The endothelium is an extrahepatic site of synthesis of the seventh component of the complement system

scientific article published on 01 July 2000

The endothelium is an extrahepatic site of synthesis of the seventh component of the complement system is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1046/J.1365-2249.2000.01238.X
P932PMC publication ID1905676
P698PubMed publication ID10886241

P2093author name stringE Johnson
F Tedesco
C Casarsa
H Langeggen
M Pausa
P2860cites workCleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Q25938983
Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteriaQ29616614
Two distinct abnormalities in patients with C8 alpha-gamma deficiency. Low level of C8 beta chain and presence of dysfunctional C8 alpha-gamma subunitQ34260629
Regulation of the synthesis of C1 subcomponents and C1-inhibitorQ34340423
Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human beta-actin cDNA.Q35264401
The third component of complement is transcribed and secreted by cultured human endothelial cellsQ35856227
Interferon gamma induces synthesis of complement alternative pathway proteins by human endothelial cells in cultureQ36355520
Complement biosynthesis by the human hepatoma-derived cell line HepG2Q36987205
Mononuclear phagocytes have the potential to synthesize the complete functional complement systemQ39643657
Effect of cytokines on the secretion of the fifth and eighth complement components by HepG2 cellsQ41498663
Endothelial cells in physiology and in the pathophysiology of vascular disordersQ41757874
Reactive lysis: the complement-mediated lysis of unsensitized cells. II. The characterization of activated reactor as C56 and the participation of C8 and C9.Q41762392
The cytolytically inactive terminal complement complex activates endothelial cells to express adhesion molecules and tissue factor procoagulant activityQ41923727
In vitro biosynthesis of complement factor I by human endothelial cellsQ42459180
Biosynthesis of C3 by human mesangial cells. Modulation by proinflammatory cytokinesQ42477501
Monoclonal antibodies recognizing a neoantigen of poly(C9) detect the human terminal complement complex in tissue and plasmaQ43762567
The C5b-6 complex: formation, isolation, and inhibition of its activity by lipoprotein and the S-protein of human serumQ43767406
Human umbilical vein endothelial cells synthesize functional C3, C5, C6, C8 and C9 in vitroQ44091595
Complement activation occurs on subendothelial extracellular matrix in vitro and is initiated by retraction or removal of overlying endothelial cellsQ47936495
Biosynthesis of complement factor H by human umbilical vein endothelial cells. Regulation by T cell growth factor and IFN-gamma.Q54357513
Molecular bases of combined subtotal deficiencies of C6 and C7: their effects in combination with other C6 and C7 deficienciesQ55670899
Organ-specific contribution to circulating C7 levels by the bone marrow and liver in humansQ57089607
Differential regulation of complement factor H and C3 production in human umbilical vein endothelial cells by IFN-gamma and IL-1Q68416575
Expression of complement alternative pathway proteins by endothelial cells. Differential regulation by interleukin 1 and glucocorticoidsQ68428812
Synthesis of complement components C5, C6, C7, C8 and C9 in vitro by human monocytes and assembly of the terminal complement complexQ69629002
Biosynthesis and secretion of the third component of complement by human endothelial cells in vitroQ70341351
Interleukin-1 alpha, interleukin 6 and tumor necrosis factor alpha increase the synthesis and expression of the functional alternative and terminal complement pathways by human umbilical vein endothelial cells in vitroQ71027197
How partial C7 deficiency with chronic and recurrent bacterial infections can mimic total C7 deficiency: temporary restoration of host C7 levels following plasma transfusionQ71446674
Human polymorphonuclear leukocytes store large amounts of terminal complement components C7 and C6, which may be released on stimulationQ72169141
Paradoxical reconstitution of complement activity following plasma transfusion of an individual with deficiency of the seventh component of complementQ72302250
Complement component C7. Assessment of in vivo synthesis after liver transplantation reveals that hepatocytes do not synthesize the majority of human C7Q72363605
Effect of gamma-interferon on the synthesis of the functional alternative and terminal complement pathways by human umbilical vein endothelial cells in vitroQ72693834
P433issue1
P304page(s)69-76
P577publication date2000-07-01
P1433published inClinical and Experimental ImmunologyQ15716708
P1476titleThe endothelium is an extrahepatic site of synthesis of the seventh component of the complement system
P478volume121

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cites work (P2860)
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