Novel function of lecithin-cholesterol acyltransferase. Hydrolysis of oxidized polar phospholipids generated during lipoprotein oxidation

scientific article published on 01 June 1997

Novel function of lecithin-cholesterol acyltransferase. Hydrolysis of oxidized polar phospholipids generated during lipoprotein oxidation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.272.26.16231
P698PubMed publication ID9195924

P2093author name stringM Liu
K Wang
P V Subbaiah
J Goyal
P2860cites workPlatelet-activating factor acetylhydrolase deficiency. A missense mutation near the active site of an anti-inflammatory phospholipaseQ24562119
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Plasma Platelet-activating Factor Acetylhydrolase Is a Secreted Phospholipase A2 with a Catalytic TriadQ28505897
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Anti-inflammatory properties of a platelet-activating factor acetylhydrolaseQ34307399
The role of lipid peroxidation and antioxidants in oxidative modification of LDL.Q35379559
Hydrolysis and transesterification of platelet-activating factor by lecithin-cholesterol acyltransferaseQ35548859
Modified low density lipoprotein and its constituents augment cytokine-activated vascular cell adhesion molecule-1 gene expression in human vascular endothelial cellsQ35553734
Characterization of serum platelet-activating factor (PAF) acetylhydrolase. Correlation between deficiency of serum PAF acetylhydrolase and respiratory symptoms in asthmatic childrenQ35594599
Oxidatively modified LDL contains phospholipids with platelet-activating factor-like activity and stimulates the growth of smooth muscle cellsQ35766281
Protective effect of high density lipoprotein associated paraoxonase. Inhibition of the biological activity of minimally oxidized low density lipoproteinQ35768830
Lysophosphatidylcholine, a component of atherogenic lipoproteins, induces mononuclear leukocyte adhesion molecules in cultured human and rabbit arterial endothelial cellsQ35822759
Characterization of the platelet-activating factor acetylhydrolase from human plasma by heterologous expression in Xenopus laevis oocytesQ35848282
Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipidsQ36263522
Lecithin-cholesterol acyltransferase in the metabolism of high-density lipoproteinsQ37296651
Effects of site-directed mutagenesis at residues cysteine-31 and cysteine-184 on lecithin-cholesterol acyltransferase activityQ37414301
LDL-induced cytotoxicity and its inhibition by HDL in human vascular smooth muscle and endothelial cells in cultureQ40243249
Oxygen radicals inhibit human plasma acetylhydrolase, the enzyme that catabolizes platelet-activating factorQ40336954
HDL, its enzymes and its potential to influence lipid peroxidation.Q40475176
Pefabloc, 4-[2-aminoethyl]benzenesulfonyl fluoride, is a new, potent nontoxic and irreversible inhibitor of PAF-degrading acetylhydrolaseQ40949634
Mammalian platelet-activating factor acetylhydrolasesQ41005174
Phospholipid hydrolysis of mildly oxidized LDL reduces their cytotoxicity to cultured endothelial cells. Potential protective role against atherogenesisQ41335890
Roles of cysteines in human lecithin:cholesterol acyltransferaseQ41565116
High-density lipoprotein inhibits the oxidative modification of low-density lipoproteinQ41733901
Gas-phase cigarette smoke inhibits plasma lecithin-cholesterol acyltransferase activity by modification of the enzyme's free thiolsQ46065463
Analysis of the monocyte chemotactic response to lysophosphatidylcholine: role of lysophospholipase C.Q46132358
Chicken lecithin-cholesterol acyltransferase. Molecular characterization reveals unusual structure and expression patternQ48069326
Formation of platelet-activating factor-like phospholipids by Fe2+/ascorbate/EDTA-induced lipid peroxidationQ48330817
Copper-induced LDL peroxidation investigated by 1H-NMR spectroscopyQ57925460
Release of platelet-activating factor in systemic lupus erythematosusQ58831832
Platelet-activating factor formation during oxidative modification of low-density lipoprotein when PAF-acetylhydrolase has been inactivatedQ59394776
Release of fatty acids from phosphatidylcholine by lecithin-cholesterol acyltransferase.Q64949995
Altered positional specificity of human plasma lecithin-cholesterol acyltransferase in the presence of sn-2 arachidonoyl phosphatidyl cholines. Mechanism of formation of saturated cholesteryl estersQ67550112
'A'-esterases. Enzymes looking for a role?Q69947150
Oxidized LDL-induced leukocyte/endothelium interaction in vivo involves the receptor for platelet-activating factorQ70462627
Studies on phospholipase A inhibitor in blood plasma. I. Purification and characterization of phospholipase A inhibitor in bovine plasmaQ70675772
Activation of plasma lysolecithin acyltransferase reaction by apolipoproteins A-I, C-I and EQ70742578
Vertebrate class distribution of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetylhydrolase in serumQ71012170
Disparate effects of oxidation on plasma acyltransferase activities: inhibition of cholesterol esterification but stimulation of transesterification of oxidized phospholipidsQ71127852
Lipid peroxidation in low density lipoproteins from human plasma and egg yolk promotes accumulation of 1-acyl analogues of platelet-activating factor-like lipidsQ71913601
PAF-acether-degrading acetylhydrolase in plasma LDL is inactivated by copper- and cell-mediated oxidationQ72282272
Lysophosphatidylcholine in oxidized low-density lipoprotein increases endothelial susceptibility to polymorphonuclear leukocyte-induced endothelial dysfunction in porcine coronary arteries. Role of protein kinase CQ72314416
P433issue26
P407language of work or nameEnglishQ1860
P304page(s)16231-16239
P577publication date1997-06-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleNovel function of lecithin-cholesterol acyltransferase. Hydrolysis of oxidized polar phospholipids generated during lipoprotein oxidation
P478volume272

Reverse relations

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