Retigabine strongly reduces repetitive firing in rat entorhinal cortex

scientific article published on 01 December 1999

Retigabine strongly reduces repetitive firing in rat entorhinal cortex is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S0014-2999(99)00786-4
P698PubMed publication ID10618466

P2093author name stringU Heinemann
D Schmitz
C Rundfeldt
R Hetka
P2860cites workA pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy familyQ28115034
A potassium channel mutation in weaver mice implicates membrane excitability in granule cell differentiationQ28115658
Reduction of K+ uptake in glia prevents long-term depression maintenance and causes epileptiform activity.Q33789620
The new anticonvulsant retigabine (D-23129) acts as an opener of K+ channels in neuronal cellsQ34447899
The inward rectifier potassium channel family.Q36684014
Evaluation of antiepileptic drug efficacy. A review of clinical trial designQ40395695
Entorhinal-hippocampal connections: a speculative view of their functionQ40485288
Strategies in antiepileptic drug development: is rational drug design superior to random screening and structural variation?Q40758069
Identification and preclinical testing of novel antiepileptic compoundsQ40908835
Ca(2+)-activated K+ currents in neurones: types, physiological roles and modulationQ41003282
D-23129: a potent anticonvulsant in the amygdala kindling model of complex partial seizuresQ42638756
Cells of origin of entorhinal cortical afferents to the hippocampus and fascia dentata of the ratQ45127850
Synaptic and intrinsic properties of neurons of origin of the perforant path in layer II of the rat entorhinal cortex in vitroQ48118710
Differential electroresponsiveness of stellate and pyramidal-like cells of medial entorhinal cortex layer II.Q48253335
Epileptiform activity induced by lowering extracellular [Mg2+] in combined hippocampal-entorhinal cortex slices: modulation by receptors for norepinephrine and N-methyl-D-aspartateQ48256110
Effects of retigabine (D-23129) on different patterns of epileptiform activity induced by 4-aminopyridine in rat entorhinal cortex hippocampal slicesQ48290379
Epileptiform activity in combined slices of the hippocampus, subiculum and entorhinal cortex during perfusion with low magnesium mediumQ48309204
Valproate selectively reduces the persistent fraction of Na+ current in neocortical neuronsQ48381336
Morphological and electrophysiological characterization of layer III cells of the medial entorhinal cortex of the rat.Q48756915
Late low magnesium-induced epileptiform activity in rat entorhinal cortex slices becomes insensitive to the anticonvulsant valproic acidQ48875966
Properties of a delayed rectifier potassium current in dentate granule cells isolated from the hippocampus of patients with chronic temporal lobe epilepsyQ48934134
The effects of D-23129, a new experimental anticonvulsant drug, on neurotransmitter amino acids in the rat hippocampus in vitro.Q51589015
D-23129: a new anticonvulsant with a broad spectrum activity in animal models of epileptic seizures.Q53989493
Paroxysmal epileptiform discharges in temporal lobe slices after prolonged exposure to low magnesium are resistant to clinically used anticonvulsantsQ56971339
Regional and time dependent variations of low Mg2+ induced epileptiform activity in rat temporal cortex slicesQ56971348
Synaptic and intrinsic responses of medical entorhinal cortical cells in normal and magnesium-free medium in vitroQ69919825
Anticonvulsant properties of D-20443 in genetically epilepsy-prone rats: prediction of clinical responseQ71526090
The effects of anticonvulsant agents on 4-aminopyridine induced epileptiform activity in rat hippocampus in vitroQ72237354
Preferential neuronal loss in layer III of the entorhinal cortex in patients with temporal lobe epilepsyQ72270730
Characterization of the K+ channel opening effect of the anticonvulsant retigabine in PC12 cellsQ77893179
P433issue2-3
P407language of work or nameEnglishQ1860
P921main subjectentorhinal cortexQ2603645
P304page(s)165-171
P577publication date1999-12-01
P1433published inEuropean Journal of PharmacologyQ1376712
P1476titleRetigabine strongly reduces repetitive firing in rat entorhinal cortex
P478volume386

Reverse relations

cites work (P2860)
Q35717049Clinical utility of adjunctive retigabine in partial onset seizures in adults.
Q36534135Contribution of near-threshold currents to intrinsic oscillatory activity in rat medial entorhinal cortex layer II stellate cells
Q35326586Contributions of Kv7-mediated potassium current to sub- and suprathreshold responses of rat layer II/III neocortical pyramidal neurons.
Q46857416Effects of retigabine on the neurodegeneration and extracellular glutamate changes induced by 4-aminopyridine in rat hippocampus in vivo
Q41942478Efficacy of Retigabine on Acute Limbic Seizures in Adult Rats
Q43071251Enhancing m currents: a way out for neuropathic pain?
Q42458970Expression and functional roles of Kv7/KCNQ/M-channels in rat medial entorhinal cortex layer II stellate cells
Q46387953Isobolographic characterization of interactions of retigabine with carbamazepine, lamotrigine, and valproate in the mouse maximal electroshock-induced seizure model.
Q44737230M channels containing KCNQ2 subunits modulate norepinephrine, aspartate, and GABA release from hippocampal nerve terminals.
Q44280661Neuroprotective effects of anticonvulsants in rat hippocampal slice cultures exposed to oxygen/glucose deprivation
Q37950518Novel medications for epilepsy
Q35102221Oxidative modification of M-type K(+) channels as a mechanism of cytoprotective neuronal silencing
Q43515162Progress report on new antiepileptic drugs: a summary of the Fifth Eilat Conference (EILAT V).
Q47848016Retigabine calms seizure-induced behavior following status epilepticus
Q34415600Retigabine: chemical synthesis to clinical application.
Q34541901Retigabine: in partial seizures
Q37761269Retigabine: the newer potential antiepileptic drug.
Q36675813The new KCNQ2 activator 4-Chlor-N-(6-chlor-pyridin-3-yl)-benzamid displays anticonvulsant potential.
Q28138343The novel anticonvulsant retigabine activates M-currents in Chinese hamster ovary-cells tranfected with human KCNQ2/3 subunits

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