A synthetic miniprotein that binds specific DNA sequences by contacting both the major and the minor groove

scientific article published on 01 August 2003

A synthetic miniprotein that binds specific DNA sequences by contacting both the major and the minor groove is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S1074-5521(03)00172-8
P698PubMed publication ID12954330

P50authorM. Eugenio Vazquez SentisQ43098434
Jose M Martinez-CostasQ50528624
José L MascareñasQ56954307
P2093author name stringLuis Castedo
Juan B Blanco
P2860cites workDesign and Synthesis of a Peptide That Binds Specific DNA Sequences through Simultaneous Interaction in the Major and in the Minor Groove This work was supported by the Spanish M.E.C. (PB97-0524) and the Xunta de Galicia (PGIDT00PXI20912PR). M.E.V.Q95391625
An overview of the structures of protein-DNA complexesQ24804125
The GCN4 basic region leucine zipper binds DNA as a dimer of uninterrupted alpha helices: crystal structure of the protein-DNA complexQ27642986
A bifurcated hydrogen-bonded conformation in the d(A.T) base pairs of the DNA dodecamer d(CGCAAATTTGCG) and its complex with distamycinQ27728606
Hin recombinase bound to DNA: the origin of specificity in major and minor groove interactionsQ27731526
Molecular recognition of DNA by small moleculesQ28216029
Concerted evolution of structure and function in a miniature proteinQ28344108
Transcription factors: structural families and principles of DNA recognitionQ29615317
Transcriptional activation: a complex puzzle with few easy piecesQ29616518
Nuclear-receptor interactions on DNA-response elementsQ34282476
Combinatorial transcription factors.Q34477875
Recognition in the minor groove of double-stranded DNA by microgonotropensQ34535932
Chemical approaches untangling sequence-specific DNA binding by proteinsQ34986429
Interaction of minor groove ligands to an AAATT/AATTT site: correlation of thermodynamic characterization and solution structureQ36720129
The single Cys2-His2 zinc finger domain of the GAGA protein flanked by basic residues is sufficient for high-affinity specific DNA binding.Q37677517
Transcriptional regulation by dimerization: two sides to an incestuous relationshipQ37909289
GCN4 binds with high affinity to DNA sequences containing a single consensus half-siteQ38311899
Altered specificity of DNA-binding proteins with transition metal dimerization domainsQ38322327
Comparison of the sequence-selective DNA binding by peptide dimers with covalent and noncovalent dimerization domainsQ38328682
Circular dichroic and kinetic differentiation of DNA binding modes of distamycinQ38334556
Multi-helical DNA-binding domains: their structures and modes of DNA-bindingQ41090513
The DNA binding domain of the rat liver nuclear protein C/EBP is bipartiteQ41260447
Thermal unfolding studies of a leucine zipper domain and its specific DNA complex: implications for scissor's grip recognitionQ43405608
Design of DNA-binding peptides based on the leucine zipper motifQ43459773
Leucine repeats and an adjacent DNA binding domain mediate the formation of functional cFos-cJun heterodimersQ46196460
Sequence-specific DNA binding by a short peptide dimerQ68893024
Deconstruction of GCN4/GCRE into a monomeric peptide-DNA complexQ72033302
A Light-Modulated Sequence-Specific DNA-Binding Peptide This work was supported by the Spanish M.E.C. (PB97-0524) and the Xunta de Galicia (XUGA 20906B96). A.M.C and E.V. thank the Xunta de Galicia and the University of Santiago for their predoctoraQ73068416
Polyvalent Interactions in Biological Systems: Implications for Design and Use of Multivalent Ligands and InhibitorsQ88519588
P433issue8
P304page(s)713-722
P577publication date2003-08-01
P1433published inChemistry and BiologyQ15758410
P1476titleA synthetic miniprotein that binds specific DNA sequences by contacting both the major and the minor groove
P478volume10

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cites work (P2860)
Q42572321A designed DNA binding motif that recognizes extended sites and spans two adjacent major grooves
Q55131696DNA-binding miniproteins based on zinc fingers. Assessment of the interaction using nanopores.
Q38624989Light-Controlled Cellular Internalization and Cytotoxicity of Nucleic Acid-Binding Agents: Studies in Vitro and in Zebrafish Embryos
Q48151736Metal-Dependent DNA Recognition and Cell Internalization of Designed, Basic Peptides
Q45275182Stimuli-responsive selection of target DNA sequences by synthetic bZIP peptides.
Q40162731Synthesis, Characterization, and DNA Binding Profile of a Macrocyclic β-Sheet Analogue of ARC Protein
Q42030290The AT-Hook motif as a versatile minor groove anchor for promoting DNA binding of transcription factor fragments

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