Electrospray ionization mass spectrometric analyses of phospholipids from INS-1 insulinoma cells: comparison to pancreatic islets and effects of fatty acid supplementation on phospholipid composition and insulin secretion

scientific article published on 01 April 2000

Electrospray ionization mass spectrometric analyses of phospholipids from INS-1 insulinoma cells: comparison to pancreatic islets and effects of fatty acid supplementation on phospholipid composition and insulin secretion is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S1388-1981(00)00022-6
P698PubMed publication ID10760474

P2093author name stringZ Ma
S Zhang
J Turk
A Bohrer
S Ramanadham
F Hsu
P2860cites workCloning, expression, and nutritional regulation of the mammalian Delta-6 desaturaseQ22008587
A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATIONQ25939000
Human Pancreatic Islets Express mRNA Species Encoding Two Distinct Catalytically Active Isoforms of Group VI Phospholipase A2 (iPLA2) [etc.]Q28139679
A novel cytosolic calcium-independent phospholipase A2 contains eight ankyrin motifsQ28306525
Leptin- or troglitazone-induced lipopenia protects islets from interleukin 1beta cytotoxicityQ28379134
Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo- and a Cys-His domainQ28564170
Pancreatic islets express a Ca2+-independent phospholipase A2 enzyme that contains a repeated structural motif homologous to the integral membrane protein binding domain of ankyrinQ28577938
Mass spectrometric identification and quantitation of arachidonate-containing phospholipids in pancreatic islets: prominence of plasmenylethanolamine molecular speciesQ28609563
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The Pancreatic Islet as Rubik's Cube: Is Phospholipid Hydrolysis a piece of the Puzzle?Q33344135
Nonmonotonic alterations in the fluorescence anisotropy of polar head group labeled fluorophores during the lamellar to hexagonal phase transition of phospholipidsQ34091535
Electrophysiology of stimulus-secretion coupling in human beta-cellsQ35378618
Electrospray ionization mass spectroscopic analysis of human erythrocyte plasma membrane phospholipidsQ35866657
Fatty acid-induced beta cell apoptosis: a link between obesity and diabetesQ35923385
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The regulation of stearoyl-CoA desaturase (SCD).Q40370626
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Expression of neuronal traits in pancreatic beta cells. Implication of neuron-restrictive silencing factor/repressor element silencing transcription factor, a neuron-restrictive silencer.Q41133907
Identity between the Ca2+-independent phospholipase A2 enzymes from P388D1 macrophages and Chinese hamster ovary cellsQ42436218
Arachidonic acid metabolism in isolated pancreatic islets. VI. Carbohydrate insulin secretagogues must be metabolized to induce eicosanoid releaseQ42460931
Pancreatic beta-cells in obesity. Evidence for induction of functional, morphologic, and metabolic abnormalities by increased long chain fatty acidsQ42488522
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Inhibition of phospholipase A2 and insulin secretion in pancreatic isletsQ44155266
Unmasking of arachidonate-induced insulin release by removal of extracellular calcium. Arachidonic acid mobilizes cellular calcium in rat islets of LangerhansQ44781140
Isolation of a Delta5-fatty acid desaturase gene from Mortierella alpinaQ48036153
Formation of lithiated adducts of glycerophosphocholine lipids facilitates their identification by electrospray ionization tandem mass spectrometryQ48311916
Electrospray ionization tandem mass spectrometric analysis of sulfatide. Determination of fragmentation patterns and characterization of molecular species expressed in brain and in pancreatic isletsQ48446714
Electrospray ionization mass spectrometric analyses of phospholipids from rat and human pancreatic islets and subcellular membranes: comparison to other tissues and implications for membrane fusion in insulin exocytosisQ48487309
Defective fatty acid-mediated beta-cell compensation in Zucker diabetic fatty rats. Pathogenic implications for obesity-dependent diabetes.Q51034319
Rapid plasmenylethanolamine-selective fusion of membrane bilayers catalyzed by an isoform of glyceraldehyde-3-phosphate dehydrogenase: discrimination between glycolytic and fusogenic roles of individual isoforms.Q52329372
Inhibition of glucose-induced insulin secretion by the diacylglycerol lipase inhibitor RHC 80267 and the phospholipase A2 inhibitor ACA through stimulation of K+ permeability without diminution by exogenous arachidonic acid.Q53970526
A Specific Inhibitor of Cytosolic Phospholipase A2Activity, AACOCF3, Inhibits Glucose-Induced Insulin Secretion from Isolated Rat IsletsQ57918001
Intracellular ATP directly blocks K+ channels in pancreatic B-cellsQ59072807
Enhanced de novo lipogenesis in the leptin-unresponsive pancreatic islets of prediabetic Zucker diabetic fatty rats: role in the pathogenesis of lipotoxic diabetesQ64381798
Generation and remodeling of phospholipid molecular species in rat hepatocytes.Q64883350
Fast atom bombardment tandem mass spectrometric identification of diacyl, alkylacyl, and alk-1-enylacyl molecular species of glycerophosphoethanolamine in human polymorphonuclear leukocytesQ67601863
Free fatty acid accumulation in secretagogue-stimulated pancreatic islets and effects of arachidonate on depolarization-induced insulin secretionQ67990767
Arachidonic acid induces an increase in the cytosolic calcium concentration in single pancreatic islet beta cellsQ68109820
Assessment of phospholipid deacylation-reacylation cycles by a stable isotope techniqueQ69743599
16 A subcellular fractionation approach for studying insulin release mechanisms and calcium metabolism in islets of langerhansQ70327051
Rat and human pancreatic islet cells contain a calcium ion independent phospholipase A2 activity selective for hydrolysis of arachidonate which is stimulated by adenosine triphosphate and is specifically localized to islet beta-cellsQ70526275
Inhibition of arachidonate release by secretagogue-stimulated pancreatic islets suppresses both insulin secretion and the rise in beta-cell cytosolic calcium ion concentrationQ70526279
Structural determinants of haloenol lactone-mediated suicide inhibition of canine myocardial calcium-independent phospholipase A2Q70531998
Alterations in individual molecular species of human platelet phospholipids during thrombin stimulation: electrospray ionization mass spectrometry-facilitated identification of the boundary conditions for the magnitude and selectivity of thrombin-inQ71099275
Characterization of an ATP-stimulatable Ca(2+)-independent phospholipase A2 from clonal insulin-secreting HIT cells and rat pancreatic islets: a possible molecular component of the beta-cell fuel sensorQ71994618
Plasmenylethanolamine facilitates rapid membrane fusion: a stopped-flow kinetic investigation correlating the propensity of a major plasma membrane constituent to adopt an HII phase with its ability to promote membrane fusionQ72413360
Mass spectrometric characterization of arachidonate-containing plasmalogens in human pancreatic islets and in rat islet beta-cells and subcellular membranesQ72648715
Alterations of fatty acyl turnover in macrophage glycerolipids induced by stimulation. Evidence for enhanced recycling of arachidonic acidQ73044862
Glucose-responsitivity and expression of an ATP-stimulatable, Ca(2+)-independent phospholipase A2 enzyme in clonal insulinoma cell linesQ73066769
Mass spectrometric evidence that agents that cause loss of Ca2+ from intracellular compartments induce hydrolysis of arachidonic acid from pancreatic islet membrane phospholipids by a mechanism that does not require a rise in cytosolic Ca2+ concentrQ77342881
Studies of the role of group VI phospholipase A2 in fatty acid incorporation, phospholipid remodeling, lysophosphatidylcholine generation, and secretagogue-induced arachidonic acid release in pancreatic islets and insulinoma cellsQ77726407
Structural determination of picomole amounts of phospholipids via electrospray ionization tandem mass spectrometryQ86698735
P433issue2-3
P407language of work or nameEnglishQ1860
P921main subjectinsulinomaQ1501239
P304page(s)251-266
P577publication date2000-04-01
P1433published inBiochimica et Biophysica ActaQ864239
P1476titleElectrospray ionization mass spectrometric analyses of phospholipids from INS-1 insulinoma cells: comparison to pancreatic islets and effects of fatty acid supplementation on phospholipid composition and insulin secretion
P478volume1484

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cites work (P2860)
Q40386417Adverse physicochemical properties of tripalmitin in beta cells lead to morphological changes and lipotoxicity in vitro
Q36097195Attenuated free cholesterol loading-induced apoptosis but preserved phospholipid composition of peritoneal macrophages from mice that do not express group VIA phospholipase A2.
Q43939927Delta6-, Stearoyl CoA-, and Delta5-desaturase enzymes are expressed in beta-cells and are altered by increases in exogenous PUFA concentrations
Q30407920Diabetic nephropathy induces alterations in the glomerular and tubule lipid profiles
Q36302173Effects of stable suppression of Group VIA phospholipase A2 expression on phospholipid content and composition, insulin secretion, and proliferation of INS-1 insulinoma cells
Q74307630Electrospray ionization mass spectrometric analyses of changes in tissue phospholipid molecular species during the evolution of hyperlipidemia and hyperglycemia in Zucker diabetic fatty rats
Q62070336Electrospray ionization tandem mass spectrometry scan modes for plant chloroplast lipids
Q33763658Evidence for proteolytic processing and stimulated organelle redistribution of iPLA(2)beta.
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Q34050555Inhibition of Ca2+-independent phospholipase A2 results in insufficient insulin secretion and impaired glucose tolerance
Q33195299Pancreatic islets and insulinoma cells express a novel isoform of group VIA phospholipase A2 (iPLA2 beta) that participates in glucose-stimulated insulin secretion and is not produced by alternate splicing of the iPLA2 beta transcript
Q33901997Role of fatty acid elongases in determination of de novo synthesized monounsaturated fatty acid species
Q43719219Studies of phospholipid metabolism, proliferation, and secretion of stably transfected insulinoma cells that overexpress group VIA phospholipase A2.
Q35675195The level of menadione redox-cycling in pancreatic β-cells is proportional to the glucose concentration: role of NADH and consequences for insulin secretion

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