An essential role of interleukin-1beta in mediating NF-kappaB activity and COX-2 transcription in cells of the blood-brain barrier in response to a systemic and localized inflammation but not during endotoxemia

scientific article published on 01 December 1999

An essential role of interleukin-1beta in mediating NF-kappaB activity and COX-2 transcription in cells of the blood-brain barrier in response to a systemic and localized inflammation but not during endotoxemia is …
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scholarly articleQ13442814

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P356DOI10.1523/JNEUROSCI.19-24-10923.1999
P932PMC publication ID6784955
P698PubMed publication ID10594073

P2093author name stringS Rivest
N Laflamme
S Lacroix
P2860cites workCharacterization of tumor necrosis factor-deficient miceQ28512785
NF-kappa B: ten years afterQ29618566
Brain endothelial cells express cyclooxygenase-2 during lipopolysaccharide-induced fever: light and electron microscopic immunocytochemical studies.Q32041354
Pro-inflammatory signaling: last pieces in the NF-kappaB puzzle?Q33368441
Endothelial cells of the rat brain vasculature express cyclooxygenase-2 mRNA in response to systemic interleukin-1 beta: a possible site of prostaglandin synthesis responsible for feverQ34404722
Bacterial toxin-induced cytokine production studied at the single-cell levelQ35732477
Basal expression of cyclooxygenase-2 and nuclear factor-interleukin 6 are dominant and coordinately regulated by interleukin 1 in the pancreatic isletQ35890985
Production of mice deficient in genes for interleukin (IL)-1alpha, IL-1beta, IL-1alpha/beta, and IL-1 receptor antagonist shows that IL-1beta is crucial in turpentine-induced fever development and glucocorticoid secretionQ36400734
Induction of inhibitory factor kappaBalpha mRNA in the central nervous system after peripheral lipopolysaccharide administration: an in situ hybridization histochemistry study in the ratQ36603949
Cloning two isoforms of rat cyclooxygenase: differential regulation of their expressionQ36759109
Involvement of nuclear factor kappa B in the regulation of cyclooxygenase-2 expression by interleukin-1 in rheumatoid synoviocytesQ38348859
Hypoxia induces cyclooxygenase-2 via the NF-kappaB p65 transcription factor in human vascular endothelial cellsQ38349479
Mechanisms of CNS response to systemic immune challenge: the febrile responseQ40643699
Resistance to fever induction and impaired acute-phase response in interleukin-1 beta-deficient miceQ40682982
The inflammatory response in interleukin-1 beta-deficient mice: comparison with other cytokine-related knock-out mice.Q40977485
A novel gene iba1 in the major histocompatibility complex class III region encoding an EF hand protein expressed in a monocytic lineageQ41183035
Cyclooxygenase 2 mRNA expression in rat brain after peripheral injection of lipopolysaccharide.Q42461540
Effects of systemic immunogenic insults and circulating proinflammatory cytokines on the transcription of the inhibitory factor kappaB alpha within specific cellular populations of the rat brainQ48175000
Electron microscopic evidence for induction of cyclooxygenase-2 in brain endothelial cellsQ48300436
Lipopolysaccharide injected into the cerebral ventricle evokes fever through induction of cyclooxygenase-2 in brain endothelial cells.Q48310673
Effect of acute systemic inflammatory response and cytokines on the transcription of the genes encoding cyclooxygenase enzymes (COX-1 and COX-2) in the rat brainQ48547269
Intravenous lipopolysaccharide induces cyclooxygenase 2-like immunoreactivity in rat brain perivascular microglia and meningeal macrophagesQ48708462
Lipopolysaccharide stimulates the tyrosine phosphorylation of mitogen-activated protein kinases p44, p42, and p41 in vascular endothelial cells in a soluble CD14-dependent manner. Role of protein tyrosine phosphorylation in lipopolysaccharide-induceQ71746873
Transcriptional role of the nuclear factor kappa B site in the induction by lipopolysaccharide and suppression by dexamethasone of cyclooxygenase-2 in U937 cellsQ74353033
P433issue24
P921main subjectendotoxemiaQ5832599
blood–brain barrierQ221694
NF-κBQ411114
P304page(s)10923-10930
P577publication date1999-12-01
P1433published inJournal of NeuroscienceQ1709864
P1476titleAn essential role of interleukin-1beta in mediating NF-kappaB activity and COX-2 transcription in cells of the blood-brain barrier in response to a systemic and localized inflammation but not during endotoxemia
P478volume19

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