PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27(KIP1) through the ubiquitin E3 ligase SCF(SKP2)

scientific article published on 01 February 2001

PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27(KIP1) through the ubiquitin E3 ligase SCF(SKP2) is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0960-9822(01)00065-3
P698PubMed publication ID11250155

P2093author name stringH Wu
H Sun
H Zhang
L M Tsvetkov
N Gavrilova
R Mamillapalli
V T Mihaylova
P2860cites workThe lipid phosphatase activity of PTEN is critical for its tumor supressor functionQ22007981
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphateQ24317714
CDK inhibitors: positive and negative regulators of G1-phase progressionQ27860983
p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27Q28137813
SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27Q28137860
PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathwayQ28588309
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathwayQ29616144
PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cellsQ33586807
Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27Q33887383
p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cellsQ40918524
Cyclin E-CDK2 is a regulator of p27Kip1.Q42800258
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)263-267
P577publication date2001-02-01
P1433published inCurrent BiologyQ1144851
P1476titlePTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27(KIP1) through the ubiquitin E3 ligase SCF(SKP2)
P478volume11