Urokinase/urokinase receptor and vitronectin/alpha(v)beta(3) integrin induce chemotaxis and cytoskeleton reorganization through different signaling pathways

scientific article published on 01 April 2001

Urokinase/urokinase receptor and vitronectin/alpha(v)beta(3) integrin induce chemotaxis and cytoskeleton reorganization through different signaling pathways is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1034023090
P356DOI10.1038/SJ.ONC.1204261
P698PubMed publication ID11360187

P2093author name stringF Blasi
S Orlando
S A Rabbani
B Degryse
M Resnati
P2860cites workThe serpin PAI-1 inhibits cell migration by blocking integrin alpha V beta 3 binding to vitronectinQ24310652
Urokinase induces activation and formation of Stat4 and Stat1-Stat2 complexes in human vascular smooth muscle cellsQ28142061
The human N-formylpeptide receptor. Characterization of two cDNA isolates and evidence for a new subfamily of G-protein-coupled receptorsQ28243582
Role of vitronectin and its receptors in haemostasis and vascular remodelingQ28272554
Plasminogen activators, integrins, and the coordinated regulation of cell adhesion and migrationQ28610258
Myosin light chain kinase functions downstream of Ras/ERK to promote migration of urokinase-type plasminogen activator-stimulated cells in an integrin-selective mannerQ30304130
Urokinase-type plasminogen activator stimulates the Ras/Extracellular signal-regulated kinase (ERK) signaling pathway and MCF-7 cell migration by a mechanism that requires focal adhesion kinase, Src, and Shc. Rapid dissociation of GRB2/Sps-Shc complQ30305582
Binding of urokinase-type plasminogen activator to its receptor in MCF-7 cells activates extracellular signal-regulated kinase 1 and 2 which is required for increased cellular motilityQ30471919
Urokinase-type plasminogen activator receptor (CD87) is a ligand for integrins and mediates cell-cell interaction.Q31506532
Bidirectional signaling between the cytoskeleton and integrinsQ33597380
Growth factor activation of MAP kinase requires cell adhesion.Q33887464
A urokinase-sensitive region of the human urokinase receptor is responsible for its chemotactic activity.Q33887878
Urokinase receptor and integrin partnership: coordination of signaling for cell adhesion, migration and growth.Q34026314
Novel purification of vitronectin from human plasma by heparin affinity chromatography.Q34660214
alpha-2 Macroglobulin receptor/Ldl receptor-related protein(Lrp)-dependent internalization of the urokinase receptorQ36236343
Is plasminogen activator inhibitor-1 the molecular switch that governs urokinase receptor-mediated cell adhesion and release?Q36237406
Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptorsQ36257661
Urokinase receptor (CD87) regulates leukocyte recruitment via beta 2 integrins in vivo.Q36401755
Urokinase is required for the pulmonary inflammatory response to Cryptococcus neoformans. A murine transgenic modelQ37354110
The inhibition of vascular smooth muscle cell migration by peptide and antibody antagonists of the alphavbeta3 integrin complex is reversed by activated calcium/calmodulin- dependent protein kinase II.Q37370751
Phosphatidylinositol 3-kinaseQ40702617
Identification of a urokinase receptor-integrin interaction site. Promiscuous regulator of integrin functionQ40890085
Domain 1 of the urokinase receptor (uPAR) is required for uPAR-mediated cell binding to vitronectinQ40893088
Downstream targets of urokinase-type plasminogen-activator-mediated signal transductionQ41027822
Proteolytic cleavage of the urokinase receptor substitutes for the agonist-induced chemotactic effectQ41064411
Plasminogen activator inhibitor-1 represses integrin- and vitronectin-mediated cell migration independently of its function as an inhibitor of plasminogen activationQ41113160
Regulation of integrin function by the urokinase receptorQ41168373
uPA, uPAR, PAI-1: key intersection of proteolytic, adhesive and chemotactic highways?Q41591661
Selective localization of receptors for urokinase amino-terminal fragment at substratum contact sites of an in vitro-established line of human epidermal cellsQ41592577
Urokinase plasminogen activator receptor, beta 2-integrins, and Src-kinases within a single receptor complex of human monocytesQ42163142
Beta 1 and beta 3 integrins have different roles in the adhesion and migration of vascular smooth muscle cells on extracellular matrixQ42454200
Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signalingQ42478267
Regulation of anchorage-dependent signal transduction by protein kinase A and p21-activated kinaseQ42797515
Human urokinase-type plasminogen activator stimulates chemotaxis of human neutrophilsQ43881611
Interaction of urokinase with specific receptors stimulates mobilization of bovine adrenal capillary endothelial cells.Q45555792
Requirement of receptor-bound urokinase-type plasminogen activator for integrin alphavbeta5-directed cell migrationQ46797055
Beta3-integrins rather than beta1-integrins dominate integrin-matrix interactions involved in postinjury smooth muscle cell migrationQ48035533
The urokinase receptor is a major vitronectin-binding protein on endothelial cellsQ71034141
Inhibition of neointimal hyperplasia by blocking alpha V beta 3 integrin with a small peptide antagonist GpenGRGDSPCAQ71608650
Stimulation of migration of human aortic smooth muscle cells by vitronectin: implications for atherosclerosisQ71675475
Ligand interaction between urokinase-type plasminogen activator and its receptor probed with 8-anilino-1-naphthalenesulfonate. Evidence for a hydrophobic binding site exposed only on the intact receptorQ72089738
Cell-surface acceleration of urokinase-catalyzed receptor cleavageQ73067924
Melanoma cell migration on vitronectin: regulation by components of the plasminogen activation systemQ73209090
Urokinase stimulates human vascular smooth muscle cell migration via a phosphatidylinositol 3-kinase-Tyk2 interactionQ74338845
Insulin, growth factors, and cAMP: antagonism in the signal transduction pathwaysQ81066607
P433issue16
P407language of work or nameEnglishQ1860
P921main subjectchemotaxisQ658145
P304page(s)2032-2043
P577publication date2001-04-01
P1433published inOncogeneQ1568657
P1476titleUrokinase/urokinase receptor and vitronectin/alpha(v)beta(3) integrin induce chemotaxis and cytoskeleton reorganization through different signaling pathways
P478volume20

Reverse relations

cites work (P2860)
Q40355156An uncleavable uPAR mutant allows dissection of signaling pathways in uPA-dependent cell migration.
Q36749726Ang II-stimulated migration of vascular smooth muscle cells is dependent on LR11 in mice
Q41465764Bacterial endotoxin enhances colorectal cancer cell adhesion and invasion through TLR-4 and NF-kappaB-dependent activation of the urokinase plasminogen activator system
Q33933531CNN3 regulates trophoblast invasion and is upregulated by hypoxia in BeWo cells
Q40135411Calcitonin receptor-stimulated migration of prostate cancer cells is mediated by urokinase receptor-integrin signaling
Q81152153Chemokine-like factor 1 is a functional ligand for CC chemokine receptor 4 (CCR4)
Q48220228D2A sequence of the urokinase receptor induces cell growth through αvβ3 integrin and EGFR.
Q61799120Data on the inhibition of cell proliferation and invasion by the D2A-Ala peptide derived from the urokinase receptor
Q33959863Differences in integrin expression and signaling within human breast cancer cells
Q38601915Downregulation of urokinase plasminogen activator receptor expression inhibits Erk signalling with concomitant suppression of invasiveness due to loss of uPAR-beta1 integrin complex in colon cancer cells
Q35034871Impaired MicroRNA Processing Facilitates Breast Cancer Cell Invasion by Upregulating Urokinase-Type Plasminogen Activator Expression
Q47188768Inhibition of angiogenesis by two-chain high molecular weight kininogen (HKa) and kininogen-derived polypeptides
Q37081801LRP-1: a new modulator of cytoskeleton dynamics and adhesive complex turnover in cancer cells
Q35107356Maspin, the molecular bridge between the plasminogen activator system and beta1 integrin that facilitates cell adhesion
Q34540644Multi-tissue microarray analysis identifies a molecular signature of regeneration
Q74535973PAI-1 inhibits urokinase-induced chemotaxis by internalizing the urokinase receptor
Q83162820Plasminogen activator inhibitor-1: the double-edged sword in apoptosis
Q44222507Pro-collagen I COOH-terminal trimer induces directional migration and metalloproteinases in breast cancer cells
Q30157380Proteomic identification of LASP-1 down-regulation after RNAi urokinase silencing in human hepatocellular carcinoma cells
Q34601099RNAi-mediated downregulation of urokinase plasminogen activator and its receptor in human meningioma cells inhibits tumor invasion and growth
Q36321377Regulation of alpha5beta1 integrin conformation and function by urokinase receptor binding.
Q24296406Stabilization of Urokinase and Urokinase Receptor mRNAs by HuR Is Linked to Its Cytoplasmic Accumulation Induced by Activated Mitogen-Activated Protein Kinase-Activated Protein Kinase 2
Q28570659The high mobility group (HMG) boxes of the nuclear protein HMG1 induce chemotaxis and cytoskeleton reorganization in rat smooth muscle cells
Q35556137The nuclear protein HMGB1, a new kind of chemokine?
Q35085325The role of the plasminogen activation cascade in glioma cell invasion: a review.
Q36322653The syndecan-1 ectodomain regulates alphavbeta3 integrin activity in human mammary carcinoma cells
Q36908422The vitronectin-binding domain of plasminogen activator inhibitor-1 plays an important functional role in lipopolysaccharide-induced lethality in mice
Q35124141Urokinase and its receptors in chronic kidney disease.
Q35901840Urokinase receptor cleavage: a crucial step in fibroblast-to-myofibroblast differentiation
Q37432551Urokinase type plasminogen activator receptor (uPAR) as a new therapeutic target in cancer
Q24529131Urokinase-induced signaling in human vascular smooth muscle cells is mediated by PDGFR-beta
Q50692022uPA-uPAR molecular complex is involved in cell signaling during neuronal migration and neuritogenesis.
Q43951136uPA/PAI-1 expression and uPA promoter methylation in meningiomas
Q34162183uPAR: a versatile signalling orchestrator

Search more.