| scholarly article | Q13442814 |
| P356 | DOI | 10.1016/S0076-6879(02)43145-X |
| P698 | PubMed publication ID | 11665578 |
| P50 | author | Harel Weinstein | Q62642462 |
| P2093 | author name string | Juan A Ballesteros | |
| Irache Visiers | |||
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| Modeling of loops in protein structures | Q29615861 | ||
| Prediction of protein structure from sequence | Q30401942 | ||
| Can three-dimensional contacts in protein structures be predicted by analysis of correlated mutations? | Q30421171 | ||
| Automated method for modeling seven-helix transmembrane receptors from experimental data | Q30423649 | ||
| Bridging the protein sequence-structure gap by structure predictions | Q30425096 | ||
| Advances in comparative protein-structure modelling | Q30426879 | ||
| Molecular dynamics simulations predict a tilted orientation for the helical region of dynorphin A(1-17) in dimyristoylphosphatidylcholine bilayers | Q30618753 | ||
| The agonist SR 146131 and the antagonist SR 27897 occupy different sites on the human CCK(1) receptor | Q31440265 | ||
| Challenges at the frontiers of structural biology | Q33803964 | ||
| Uncovering molecular mechanisms involved in activation of G protein-coupled receptors | Q33851363 | ||
| Agonists induce conformational changes in transmembrane domains III and VI of the beta2 adrenoceptor | Q33887729 | ||
| The transmembrane 7-alpha-bundle of rhodopsin: distance geometry calculations with hydrogen bonding constraints | Q33915369 | ||
| Amino acid substitution matrices | Q33928587 | ||
| Specific tryptophan UV-absorbance changes are probes of the transition of rhodopsin to its active state | Q71466162 | ||
| Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin | Q71669056 | ||
| Structure and function in rhodopsin. Cysteines 65 and 316 are in proximity in a rhodopsin mutant as indicated by disulfide formation and interactions between attached spin labels | Q71775597 | ||
| Related contribution of specific helix 2 and 7 residues to conformational activation of the serotonin 5-HT2A receptor | Q71921157 | ||
| Construction of a 3D model of the cannabinoid CB1 receptor: determination of helix ends and helix orientation | Q72302114 | ||
| Predicting local structural changes that result from point mutations | Q72543386 | ||
| Modeling of transmembrane seven helix bundles | Q72949676 | ||
| Dopamine D4/D2 receptor selectivity is determined by A divergent aromatic microdomain contained within the second, third, and seventh membrane-spanning segments | Q73201596 | ||
| Interactions between conserved residues in transmembrane helices 1, 2, and 7 of the thyrotropin-releasing hormone receptor | Q73257857 | ||
| Structural probing of a microdomain in the dopamine transporter by engineering of artificial Zn2+ binding sites | Q73313425 | ||
| Theoretical study on mutation-induced activation of the luteinizing hormone receptor | Q73501706 | ||
| Constitutive activation of the beta2 adrenergic receptor alters the orientation of its sixth membrane-spanning segment | Q73520820 | ||
| Identification of conserved aromatic residues essential for agonist binding and second messenger production at 5-hydroxytryptamine2A receptors | Q73626765 | ||
| Partial agonism through a zinc-Ion switch constructed between transmembrane domains III and VII in the tachykinin NK(1) receptor | Q74045591 | ||
| A cluster of aromatic residues in the sixth membrane-spanning segment of the dopamine D2 receptor is accessible in the binding-site crevice | Q74137765 | ||
| Structure-derived substitution matrices for alignment of distantly related sequences | Q74241875 | ||
| Combined biophysical and biochemical information confirms arrangement of transmembrane helices visible from the three-dimensional map of frog rhodopsin | Q77116556 | ||
| Analysis and refinement of criteria for predicting the structure and relative orientations of transmembranal helical domains | Q34089075 | ||
| Hinges, swivels and switches: the role of prolines in signalling via transmembrane alpha-helices | Q34106483 | ||
| A proposed structure for transmembrane segment 7 of G protein-coupled receptors incorporating an asn-Pro/Asp-Pro motif | Q34168551 | ||
| Opioid receptor three-dimensional structures from distance geometry calculations with hydrogen bonding constraints | Q34168561 | ||
| The role of a conserved proline residue in mediating conformational changes associated with voltage gating of Cx32 gap junctions | Q34170537 | ||
| A 3D-1D substitution matrix for protein fold recognition that includes predicted secondary structure of the sequence | Q34424634 | ||
| Correlated mutations contain information about protein-protein interaction | Q34437670 | ||
| Molecular characterization of a functional cDNA encoding the serotonin 1c receptor | Q34688040 | ||
| The ligand-binding domain of rhodopsin and other G protein-linked receptors | Q35233191 | ||
| Adrenergic receptors as models for G protein-coupled receptors | Q36064980 | ||
| Conformational analysis and clustering of short and medium size loops connecting regular secondary structures: a database for modeling and prediction | Q36279619 | ||
| Proline residues in transmembrane helices: structural or dynamic role? | Q37301112 | ||
| The guanine nucleotide regulatory protein-coupled receptors for nucleosides, nucleotides, amino acids and amine neurotransmitters | Q38327952 | ||
| The bacterial photosynthetic reaction center as a model for membrane proteins | Q38686696 | ||
| Low resolution structure of bovine rhodopsin determined by electron cryo-microscopy. | Q39660441 | ||
| Serine and threonine residues bend alpha-helices in the chi(1) = g(-) conformation. | Q40174238 | ||
| Principles that determine the structure of proteins | Q40186639 | ||
| Receptors and G proteins as primary components of transmembrane signal transduction. Part 1. G-protein-coupled receptors: structure and function. | Q40456043 | ||
| Structure and function of receptors coupled to G proteins | Q40668280 | ||
| 3D modeling, ligand binding and activation studies of the cloned mouse delta, mu; and kappa opioid receptors | Q40787493 | ||
| Structural instability of a constitutively active G protein-coupled receptor. Agonist-independent activation due to conformational flexibility | Q41132503 | ||
| Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F. | Q41166407 | ||
| Residues in the seventh membrane-spanning segment of the dopamine D2 receptor accessible in the binding-site crevice. | Q41169045 | ||
| Mapping the binding site pocket of the serotonin 5-Hydroxytryptamine2A receptor. Ser3.36(159) provides a second interaction site for the protonated amine of serotonin but not of lysergic acid diethylamide or bufotenin | Q41190796 | ||
| Arrangement of transmembrane domains in adrenergic receptors. Similarity to bacteriorhodopsin | Q41229979 | ||
| A General Method for Mapping Tertiary Contacts between Amino Acid Residues in Membrane-Embedded Proteins | Q41269771 | ||
| Mutational analysis of the relative orientation of transmembrane helices I and VII in G protein-coupled receptors | Q41310090 | ||
| Mapping the binding-site crevice of the dopamine D2 receptor by the substituted-cysteine accessibility method | Q41354030 | ||
| Conversion of antagonist-binding site to metal-ion site in the tachykinin NK-1 receptor. | Q41361735 | ||
| An algorithm for secondary structure determination in proteins based on sequence similarity | Q41472347 | ||
| The role of conserved aspartate and serine residues in ligand binding and in function of the 5-HT1A receptor: a site-directed mutation study | Q41594566 | ||
| An alpha-carbon template for the transmembrane helices in the rhodopsin family of G-protein-coupled receptors | Q41633574 | ||
| Similar structures and shared switch mechanisms of the beta2-adrenoceptor and the parathyroid hormone receptor. Zn(II) bridges between helices III and VI block activation | Q41670110 | ||
| Environment-specific amino acid substitution tables: tertiary templates and prediction of protein folds | Q41875481 | ||
| Sensitivity comparison of protein amino acid sequences | Q42013583 | ||
| Conserved polar residues in the transmembrane domain of the human tachykinin NK2 receptor: functional roles and structural implications | Q42993189 | ||
| Differences in conformational properties of the second intracellular loop (IL2) in 5HT(2C) receptors modified by RNA editing can account for G protein coupling efficiency | Q43690562 | ||
| On the spatial disposition of the fifth transmembrane helix and the structural integrity of the transmembrane binding site in the opioid and ORL1 G protein-coupled receptor family | Q44332380 | ||
| Comparative modeling and molecular dynamics studies of the delta, kappa and mu opioid receptors | Q44347900 | ||
| Conformational changes of cytosolic loops of bovine rhodopsin during the transition to metarhodopsin-II: an investigation by Fourier transform infrared difference spectroscopy | Q45009676 | ||
| Proline for alanine substitutions in the C-peptide helix of ribonuclease A. | Q46082624 | ||
| Structural features and light-dependent changes in the cytoplasmic interhelical E-F loop region of rhodopsin: a site-directed spin-labeling study | Q46364800 | ||
| What makes red visual pigments red? A resonance Raman microprobe study of retinal chromophore structure in iodopsin | Q46370018 | ||
| Influence of proline residues on protein conformation | Q47638868 | ||
| Functional interaction of transmembrane helices 3 and 6 in rhodopsin. Replacement of phenylalanine 261 by alanine causes reversion of phenotype of a glycine 121 replacement mutant. | Q50533149 | ||
| Site-directed mutagenesis of the human dopamine D2 receptor | Q52041433 | ||
| Predicting protein secondary structure with a nearest-neighbor algorithm. | Q52071561 | ||
| Prokink: a protocol for numerical evaluation of helix distortions by proline. | Q52072113 | ||
| Protein sequence alignment techniques. | Q52220839 | ||
| Fold assembly of small proteins using monte carlo simulations driven by restraints derived from multiple sequence alignments. | Q52242283 | ||
| Ligand-induced domain motion in the activation mechanism of a G-protein-coupled receptor. | Q52364896 | ||
| New alignment strategy for transmembrane proteins. | Q52368483 | ||
| P921 | main subject | G protein-coupled receptor | Q38173 |
| P304 | page(s) | 329-371 | |
| P577 | publication date | 2002-01-01 | |
| P1433 | published in | Methods in Enzymology | Q2076903 |
| P1476 | title | Three-dimensional representations of G protein-coupled receptor structures and mechanisms | |
| P478 | volume | 343 |
| Q31004521 | 3D structural model of the G‐protein‐coupled cannabinoid CB2 receptor |
| Q28249697 | A functional selectivity mechanism at the serotonin-2A GPCR involves ligand-dependent conformations of intracellular loop 2 |
| Q24607973 | A microdomain formed by the extracellular ends of the transmembrane domains promotes activation of the G protein-coupled alpha-factor receptor |
| Q39843963 | Accurate prediction of the burial status of transmembrane residues of α-helix membrane protein by incorporating the structural and physicochemical features |
| Q34251407 | Action of molecular switches in GPCRs--theoretical and experimental studies. |
| Q42043872 | Active state-like conformational elements in the beta2-AR and a photoactivated intermediate of rhodopsin identified by dynamic properties of GPCRs |
| Q99357137 | Adaptive evolution of GPR39 in diverse directions in vertebrates |
| Q37578268 | Advances in the Development and Application of Computational Methodologies for Structural Modeling of G-Protein Coupled Receptors. |
| Q35399712 | An olfactory receptor pseudogene whose function emerged in humans: a case study in the evolution of structure-function in GPCRs. |
| Q35925892 | Chemotaxis receptors and signaling |
| Q38155118 | Cholesterol as a co-solvent and a ligand for membrane proteins |
| Q34144314 | Cholesterol modulates the membrane effects and spatial organization of membrane-penetrating ligands for G-protein coupled receptors |
| Q36434064 | Classical transmitters and their receptors in flatworms |
| Q51823568 | Computational study of the heterodimerization between mu and delta receptors. |
| Q35588397 | Conformational changes of G protein-coupled receptors during their activation by agonist binding |
| Q46916180 | Conserved network properties of helical membrane protein structures and its implication for improving membrane protein homology modeling at the twilight zone |
| Q24671760 | Crystal structure of a photoactivated deprotonated intermediate of rhodopsin |
| Q79177476 | Defining the nucleotide binding sites of P2Y receptors using rhodopsin-based homology modeling |
| Q35877995 | Developing a high-quality scoring function for membrane protein structures based on specific inter-residue interactions |
| Q33260986 | Development and application of hybrid structure based method for efficient screening of ligands binding to G-protein coupled receptors |
| Q37073326 | Differential dynamics in the G protein-coupled receptor rhodopsin revealed by solution NMR. |
| Q34049826 | Do crystal structures obviate the need for theoretical models of GPCRs for structure-based virtual screening? |
| Q33825866 | Dynamic models of G-protein coupled receptor dimers: indications of asymmetry in the rhodopsin dimer from molecular dynamics simulations in a POPC bilayer. |
| Q42185342 | Engineering a GPCR-ligand pair that simulates the activation of D(2L) by Dopamine |
| Q30333113 | From subgenome analysis to protein structure. |
| Q22242288 | Functional Selectivity and Classical Concepts of Quantitative Pharmacology |
| Q36440378 | Hallucinogen actions on 5-HT receptors reveal distinct mechanisms of activation and signaling by G protein-coupled receptors |
| Q44434675 | Identification of the binding sites and selectivity of sarpogrelate, a novel 5-HT2 antagonist, to human 5-HT2A, 5-HT2B and 5-HT2C receptor subtypes by molecular modeling |
| Q52013586 | Key issues in the computational simulation of GPCR function: representation of loop domains. |
| Q34244869 | Ligand-dependent conformations and dynamics of the serotonin 5-HT(2A) receptor determine its activation and membrane-driven oligomerization properties |
| Q42916146 | Light activation of rhodopsin: insights from molecular dynamics simulations guided by solid-state NMR distance restraints |
| Q46890983 | Linking agonist binding to histamine H1 receptor activation |
| Q45776913 | Model structures of inactive and peptide agonist bound C5aR: Insights into agonist binding, selectivity and activation |
| Q33647180 | Modeling activated states of GPCRs: the rhodopsin template |
| Q46758094 | Modelling the interaction of catecholamines with the alpha 1A adrenoceptor towards a ligand-induced receptor structure. |
| Q36728991 | Neoceptors: reengineering GPCRs to recognize tailored ligands |
| Q44342096 | Opioid receptor random mutagenesis reveals a mechanism for G protein-coupled receptor activation |
| Q36316851 | Orthogonal activation of the reengineered A3 adenosine receptor (neoceptor) using tailored nucleoside agonists |
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| Q35119322 | Probing the binding site of the A1 adenosine receptor reengineered for orthogonal recognition by tailored nucleosides. |
| Q36776760 | Probing the metabotropic glutamate receptor 5 (mGlu₅) positive allosteric modulator (PAM) binding pocket: discovery of point mutations that engender a "molecular switch" in PAM pharmacology |
| Q34420977 | Probing the structural determinants for the function of intracellular loop 2 in structurally cognate G-protein-coupled receptors |
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| Q36161738 | Purine receptors: GPCR structure and agonist design |
| Q44515852 | Rhodopsin structure: some light into the shadows of retinal degenerations |
| Q44628581 | Selective Interaction of ARF1 with the Carboxy-Terminal Tail Domain of the 5-HT2A Receptor |
| Q35081967 | Sequence analyses of G-protein-coupled receptors: similarities to rhodopsin |
| Q35021290 | Small molecule antagonists of proteins |
| Q33913886 | Structural and dynamic effects of cholesterol at preferred sites of interaction with rhodopsin identified from microsecond length molecular dynamics simulations |
| Q44040777 | Structural mimicry of proline kinks: tertiary packing interactions support local structural distortions. |
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| Q28289039 | Structure-activity relationships of phenylalkylamines as agonist ligands for 5-HT(2A) receptors |
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