hypothalamus.Q64935631
Restoration of normal growth hormone responsiveness to GHRH in normal aged men by infusion of low amounts of theophyllineQ67970716
Growth hormone (GH) responsiveness to combined administration of arginine and GH-releasing hormone does not vary with age in manQ68586058
Nyctohemeral growth hormone profiles in young and aged men: correlation with somatomedin-C levelsQ68963637
Reduced growth hormone releasing factor (GHRF)-like immunoreactivity and GHRF gene expression in the hypothalamus of aged ratsQ69232824
The influence of age on the 24-hour integrated concentration of growth hormone in normal individualsQ70061030
Small peptides as potent releasers of growth hormoneQ71568870
Mechanism of action of hexarelin and GHRP-6: analysis of the involvement of GHRH and somatostatin in the ratQ72193892
Modulation of growth hormone-releasing activity of hexarelin in manQ72193896
Effects of CNS active drugs and somatostatin antiserum on growth hormone release in young and old male ratsQ72490112
Blocked growth hormone-releasing peptide (GHRP-6)-induced GH secretion and absence of the synergic action of GHRP-6 plus GH-releasing hormone in patients with hypothalamopituitary disconnection: evidence that GHRP-6 main action is exerted at the hypQ72614776
Growth hormone (GH)-releasing hormone secretion is stimulated by a new GH-releasing hexapeptide in sheepQ72689426
Growth hormone-releasing activity of growth hormone-releasing peptide-6 is maintained after short-term oral pretreatment with the hexapeptide in normal agingQ72784282
GH releasing peptides--structure and kineticsQ72929119
P433issue1
P304page(s)51-58
P577publication date1998-04-01
P1433published inPituitaryQ26842250
P1476titleAge-related variations in the neuroendocrine control, more than impaired receptor sensitivity, cause the reduction in the GH-releasing activity of GHRPs in human aging
P478volume1