The thrombin receptor in adrenal medullary microvascular endothelial cells is negatively coupled to adenylyl cyclase through a Gi protein

scientific article published on 01 May 1997

The thrombin receptor in adrenal medullary microvascular endothelial cells is negatively coupled to adenylyl cyclase through a Gi protein is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0167-4889(97)00002-5
P698PubMed publication ID9194575

P2093author name stringJ W Fenton
P I Lelkes
V G Manolopoulos
P2860cites workMolecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activationQ24337851
The proteinase activated receptor-2 (PAR-2) mediates mitogenic responses in human vascular endothelial cellsQ24562218
Molecular cloning of a potential proteinase activated receptorQ24563694
Inhibition of adenylyl cyclase by Gi alphaQ28646204
Transmembrane Receptors and Intracellular Pathways that Control Cell ProliferationQ35227036
Pharmacology of Protein Kinase InhibitorsQ36213534
Role of Ca2+ and cyclic AMP in the regulation of the production of prostacyclin by the vascular endotheliumQ36277915
Activation of a Cl- current by hypotonic volume increase in human endothelial cellsQ36415647
'Crosstalk': a pivotal role for protein kinase C in modulating relationships between signal transduction pathwaysQ37158511
Sustained activation of protein kinase C is essential to HL-60 cell differentiation to macrophageQ37640157
Post-translational and activation-dependent modifications of the G protein-coupled thrombin receptor.Q38296686
Thrombin-induced prostacyclin biosynthesis in human endothelium: role of guanine nucleotide regulatory proteins in stimulus/coupling responsesQ38516662
From epinephrine to cyclic AMP.Q39247573
Nobel Lecture. G proteins and regulation of adenylyl cyclaseQ40424775
Adenylyl cyclases and the interaction between calcium and cAMP signallingQ40496494
Thrombin-induced endothelial cell dysfunction.Q40558911
Regulation of endothelial cell cyclic nucleotide metabolism by prostacyclinQ40682963
Synthetic low-molecular weight thrombin inhibitors: molecular design and pharmacological profileQ40808683
Gating by cyclic AMP: expanded role for an old signaling pathwayQ40944555
Complexity and diversity of mammalian adenylyl cyclasesQ41048221
Protease-mediated signalling: new paradigms for cell regulation and drug developmentQ41098006
G-protein-coupled receptors in normal human erythroid progenitor cellsQ41262078
Dual regulation of cyclic AMP formation by thrombin in HEL cells, a leukaemic cell line with megakaryocytic propertiesQ41651381
Protein kinase C and cyclic AMP modulate thrombin-induced platelet-activating factor synthesis in human endothelial cellsQ42078279
Regulation of the adenylyl cyclase signaling system in various types of cultured endothelial cellsQ42477782
Regulation of thrombin-induced endothelial cell activation by bacterial toxins.Q42500776
Modulation of adenylate cyclase of human platelets by phorbol ester. Impairment of the hormone-sensitive inhibitory pathwayQ42663468
Thrombin exerts a dual effect on stimulated adenylate cyclase in hamster fibroblasts, an inhibition via a GTP-binding protein and a potentiation via activation of protein kinase CQ42858784
Specific adhesion between pheochromocytoma (PC12) cells and adrenal medullary endothelial cells in co-cultureQ44529176
Functional implications of cAMP and Ca2+ on prostaglandin I2 and thromboxane A2 synthesis by human endothelial cellsQ67487335
Human alpha- to zeta-thrombin cleavage occurs with neutrophil cathepsin G or chymotrypsin while fibrinogen clotting activity is retainedQ68817200
Thrombin-induced increase in albumin permeability across the endotheliumQ69549420
Ni-mediated inhibition of human platelet adenylate cyclase by thrombinQ70506411
Structural domains of thrombin involved in the induction of mitogenesis in cultured human vascular smooth muscle cellsQ70903144
Proflavin binding within the fibrinopeptide groove adjacent to the catalytic site of human alpha-thrombinQ71348473
Opposing effects on modulation of angiogenesis by protein kinase C and cAMP-mediated pathwaysQ71632247
Initiation of proliferative events by human ?-thrombin requires both receptor binding and enzymic activityQ72411327
Mechanism of pertussis toxin action on the adenylate cyclase system. Inhibition of the turn-on reaction of the inhibitory regulatory siteQ72575392
Adenylyl cyclase isoforms are differentially expressed in primary cultures of endothelial cells and whole tissue homogenates from various rat tissuesQ72625088
G proteins in aortic endothelial cells and bradykinin-induced formation of nitric oxideQ72709441
Subtype-specific increase in G-protein alpha-subunit mRNA by interleukin 1 betaQ93512117
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectmicrovascular endothelial cellQ107137234
P304page(s)321-332
P577publication date1997-05-01
P1433published inBiochimica et Biophysica ActaQ864239
P1476titleThe thrombin receptor in adrenal medullary microvascular endothelial cells is negatively coupled to adenylyl cyclase through a Gi protein
P478volume1356

Reverse relations

cites work (P2860)
Q35544489Heterotrimeric G proteins, focal adhesion kinase, and endothelial barrier function
Q62661282Inhibition of angiogenesis by blockers of volume-regulated anion channels
Q43263886Proteinase-activated receptor-1 agonists attenuate nociception in response to noxious stimuli
Q45958192Real-time monitoring of cAMP levels in living endothelial cells: thrombin transiently inhibits adenylyl cyclase 6.

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