NB-506, an indolocarbazole topoisomerase I inhibitor, binds preferentially to triplex DNA

scientific article published on 01 March 2000

NB-506, an indolocarbazole topoisomerase I inhibitor, binds preferentially to triplex DNA is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0014-5793(00)01335-1
P698PubMed publication ID10745096

P50authorJonathan B. ChairesQ41509784
P2093author name stringJ Ren
C Bailly
P2860cites workCalories from carbohydrates: energetic contribution of the carbohydrate moiety of rebeccamycin to DNA binding and the effect of its orientation on topoisomerase I inhibition.Q34503473
Production and biological activity of rebeccamycin, a novel antitumor agent.Q34685566
DNA cleavage by topoisomerase I in the presence of indolocarbazole derivatives of rebeccamycinQ34739014
NMR-Based model of a telomerase-inhibiting compound bound to G-quadruplex DNA.Q38333614
The interaction of intercalators and groove-binding agents with DNA triple-helical structures: the influence of ligand structure, DNA backbone modifications and sequenceQ40573573
Interactions of heteroaromatic compounds with nucleic acids. 1. The influence of heteroatoms and polarizability on the base specificity of intercalating ligandsQ41049075
A new antitumor substance, BE-13793C, produced by a streptomycete. Taxonomy, fermentation, isolation, structure determination and biological activityQ41678136
Stability and structure of model DNA triplexes and quadruplexes and their interactions with small ligands.Q41680421
New chemotherapeutic agents for the treatment of non-small cell lung cancer: the Japanese experienceQ41686970
Antimetastatic effect of a novel indolocarbazole (NB-506) on IMC-HM murine tumor cells metastasized to the liver.Q55090408
Molecular Anchoring of Duplex and Triplex DNA by Disubstituted Anthracene-9,10-diones: Calorimetric, UV Melting, and Competition Dialysis StudiesQ56453060
Triple helix-specific ligandsQ68162481
Interaction of drugs with Z-DNA: cooperative binding of actinomycin D or actinomine to the left-handed forms of poly(dG-dC).poly(dG-dC) and poly(dG-m5dC).poly(dG-m5dC) reverses the conformation of the helixQ68951875
Studies on interaction of anthracycline antibiotics and deoxyribonucleic acid: equilibrium binding studies on interaction of daunomycin with deoxyribonucleic acidQ70472805
Bromination stabilizes poly(dG-dC) in the Z-DNA form under low-salt conditionsQ71255365
Sequence and structural selectivity of nucleic acid binding ligandsQ73248196
Energetics of drug-DNA interactionsQ74561246
Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzymeQ77333600
Substitution at the F-ring N-imide of the indolocarbazole antitumor drug NB-506 increases the cytotoxicity, DNA binding, and topoisomerase I inhibition activitiesQ78055767
Ethidium binding to left-handed (Z) DNAs results in regions of right-handed DNA at the intercalation siteQ93669794
P433issue3
P304page(s)355-359
P577publication date2000-03-01
P1433published inFEBS LettersQ1388051
P1476titleNB-506, an indolocarbazole topoisomerase I inhibitor, binds preferentially to triplex DNA
P478volume470