Ectodomain cleavage and shedding of the type III transforming growth factor-beta receptor in lung membranes effect of temperature, ligand binding and membrane solubilization

scientific article published on 01 May 1999

Ectodomain cleavage and shedding of the type III transforming growth factor-beta receptor in lung membranes effect of temperature, ligand binding and membrane solubilization is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1046/J.1432-1327.1999.00298.X
P698PubMed publication ID10215877

P2093author name stringR Hannah
A Philip
M O'connor-McCourt
P2860cites workTGF beta signals through a heteromeric protein kinase receptor complexQ24337608
Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sitesQ24673586
Membrane-anchored and soluble forms of betaglycan, a polymorphic proteoglycan that binds transforming growth factor-betaQ24679265
Structure and expression of the membrane proteoglycan betaglycan, a component of the TGF-beta receptor systemQ28304498
Expression cloning and characterization of the TGF-beta type III receptorQ28304515
Cloning of a TGF beta type I receptor that forms a heteromeric complex with the TGF beta type II receptorQ28631183
Control of growth and squamous differentiation in normal human bronchial epithelial cells by chemical and biological modifiers and transferred genesQ35032913
Mapping of the ligand binding domain of the transforming growth factor beta receptor type III by deletion mutagenesisQ35608635
Distribution and modulation of the cellular receptor for transforming growth factor-betaQ36217344
Cytokines. 3. Cytokines in asthmaQ36285841
The beta-type transforming growth factor. Mediators of cell regulation in the lungQ37900029
TGF-beta receptors and actionsQ40753898
Physiological actions and clinical applications of transforming growth factor-beta (TGF-beta).Q40883581
Ligand-dependent and -independent interactions with the transforming growth factor type II and I receptor subunits reside in the aminoterminal portion of the ectodomain of the type III subunitQ41048740
Expression of transforming growth factor beta type III receptor suppresses tumorigenicity of human breast cancer MDA-MB-231 cellsQ41089111
Reconstitution of a pentameric complex of dimeric transforming growth factor beta ligand and a type I, II, III receptor in baculoviral-infected insect cellsQ41193401
Diverse cell surface protein ectodomains are shed by a system sensitive to metalloprotease inhibitors.Q41199229
Characterization of transforming growth factor‐β growth regulatory effects and receptors on bovine mammary cellsQ41277534
Transforming growth factor-beta receptor expression on endothelial cells: heterogeneity of type III receptor expressionQ41291354
Membrane protein secretasesQ41341215
Retinoic acid inhibition of transforming growth factor-beta-induced collagen production by human lung fibroblastsQ41362974
Betaglycan presents ligand to the TGF beta signaling receptor.Q41542611
Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinaseQ41639273
Binding of transforming growth factor-beta to cell surface proteins varies with cell typeQ43778425
A cellular striptease act.Q45072198
Regulation of proliferation and differentiation of respiratory tract epithelial cells by TGF beta.Q51205747
Expression of transforming growth factor-beta 1, -beta 2, and -beta 3 mRNA and protein in the murine lung.Q54235003
Role of the Juxtamembrane Domains of the Transforming Growth Factor-α Precursor and the β-Amyloid Precursor Protein in Regulated Ectodomain SheddingQ58000959
Subtypes of betaglycan and of type I and type II transforming growth factor‐β (TGF‐β) receptors with different affinities for TGF‐β1 and TGF‐β2 are exhibited by human placental trophoblast cellsQ67485868
Mutagenesis analysis of the membrane-proximal ligand binding site of the TGF-beta receptor type III extracellular domainQ70869035
Requirement of transforming growth factor-beta (TGF-beta) type II receptor for TGF-beta-induced proliferation and growth inhibitionQ70937587
Diverse cellular TGF-beta 1 and TGF-beta 3 gene expression in normal human and murine lungQ71939261
Expression of transforming growth factor type III receptor in vascular endothelial cells increases their responsiveness to transforming growth factor beta 2Q72283127
Transforming growth factor-beta 1 (TGF-beta 1)- and beta 2-like activities in malignant pleural effusions caused by malignant mesothelioma or primary lung cancerQ72792646
Collagen synthesis by normal and fibrotic human lung fibroblasts and the effect of transforming growth factor-betaQ93534412
P433issue3
P304page(s)618-628
P577publication date1999-05-01
P1433published inFEBS JournalQ1388041
P1476titleEctodomain cleavage and shedding of the type III transforming growth factor-beta receptor in lung membranes effect of temperature, ligand binding and membrane solubilization
P478volume261

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cites work (P2860)
Q91963152Betaglycan (TβRIII) is a Key Factor in TGF-β2 Signaling in Prepubertal Rat Sertoli Cells
Q43763339Characterization of a 150 kDa accessory receptor for TGF-beta 1 on keratinocytes: direct evidence for a GPI anchor and ligand binding of the released form
Q24338850Identification of CD109 as part of the TGF-beta receptor system in human keratinocytes
Q52206769Mapping of putative binding sites on the ectodomain of the type II TGF-beta receptor by scanning-deletion mutagenesis and knowledge-based modeling.
Q50335740Syndecan-2 regulates transforming growth factor-beta signaling
Q35191593The type III TGF-beta receptor suppresses breast cancer progression
Q42578955The type III TGF-β receptor betaglycan transmembrane-cytoplasmic domain fragment is stable after ectodomain cleavage and is a substrate of the intramembrane protease γ-secretase
Q28198041Real-time monitoring of the interactions of transforming growth factor-beta (TGF-beta ) isoforms with latency-associated protein and the ectodomains of the TGF-beta type II and III receptors reveals different kinetic models and stoichiometries of bi

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