Comparative mutagenicity of 7H-dibenzo[c,g]carbazole and two derivatives in MutaMouse liver and skin

scientific article published on 01 September 1998

Comparative mutagenicity of 7H-dibenzo[c,g]carbazole and two derivatives in MutaMouse liver and skin is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S1383-5718(98)00101-6
P698PubMed publication ID9733947

P2093author name stringD Brault
D Renault
V Thybaud
F Périn
F Tombolan
P2860cites workTissue distribution of DNA adducts of 7H-dibenzo[c,g]carbazole and its derivatives in mice following topical application.Q53472590
In vitro metabolism of N-methyl-dibenzo [c,g]carbazole a potent sarcomatogen devoid of hepatotoxic and hepatocarcinogenic properties.Q53553626
Binding of 5,9-dimethyl dibenzo[c,g]carbazole, a potent hepatocarcinogen, to mouse hepatic cytosolic proteins.Q53557795
Heterocyclic polycyclic aromatic hydrocarbon carcinogenesis: 7H-dibenzo[c,g]carbazole metabolism by microsomal enzymes from mouse and rat liverQ53571039
Structure and carcinogenicity of dibenzo(c,g)carbazole derivativesQ68061039
Temporal and molecular characteristics of lacZ mutations in somatic tissues of transgenic miceQ71962905
Initial consideration for use of transgenic mutation assays in a regulatory submissionQ71962938
Carcinogenicity of 7H-dibenzo[c,g]carbazole, dibenz[a,j]acridine and benzo[a]pyrene in mouse skin and liver following topical applicationQ72841661
Tissue-specific differences in adduct formation by hepatocarcinogenic and sarcomatogenic derivatives of 7H-dibenzo[c,g]carbazole in mouse parenchymal and nonparenchymal liver cellsQ73487888
N-methylation reduces the DNA-binding activity of 7H-dibenzo[c,g]carbazole approximately 300-fold in mouse liver but only approximately 2-fold in skin: possible correlation with carcinogenic activityQ23917712
Efficient rescue of integrated shuttle vectors from transgenic mice: a model for studying mutations in vivoQ34312741
Correlation of carcinogenic potency with mouse-skin 32P-postlabeling and muta-Rmouse lac Z− mutation data for DMBA and its K-region sulphur isostere: comparison with activities observed in standard genotoxicity assaysQ36696484
Tissue-specific induction of mutations by acute oral administration of N-methyl-N'-nitro-N-nitrosoguanidine and beta-propiolactone to the Muta Mouse: preliminary data on stomach, liver and bone marrow.Q36801087
Detection of gene mutation in skin, stomach and liver of MutaMouse following oral or topical treatment with N-methyl-N'-nitro-N-nitrosoguanidine or 1-chloromethylpyrene: some preliminary observationsQ38506466
Sodium phenobarbital-enhanced mutation frequency in the liver DNA of lacZ transgenic mice treated with diethylnitrosamineQ39115010
A strategy for establishing mode of action of chemical carcinogens as a guide for approaches to risk assessmentsQ40438417
Cell proliferation as a determining factor for the carcinogenicity of chemicals: studies with mutagenic carcinogens and mutagenic noncarcinogensQ40967410
Comparative carcinogenicity, metabolism, mutagenicity, and DNA binding of 7H-dibenzo[c,g]carbazole and dibenz[a,j]acridineQ41019928
Cancer risk from occupational and environmental exposure to polycyclic aromatic hydrocarbonsQ41719697
Sexual differences in the expression of gamma-glutamyl transpeptidase during 5,9-dimethyldibenzo[c,g]carbazole-induced hepatocarcinogenesis in miceQ41814559
Organ distinctive mutagenicity in MutaMouse after short-term exposure to PhIP.Q42552466
Effect of ethylnitrosourea and methyl methanesulfonate on mutation frequency in Muta Mouse germ cells (seminiferous tubule cells and epididymis spermatozoa).Q43946630
Transgenic lambda/lacI mutagenicity assay: statistical determination of sample sizeQ47357898
Tissue-specific DNA adduct formation in mice treated with the environmental carcinogen, 7H-dibenzo[c,g]carbazoleQ48456853
Organ-specific, carcinogenic dibenzo[c,g]carbazole derivatives: discriminative response in S. typhimurium TA100 mutagenesis modulated by subcellular fractions of mouse liverQ50198349
A preliminary evaluation of the performance of the Muta Mouse (lacZ) and Big Blue (lacI) transgenic mouse mutation assays.Q50771224
Analysis of tissue-specific lacZ mutations induced by N-nitrosodibenzylamine in transgenic mice.Q53439039
DNA adduct formation in primary mouse embryo cells induced by 7H-dibenzo[c,g]carbazole and its organ-specific carcinogenic derivatives.Q53447524
Mutational spectra in the lacl gene in skin from 7,12-dimethylbenz[a]anthracene-treated and untreated transgenic mice.Q53461851
Interaction of 7H-dibenzo[c,g]carbazole and its organspecific derivatives with hepatic mitochondrial and nuclear DNA in the mouse.Q53467598
Comparison of blood protein and target organ DNA and protein binding following topical application of benzo[a]pyrene and 7H-dibenzo[c,g]carbazole to mice.Q53469542
P433issue2-3
P407language of work or nameEnglishQ1860
P304page(s)129-140
P577publication date1998-09-01
P1433published inMutation ResearchQ6943732
P1476titleComparative mutagenicity of 7H-dibenzo[c,g]carbazole and two derivatives in MutaMouse liver and skin
P478volume417

Reverse relations

cites work (P2860)
Q38496305A strong genotoxic effect in mouse skin of a single painting of coal tar in hairless mice and in MutaMouse
Q44220505Clastogenicity of carbazole in mouse bone marrow cells in vivo
Q43825776Comparison of Ha-ras mutational spectra of N-methyldibenzo[c,g]carbazole and 7H-dibenzo[c,g]carbazole-induced mouse skin tumors
Q40494075DNA adduct formation by 7H-dibenzo[c,g]carbazole and its tissue- and organ-specific derivatives in Chinese hamster V79 cell lines stably expressing cytochrome P450 enzymes
Q44411772Genotoxicity of 7H-dibenzo[c,g]carbazole and its tissue-specific derivatives in human hepatoma HepG2 cells is related to CYP1A1/1A2 expression.
Q40815016Induction of micronuclei by 7H-dibenzo[c,g]carbazole and its tissue specific derivatives in Chinese hamster V79MZh1A1 cells
Q40729183Mutagenicity of 7H-dibenzo[c,g]carbazole and its tissue specific derivatives in genetically engineered Chinese hamster V79 cell lines stably expressing cytochrome P450.
Q53729130Properties, environmental fate and biodegradation of carbazole.
Q40855409Role of cytochrome P4501A1 in biotransformation of a tissue specific sarcomagen N-methyldibenzo[c,g]carbazole.
Q38938052Ultraviolet A radiation potentiates the cytotoxic and genotoxic effects of 7 H-dibenzo[c,g]carbazole and its methyl derivatives.

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