The autonomous transactivation domain in helix H3 of the vitamin D receptor is required for transactivation and coactivator interaction

scientific article published on 01 May 1999

The autonomous transactivation domain in helix H3 of the vitamin D receptor is required for transactivation and coactivator interaction is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.274.20.14352
P698PubMed publication ID10318858

P2093author name stringD M Kraichely
P N MacDonald
J J Collins
R K DeLisle
P2860cites workIsolation and characterization of a novel coactivator protein, NCoA-62, involved in vitamin D-mediated transcriptionQ24308724
GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptorsQ24600501
GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptorsQ24646387
Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acidQ27729334
Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alphaQ27730245
Molecular basis of agonism and antagonism in the oestrogen receptorQ27746278
Atomic structure of progesterone complexed with its receptorQ27758487
Sequence and characterization of a coactivator for the steroid hormone receptor superfamilyQ27860465
The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunitQ27860669
An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptorsQ28280628
The human estrogen receptor has two independent nonacidic transcriptional activation functionsQ29617089
Phosphorylation of E2F-1 modulates its interaction with the retinoblastoma gene product and the adenoviral E4 19 kDa proteinQ34334020
Retinoid X receptors stimulate and 9-cis retinoic acid inhibits 1,25-dihydroxyvitamin D3-activated expression of the rat osteocalcin geneQ36702240
Human vitamin D receptor is selectively phosphorylated by protein kinase C on serine 51, a residue crucial to its trans-activation functionQ37610022
AF-2 activity and recruitment of steroid receptor coactivator 1 to the estrogen receptor depend on a lysine residue conserved in nuclear receptorsQ38347273
A role for helix 3 of the TRbeta ligand-binding domain in coactivator recruitment identified by characterization of a third cluster of mutations in resistance to thyroid hormoneQ41015780
Nuclear receptor coactivators and corepressorsQ41447637
Purified human vitamin D receptor overexpressed in E. coli and baculovirus systems does not bind 1,25-dihydroxyvitamin D3 hormone efficiently unless supplemented with a rat liver nuclear extract.Q41508525
Mutations in the 1,25-dihydroxyvitamin D3 receptor identifying C-terminal amino acids required for transcriptional activation that are functionally dissociated from hormone binding, heterodimeric DNA binding, and interaction with basal transcriptionQ42439013
Nuclear receptor-binding sites of coactivators glucocorticoid receptor interacting protein 1 (GRIP1) and steroid receptor coactivator 1 (SRC-1): multiple motifs with different binding specificitiesQ46744802
A structural role for hormone in the thyroid hormone receptor.Q46828407
Hormone-dependent coactivator binding to a hydrophobic cleft on nuclear receptorsQ46828991
Transcriptional activation through the vitamin D receptor in osteoblasts.Q47774510
Characterization of the Amino-terminal Transcriptional Activation Function of the Human Estrogen Receptor in Animal and Yeast CellsQ57849120
A canonical structure for the ligand-binding domain of nuclear receptorsQ61818643
A highly conserved region in the hormone-binding domain of the human estrogen receptor functions as an efficient transactivation domain in yeastQ72525080
Nuclear receptor coactivatorsQ73153183
P433issue20
P407language of work or nameEnglishQ1860
P304page(s)14352-14358
P577publication date1999-05-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe autonomous transactivation domain in helix H3 of the vitamin D receptor is required for transactivation and coactivator interaction
P478volume274

Reverse relations

cites work (P2860)
Q30755130A functionally conserved member of the FTZ-F1 nuclear receptor family from Schistosoma mansoni
Q31943130Central role of VDR conformations for understanding selective actions of vitamin D(3) analogues
Q40802857Functionally relevant polymorphisms in the human nuclear vitamin D receptor gene
Q43676067Model of three-dimensional structure of vitamin D receptor and its binding mechanism with 1alpha,25-dihydroxyvitamin D(3).
Q28548633Novel Vitamin D Receptor Mutations in Hereditary Vitamin D Resistant Rickets in Chinese
Q24306801Nuclear coactivator-62 kDa/Ski-interacting protein is a nuclear matrix-associated coactivator that may couple vitamin D receptor-mediated transcription and RNA splicing
Q38643135Relationship between Structure and Conformational Change of the Vitamin D Receptor Ligand Binding Domain in 1α,25-Dihydroxyvitamin D3 Signaling.
Q44025388Stabilization of androgen receptor protein is induced by agonist, not by antagonists
Q24291587Ternary complexes and cooperative interplay between NCoA-62/Ski-interacting protein and steroid receptor coactivators in vitamin D receptor-mediated transcription
Q22253412The human transcription factor IID subunit human TATA-binding protein-associated factor 28 interacts in a ligand-reversible manner with the vitamin D(3) and thyroid hormone receptors
Q40413870Transrepression by a liganded nuclear receptor via a bHLH activator through co-regulator switching
Q31943081Vitamin D receptor and nuclear receptor coactivators: crucial interactions in vitamin D-mediated transcription
Q35025290Vitamin D receptor and retinoid X receptor interactions in motion

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