Telomeres, the nucleolus and aging

scientific article published on 01 June 1998

Telomeres, the nucleolus and aging is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/S0955-0674(98)80008-2
P698PubMed publication ID9640533

P50authorLeonard P. GuarenteQ6525606
P2093author name stringR A Marciniak
F B Johnson
P2860cites workhEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalizationQ24310670
Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRTQ24313396
Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2Q24317670
Control of telomere length by the human telomeric protein TRF1Q24320111
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4aQ24324559
Extension of life-span by introduction of telomerase into normal human cellsQ24336088
A biomarker that identifies senescent human cells in culture and in aging skin in vivoQ24562644
Specific Association of Human Telomerase Activity with Immortal Cells and CancerQ27860801
Constancy of ribosomal RNA genes during aging of mouse heart cells and during serial passage of WI-38 cells.Q54788706
Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cellsQ57250868
Human homologues of yeast helicaseQ59094515
Reexpression of the retinoblastoma protein in tumor cells induces senescence and telomerase inhibitionQ63446341
Loss of hybridizable ribosomal DNA from human post-mitotic tissues during aging: I. Age-dependent loss in human myocardiumQ66986632
Similar, but not identical, modulation of expression of extracellular matrix components during in vitro and in vivo aging of human skin fibroblastsQ67590227
In vivo loss of telomeric repeats with age in humansQ68048615
A subthreshold level of DNA topoisomerases leads to the excision of yeast rDNA as extrachromosomal ringsQ69351023
Loss of transcriptional silencing causes sterility in old mother cells of S. cerevisiaeQ70993045
Telomerase activity concentrates in the mitotically active segments of human hair folliclesQ71937963
Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae.Q27931333
A protein-counting mechanism for telomere length regulation in yeast.Q27932745
Accelerated aging and nucleolar fragmentation in yeast sgs1 mutantsQ27933022
Mitotic recombination in the rDNA of S. cerevisiae is suppressed by the combined action of DNA topoisomerases I and II.Q27933954
Sgs1: a eukaryotic homolog of E. coli RecQ that interacts with topoisomerase II in vivo and is required for faithful chromosome segregationQ27939683
The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyraseQ28170377
Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomasQ28258624
A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenonQ28639770
Mutation in the silencing gene S/R4 can delay aging in S. cerevisiaeQ29397443
Telomeres shorten during ageing of human fibroblastsQ29547357
Telomere shortening and tumor formation by mouse cells lacking telomerase RNAQ29615386
Telomerase catalytic subunit homologs from fission yeast and humanQ29615387
Extrachromosomal rDNA circles--a cause of aging in yeastQ29618308
Telomerase activity: a biomarker of cell proliferation, not malignant transformationQ33719153
In vivo telomere dynamics of human hematopoietic stem cellsQ33726870
Telomere length and replicative aging in human vascular tissuesQ33763501
Telomerase activity in normal and malignant hematopoietic cellsQ33883794
ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase.Q33887607
The telomere hypothesis of cellular agingQ33973605
Extrachromosomal circular DNAs and genomic sequence plasticity in eukaryotic cellsQ34134591
Telomerase activity in the regenerative basal layer of the epidermis inhuman skin and in immortal and carcinoma-derived skin keratinocytesQ34387542
Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblastsQ35927191
Telomere length constancy during aging of Saccharomyces cerevisiaeQ36163972
Regulated expression of telomerase activity in human T lymphocyte development and activationQ36366852
Changes of telomere length cause reciprocal changes in the lifespan of mother cells in Saccharomyces cerevisiaeQ36574621
Telomere lengthening and telomerase activation during human B cell differentiationQ36596432
Reversible cellular senescence: implications for immortalization of normal human diploid fibroblastsQ36770102
Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types.Q36885740
Decreased synthesis of nucleolar RNA in aging human cells in vitroQ36897324
Heterogeneity in telomere length of human chromosomes.Q39426746
Telomerase and cancer: revisiting the telomere hypothesisQ41211805
Telomerase activity is induced by the stimulation to antigen receptor in human peripheral lymphocytesQ41228429
Differential expression of telomerase activity in hematopoietic progenitors from adult human bone marrowQ42528725
Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblastsQ42815554
Age-related increase in methylation of ribosomal genes and inactivation of chromosome-specific rRNA gene clusters in mouseQ49015368
Loss of hybridizable ribosomal DNA from human post-mitotic tissues during aging: II. Age-dependent loss in human cerebral cortex — Hippocampal and somatosensory cortex comparisonQ52106096
A longitudinal study of human age-related ribosomal RNA gene activity as detected by silver-stained NORs.Q52198007
Up-regulation of telomerase activity in human lymphocytes.Q53448795
P433issue3
P304page(s)332-338
P577publication date1998-06-01
P1433published inCurrent Opinion in Cell BiologyQ13505682
P1476titleTelomeres, the nucleolus and aging
P478volume10