Prevention of passively transferred experimental autoimmune myasthenia gravis by Fab fragments of monoclonal antibodies directed against the main immunogenic region of the acetylcholine receptor

scientific article published on 01 May 2000

Prevention of passively transferred experimental autoimmune myasthenia gravis by Fab fragments of monoclonal antibodies directed against the main immunogenic region of the acetylcholine receptor is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0165-5728(99)00259-3
P698PubMed publication ID10713351

P2093author name stringD Papanastasiou
S J Tzartos
K Poulas
A Kokla
P2860cites workEvidence against acetylcholine receptor having a main immunogenic region as target for autoantibodies in myasthenia gravisQ69091652
Epitopes on human acetylcholine receptor defined by monoclonal antibodies and myasthenia gravis seraQ69139840
29 Production and assay of antibodies to acetylcholine receptorsQ71049501
Characterisation, crystallisation and preliminary X-ray diffraction analysis of a Fab fragment of a rat monoclonal antibody with very high affinity for the human muscle acetylcholine receptorQ71426806
Demonstration of a main immunogenic region on acetylcholine receptors from human muscle using monoclonal antibodies to human receptorQ71763580
Pharmacokinetics and organ distribution of cationized colchicine-specific IgG and Fab fragments in ratQ77752302
Myasthenia gravisQ93537362
Localization of the main immunogenic region of human muscle acetylcholine receptor to residues 67-76 of the alpha subunitQ33568995
Gel filtration: a method for desalting and group separationQ34246481
A muscle acetylcholine receptor is expressed in the human cerebellar medulloblastoma cell line TE671.Q34460958
The potential for enhanced tumour localisation by poly(ethylene glycol) modification of anti-CEA antibodyQ36080676
Specificities of antibodies to acetylcholine receptors in sera from myasthenia gravis patients measured by monoclonal antibodiesQ36275255
Crystallization and preliminary crystallographic study of an Fab fragment of a pathogenic rat monoclonal antibody against the nicotinic acetylcholine receptor.Q36277683
Experimental autoimmune myasthenia: A model of myasthenia gravis in rats and guinea pigsQ36358130
Pathological mechanisms in experimental autoimmune myasthenia gravis. II. Passive transfer of experimental autoimmune myasthenia gravis in rats with anti-acetylcholine recepotr antibodiesQ36359851
Design of yeast-secreted albumin derivatives for human therapy: biological and antiviral properties of a serum albumin-CD4 genetic conjugateQ36868245
Passively transferred myasthenia gravis: protection of mouse endplates by Fab fragments from human myasthenic IgGQ37001311
Construction and characterization of a humanized single chain Fv antibody fragment against the main immunogenic region of the acetylcholine receptorQ38323531
High affinity single-chain Fv antibody fragments protecting the human nicotinic acetylcholine receptorQ38323537
Fab fragments of monoclonal antibodies protect the human acetylcholine receptor against antigenic modulation caused by myasthenic seraQ41759155
Radiolabeled fragments of monoclonal antibodies against carcinoembryonic antigen for localization of human colon carcinoma grafted into nude miceQ42936967
Prolonged circulation of recombinant human granulocyte-colony stimulating factor by covalent linkage to albumin through a heterobifunctional polyethylene glycolQ46157342
Myasthenia gravis induced by monoclonal antibodies to acetylcholine receptorsQ46803307
Anatomy of the antigenic structure of a large membrane autoantigen, the muscle-type nicotinic acetylcholine receptorQ47700102
Autoimmune Response to Acetylcholine ReceptorQ47996933
Bacterial expression of a single-chain Fv fragment which efficiently protects the acetylcholine receptor against antigenic modulation caused by myasthenic antibodiesQ48108093
Nicotinic acetylcholine receptor at 4.6 A resolution: transverse tunnels in the channel wallQ50146671
Growth hormone-albumin conjugates Reduced renal toxicity and altered plasma clearanceQ59540824
Myasthenia Gravis: Passive Transfer from Man to MouseQ67318954
Myasthenic Antibodies Cross-Link Acetylcholine Receptors to Accelerate DegradationQ67320379
Passive transfer of experimental myasthenia gravis via antigenic modulation of acetylcholine receptorQ68033058
Passive transfer of experimental autoimmune myasthenia gravis by monoclonal antibodies to the main immunogenic region of the acetylcholine receptorQ68821017
Interaction between AChR-specific T- and B-line lymphocytes: antigen presentation by B hybridoma cells and the enhancing effect of monoclonal antibodies on T-cell activationQ68834074
P433issue2
P921main subjectmyasthenia gravisQ8285
monoclonal antibodyQ422248
P304page(s)124-132
P577publication date2000-05-01
P1433published inJournal of NeuroimmunologyQ15716691
P1476titlePrevention of passively transferred experimental autoimmune myasthenia gravis by Fab fragments of monoclonal antibodies directed against the main immunogenic region of the acetylcholine receptor
P478volume104

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cites work (P2860)
Q42656803Analysis of peripheral B cells and autoantibodies against the anti-nicotinic acetylcholine receptor derived from patients with myasthenia gravis using single-cell manipulation tools
Q43789079Conjugation of acetylcholine receptor-protecting Fab fragments with polyethylene glycol results in a prolonged half-life in the circulation and reduced immunogenicity
Q27632866Crystal structure of Fab198, an efficient protector of the acetylcholine receptor against myasthenogenic antibodies
Q35738827Guidelines for pre-clinical assessment of the acetylcholine receptor--specific passive transfer myasthenia gravis model-Recommendations for methods and experimental designs
Q35708842Molecular outcomes of neuromyelitis optica (NMO)-IgG binding to aquaporin-4 in astrocytes
Q37409458MuSK IgG4 autoantibodies cause myasthenia gravis by inhibiting binding between MuSK and Lrp4.
Q44528925Prevention of passively transferred experimental autoimmune myasthenia gravis by an in vitro selected RNA aptamer
Q34831033The role of antibodies in myasthenia gravis
Q35520740Update on myasthenia gravis

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