Rapid engineering of polyketide overproduction by gene transfer to industrially optimized strains

scientific article published on April 16, 2003

Rapid engineering of polyketide overproduction by gene transfer to industrially optimized strains is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S10295-003-0045-1
P953full work available at URLhttp://link.springer.com/article/10.1007/s10295-003-0045-1/fulltext.html
http://link.springer.com/content/pdf/10.1007/s10295-003-0045-1
http://link.springer.com/content/pdf/10.1007/s10295-003-0045-1.pdf
P698PubMed publication ID12698320

P2093author name stringC. Richard Hutchinson
Robert McDaniel
Eduardo Rodriguez
Zhihao Hu
Sally Ou
Yanina Volchegursky
P2860cites workAlteration of the substrate specificity of a modular polyketide synthase acyltransferase domain through site-specific mutations.Q30329267
Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products.Q30650504
A multiplasmid approach to preparing large libraries of polyketidesQ30789676
Genome shuffling leads to rapid phenotypic improvement in bacteriaQ30809181
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Acyltransferase domain substitutions in erythromycin polyketide synthase yield novel erythromycin derivativesQ39847577
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Engineered biosynthesis of novel polyketidesQ42286784
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Modular organization of genes required for complex polyketide biosynthesisQ42627871
A new substrate specificity for acyl transferase domains of the ascomycin polyketide synthase in Streptomyces hygroscopicus.Q43851405
Generation of multiple bioactive macrolides by hybrid modular polyketide synthases in Streptomyces venezuelaeQ43906569
Precursor-directed production of erythromycin analogs by Saccharopolyspora erythraeaQ46192855
An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraeaQ48248704
Construction of new vectors for high-level expression in actinomycetesQ48567139
High efficiency intergeneric conjugal transfer of plasmid DNA from Escherichia coli to methyl DNA-restricting streptomycetes.Q52527728
Manipulation of Modular Polyketide Synthases.Q53673885
Genetic engineering of an industrial strain of Saccharopolyspora erythraea for stable expression of the Vitreoscilla haemoglobin gene (vhb).Q54120504
The mRNA for the 23S rRNA methylase encoded by the ermE gene of Saccharopolyspora erythraea is translated in the absence of a conventional ribosome-binding site.Q54192770
Formation of functional heterologous complexes using subunits from the picromycin, erythromycin and oleandomycin polyketide synthasesQ73419416
Recombinant polyketide synthesis in Streptomyces: engineering of improved host strainsQ77812559
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectbiotechnologyQ7108
bioengineeringQ580689
gene deliveryQ2790163
Applied Microbiology and BiotechnologyQ13553694
P304page(s)480-488
P577publication date2003-04-16
P1433published inJournal of Industrial Microbiology & BiotechnologyQ1709847
P1476titleRapid engineering of polyketide overproduction by gene transfer to industrially optimized strains
P478volume30