Prediction of membrane permeability to peptides from calculated dynamic molecular surface properties

scientific article published on 01 February 1999

Prediction of membrane permeability to peptides from calculated dynamic molecular surface properties is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1023/A:1018816122458
P698PubMed publication ID10100304

P2093author name stringP Stenberg
P Artursson
K Luthman
P2860cites workExperimental and computational approaches to estimate solubility and permeability in drug discovery and development settingsQ27861111
Caco-2 monolayers in experimental and theoretical predictions of drug transportQ33939098
The relationship between permeant size and permeability in lipid bilayer membranesQ34323828
Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cellsQ34532617
Structural specificity of mucosal-cell transport and metabolism of peptide drugs: implication for oral peptide drug deliveryQ35415314
Lipophilicity in molecular modelingQ41023171
Prodrugs revisited: the "ad hoc" approach as a complement to ligand designQ41051255
A computer perspective of membranes: molecular dynamics studies of lipid bilayer systemsQ41725777
The nature of the hydrophobic binding of small peptides at the bilayer interface: implications for the insertion of transbilayer helicesQ46052669
A practitioner's perspective of the role of quantitative structure-activity analysis in medicinal chemistryQ52740032
Polar molecular surface properties predict the intestinal absorption of drugs in humans.Q55067034
Theoretical calculation and prediction of Caco-2 cell permeability using MolSurf parametrization and PLS statisticsQ59188938
Partitioning of solutes in different solvent systems: the contribution of hydrogen-bonding capacity and polarityQ68044426
Evidence for a polarized efflux system for peptides in the apical membrane of Caco-2 cellsQ70575574
Correlation of drug absorption with molecular surface propertiesQ71795029
A correlation between the permeability characteristics of a series of peptides using an in vitro cell culture model (Caco-2) and those using an in situ perfused rat ileum model of the intestinal mucosaQ72760478
P433issue2
P304page(s)205-212
P577publication date1999-02-01
P1433published inPharmaceutical ResearchQ7180737
P1476titlePrediction of membrane permeability to peptides from calculated dynamic molecular surface properties
P478volume16

Reverse relations

cites work (P2860)
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