A 6beta-(thiaheptanamide) derivative of estradiol as inhibitor of 17beta-hydroxysteroid dehydrogenase type 1

scientific article published on 01 January 1998

A 6beta-(thiaheptanamide) derivative of estradiol as inhibitor of 17beta-hydroxysteroid dehydrogenase type 1 is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0960-0760(97)00136-2
P698PubMed publication ID9569013

P2093author name stringD Poirier
S Auger
P Dionne
P2860cites workThe key role of 17 beta-hydroxysteroid dehydrogenases in sex steroid biologyQ28303450
Structure of the steroid-binding site of human placental estradiol-17β-dehydrogenaseQ28331163
Characteristics of human types 1, 2 and 3 17 beta-hydroxysteroid dehydrogenase activities: oxidation/reduction and inhibitionQ28646522
Synthesis of 16-(bromoalkyl)-estradiols having inhibitory effect on human placental estradiol 17β-hydroxysteroid dehydrogenase (17-β-HSD type 1)Q34303094
Characterization of cDNAs for human estradiol 17 beta-dehydrogenase and assignment of the gene to chromosome 17: evidence of two mRNA species with distinct 5'-termini in human placentaQ34543730
Characterization of two mRNA species encoding human estradiol 17 beta-dehydrogenase and assignment of the gene to chromosome 17.Q35169450
IntracrinologyQ37124969
A discussion of the roles of oestrogen and progestin in human mammary carcinogenesisQ37525744
Alkylation of Estradiol 17beta-Dehydrogenase from Human Placenta with 3-Chloroacetylpyridine - Adenine DinucleotideQ39088987
Comparison of the in vitro conversion of estradiol-17β to estrone of normal and neoplastic human breast tissueQ39136597
Do hormones cause breast cancer?Q40167813
Synthesis and biological activities of thioether derivatives related to the antiestrogens tamoxifen and ICI 164384.Q41337772
8th San Antonio Breast Cancer Symposium--Plenary lecture. Autocrine and paracrine growth regulation of human breast cancerQ41366482
Preparation of 14,15-secoestra-1,3,5(10)-trien-15-ynes, inhibitors of estradiol dehydrogenaseQ42199022
The affinity alkylators, 11 alpha-bromoacetoxyprogesterone and estrone 3-bromoacetate, modify a common histidyl residue in the active site of human placental 17 beta,20 alpha-hydroxysteroid dehydrogenaseQ42216100
Cancer statistics, 1994.Q43560974
Distribution of 17 beta-hydroxysteroid dehydrogenase gene expression and activity in rat and human tissuesQ48524479
Expression of human 17β-hydroxysteroid dehydrogenase in mammalian cellsQ67487485
Human placental estradiol 17 beta-dehydrogenase: evidence for inverted substrate orientation ("wrong-way" binding) at the active siteQ67926252
Hydrogen bonding in steroidogenesis: studies on new heterocyclic analogs of estrone that inhibit human estradiol 17 beta-dehydrogenaseQ68061527
Estradiol binding and metabolism in human endometrial hyperplasia and adenocarcinomaQ68267602
Mechanism-based inactivation of 17 beta,20 alpha-hydroxysteroid dehydrogenase by an acetylenic secoestradiolQ68748455
Trifluoromethylacetylenic alcohols as affinity labels: inactivation of estradiol dehydrogenase by a trifluoromethylacetylenic secostradiolQ68898162
Progestin effect on cell proliferation and 17 beta-hydroxysteroid dehydrogenase activity in normal human breast cells in cultureQ68974206
Metabolism of [3H]oestradiol in vivo by normal breast and tumour tissue in postmenopausal womenQ69496574
A comparison of the in vivo uptake and metabolism of 3H-oestrone and 3H-oestradiol by normal breast and breast tumour tissues in post-menopausal womenQ69570155
Affinity labeling of the cofactor-binding site of estradiol 17 beta-dehydrogenase of human placenta by 5'-p-fluorosulfonylbenzoyl adenosineQ69840136
17 beta-Hydroxysteroid oxidoreductase: a ubiquitous enzyme. Interconversion of estrone and estradiol-17 beta in BALB/c mouse tissuesQ69845448
Aromatase, 17 beta-hydroxysteroid dehydrogenase and intratissular sex hormone concentrations in cancerous and normal glandular breast tissue in postmenopausal womenQ70144075
The relationship between 17 beta-hydroxysteroid dehydrogenase activity and oestrogen concentrations in human breast tumours and in normal breast tissueQ70179417
Inhibition of estrone sulfatase and 17 beta-hydroxysteroid dehydrogenase by antiestrogensQ70457028
13C nuclear magnetic resonance study of 17 alpha-substituted estradiolsQ71125482
Estradiol 17 beta-hydroxysteroid dehydrogenase activity in human breast fibroadenomasQ72042983
1H and 13C nuclear magnetic resonance assignments and stereochemistry of N-n-butyl-N-methyl-11-(16'alpha-chloro-3',17'beta- and 17'alpha-dihydroxyestra-1',3',5'(10')-trien-7'alpha-yl) undecanamideQ72869177
P433issue1-2
P921main subjecthydroxysteroidQ2157080
P304page(s)83-90
P577publication date1998-01-01
P1433published inThe Journal of Steroid Biochemistry and Molecular BiologyQ15708871
P1476titleA 6beta-(thiaheptanamide) derivative of estradiol as inhibitor of 17beta-hydroxysteroid dehydrogenase type 1
P478volume64

Reverse relations

cites work (P2860)
Q7321502417Alpha-alkan (or alkyn) amide derivatives of estradiol as inhibitors of steroid-sulfatase activity
Q31110440A multidetachable sulfamate linker successfully used in a solid-phase strategy to generate libraries of sulfamate and phenol derivatives
Q40841145Androsterone 3beta-substituted derivatives as inhibitors of type 3 17beta-hydroxysteroid dehydrogenase
Q31875242Inhibitors of type II 17beta-hydroxysteroid dehydrogenase
Q40888023N-Butyl-N-methyl-11-(3'-hydroxy-21', 17'-carbolactone-19'-nor-17'alpha-pregna-1',3', 5'(10')-trien-7'alpha-yl)-undecanamide: an inhibitor of type 2 17beta-hydroxysteroid dehydrogenase that does not have oestrogenic or androgenic activity
Q41007647Overview of a rational approach to design type I 17beta-hydroxysteroid dehydrogenase inhibitors without estrogenic activity: chemical synthesis and biological evaluation
Q33869561Spironolactone-related inhibitors of type II 17beta-hydroxysteroid dehydrogenase: chemical synthesis, receptor binding affinities, and proliferative/antiproliferative activities
Q56764589Synthesis of a First Estradiol-Adenosine Hybrid Compound
Q53992034Two non-reactive ternary complexes of estrogenic 17beta-hydroxysteroid dehydrogenase: crystallization and preliminary structural analysis.