Muscarinic M1 receptor agonists increase the secretion of the amyloid precursor protein ectodomain

scientific article published on 01 January 1997

Muscarinic M1 receptor agonists increase the secretion of the amyloid precursor protein ectodomain is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S0024-3205(97)00038-6
P698PubMed publication ID9121365

P50authorSteven A. FarberQ54305358
P2093author name stringR M Nitsch
D M Müller
K Mendla
P2860cites workCorrelative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic MiceQ22242267
Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor proteinQ22251280
Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptorsQ24294213
RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's diseaseQ24314906
beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activityQ28593175
Serotonin 5-HT2a and 5-HT2c receptors stimulate amyloid precursor protein ectodomain secretionQ28609364
Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairmentQ29547294
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's diseaseQ29614374
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptorQ29618322
Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein productionQ34280406
WAL 2014--a muscarinic agonist with preferential neuron-stimulating propertiesQ34360995
Protection against HIV-1 gp120-induced brain damage by neuronal expression of human amyloid precursor proteinQ36364676
beta-Amyloid precursor protein metabolites and loss of neuronal Ca2+ homeostasis in Alzheimer's disease.Q40384274
Scavenger receptor-mediated adhesion of microglia to beta-amyloid fibrilsQ41173971
Muscarinic regulation of Alzheimer's disease amyloid precursor protein secretion and amyloid beta-protein production in human neuronal NT2N cellsQ41361359
Amyloid precursor protein secretion and beta A4 amyloid generation are not mutually exclusiveQ41450284
Hydrogen peroxide mediates amyloid beta protein toxicityQ41460857
Inhibition of beta-amyloid production by activation of protein kinase C.Q41511447
Production of the Alzheimer amyloid beta protein by normal proteolytic processingQ41599298
beta-Amyloid precursor protein isoforms show correlations with neurones but not with glia of demented subjectsQ48228293
The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowthQ48458288
Dysfunction of cholinergic and dopaminergic neuronal systems in beta-amyloid protein--infused rats.Q49087107
Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments.Q53180704
An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.Q53207278
Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.Q53209417
Regulated secretion of beta-amyloid precursor protein in rat brainQ71511604
Preparative methods for brain slices: a discussionQ71519225
Making the best of brain slices: comparing preparative methodsQ71519228
P433issue13-14
P407language of work or nameEnglishQ1860
P304page(s)985-991
P577publication date1997-01-01
P1433published inLife SciencesQ5256275
P1476titleMuscarinic M1 receptor agonists increase the secretion of the amyloid precursor protein ectodomain
P478volume60

Reverse relations

cites work (P2860)
Q406502936beta-acetoxy nortropane regulated processing of amyloid precursor protein in CHOm1 cells and rat brain
Q34147757AF150(S) and AF267B: M1 muscarinic agonists as innovative therapies for Alzheimer's disease
Q30388923Allosteric activators of muscarinic receptors as novel approaches for treatment of CNS disorders
Q36269317Basal forebrain cholinergic dysfunction in Alzheimer's disease--interrelationship with beta-amyloid, inflammation and neurotrophin signaling
Q34121565Beyond the cholinergic hypothesis: do current drugs work in Alzheimer's disease?
Q40909041Cholinergic Mechanisms in the Cerebral Cortex: Beyond Synaptic Transmission.
Q37130148Cholinergic and glutamatergic alterations beginning at the early stages of Alzheimer disease: participation of the phospholipase A2 enzyme
Q28287090Cholinergic treatments with emphasis on m1 muscarinic agonists as potential disease-modifying agents for Alzheimer's disease
Q64052629Constipation in Tg2576 mice model for Alzheimer's disease associated with dysregulation of mechanism involving the mAChR signaling pathway and ER stress response
Q35538840M<sub>1</sub> Muscarinic Agonists Can Modulate Some of the Hallmarks in Alzheimer's Disease: Implications in Future Therapy
Q38192962M1 muscarinic acetylcholine receptor in Alzheimer's disease
Q43651491Reduction of cerebrospinal fluid amyloid beta after systemic administration of M1 muscarinic agonists
Q43720996Reduction of cortical amyloid beta levels in guinea pig brain after systemic administration of physostigmine.
Q34061109Regulation of APP cleavage by alpha-, beta- and gamma-secretases
Q28570077Simultaneous changes in secretory amyloid precursor protein and β-amyloid peptide release from rat hippocampus by activation of muscarinic receptors
Q34039304Strategies to delay the onset of Alzheimer's disease.
Q44416619Synthesis and muscarinic activities of O-[(benzyl- or benzoyl-pyrazolyl)propynyl]-oximes of N-methylpiperidinone, 3-tropinone, and 3-quinuclidinone.
Q36622649The significance of the cholinergic system in the brain during aging and in Alzheimer's disease
Q33756911Theoretical basis for the benefit of postmenopausal estrogen substitution
Q52590407Therapeutic potential of multifunctional tacrine analogues.
Q34262792Treatment of Alzheimer's disease with cholinesterase inhibitors

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