Binding of an antibody mimetic of the human low density lipoprotein receptor to apolipoprotein E is governed through electrostatic forces. Studies using site-directed mutagenesis and molecular modeling

scientific article published on 01 March 2000

Binding of an antibody mimetic of the human low density lipoprotein receptor to apolipoprotein E is governed through electrostatic forces. Studies using site-directed mutagenesis and molecular modeling is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.275.10.7109
P698PubMed publication ID10702278

P50authorBernhard RuppQ42552417
P2093author name stringR Milne
K H Weisgraber
T L Innerarity
E Rassart
T Hirama
R MacKenzie
R Raffaï
P2860cites workA general method of in vitro preparation and specific mutagenesis of DNA fragments: study of protein and DNA interactionsQ24597783
Structure of a monoclonal 2E8 Fab antibody fragment specific for the low-density lipoprotein-receptor binding region of apolipoprotein E refined at 1.9 AQ27617668
Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein EQ27663468
Novel mechanism for defective receptor binding of apolipoprotein E2 in type III hyperlipoproteinemiaQ27733293
Molecular basis of familial hypercholesterolaemia from structure of LDL receptor moduleQ27742097
Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinityQ27756699
Interactions of protein antigens with antibodiesQ33594252
Anatomy of the antibody moleculeQ34060425
Electrostatic fields in antibodies and antibody/antigen complexesQ35748601
Identification of the low density lipoprotein receptor-binding site in apolipoprotein B100 and the modulation of its binding activity by the carboxyl terminus in familial defective apo-B100.Q37378785
Bacterial expression and purification of the Fab fragment of a monoclonal antibody specific for the low-density lipoprotein receptor-binding site of human apolipoprotein E.Q38324464
Folding, calcium binding, and structural characterization of a concatemer of the first and second ligand-binding modules of the low-density lipoprotein receptorQ47732365
LDL-receptor structure. Calcium cages, acid baths and recycling receptors.Q55067160
Rapid, electrostatically assisted association of proteinsQ71031198
P4510describes a project that usessite-directed mutagenesisQ2642668
P433issue10
P407language of work or nameEnglishQ1860
P304page(s)7109-7116
P577publication date2000-03-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleBinding of an antibody mimetic of the human low density lipoprotein receptor to apolipoprotein E is governed through electrostatic forces. Studies using site-directed mutagenesis and molecular modeling
P478volume275

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cites work (P2860)
Q27473104A functional epitope determinant on domain III of the Japanese encephalitis virus envelope protein interacted with neutralizing-antibody combining sites
Q38748440A randomized trial and novel SPR technique identifies altered lipoprotein-LDL receptor binding as a mechanism underlying elevated LDL-cholesterol in APOE4s
Q37596501Epitope determinants of a chimpanzee Fab antibody that efficiently cross-neutralizes dengue type 1 and type 2 viruses map to inside and in close proximity to fusion loop of the dengue type 2 virus envelope glycoprotein
Q35104620Human Plasma Very Low-Density Lipoproteins Are Stabilized by Electrostatic Interactions and Destabilized by Acidic pH
Q27486404Humanized Monoclonal Antibodies Derived from Chimpanzee Fabs Protect against Japanese Encephalitis Virus In Vitro and In Vivo
Q33201423Identification of chimpanzee Fab fragments by repertoire cloning and production of a full-length humanized immunoglobulin G1 antibody that is highly efficient for neutralization of dengue type 4 virus
Q31055400Model IgG monoclonal autoantibody-anti-idiotype pair for dissecting the humoral immune response to oxidized low density lipoprotein
Q27624926Structural models for carcinoembryonic antigen and its complex with the single-chain Fv antibody molecule MFE23
Q34464911Survey of the year 2000 commercial optical biosensor literature

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