Activation of heterocyclic amines by combinations of prostaglandin H synthase-1 and -2 with N-acetyltransferase 1 and 2

scientific article published on 01 November 1998

Activation of heterocyclic amines by combinations of prostaglandin H synthase-1 and -2 with N-acetyltransferase 1 and 2 is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0304-3835(98)00217-1
P8608Fatcat IDrelease_qqttfvmbkvcdljwgcdxzxrfjz4
P698PubMed publication ID9929169

P2093author name stringY Liu
G N Levy
P2860cites workCarcinogenicity of 2-Amino-3-methylimidazo[4,5-f]quinoline in Nonhuman Primates: Induction of Tumors in Three MacaquesQ55100996
Effect of cooking methods on the mutagenicity of food and on urinary mutagenicity of human consumersQ60692597
Detection and measurement of MeIQx in human urine after ingestion of a cooked meat mealQ69579692
Species differences in the N-acetylation by liver cytosol of mutagenic heterocyclic aromatic amines in protein pyrolysatesQ71350665
Activation of 2-aminofluorene by prostaglandin endoperoxide H synthase-2Q71780914
Metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) by human cytochrome P4501B1Q73781579
Human P3(450): cDNA and complete amino acid sequenceQ24611916
Human arylamine N-acetyltransferase genes: isolation, chromosomal localization, and functional expressionQ28116125
Metabolic activation of carcinogenic heterocyclic aromatic amines by human liver and colonQ28609945
Heterocyclic amines: evaluation of their role in diet associated human cancerQ36093689
Bacterial mutagenicity of heterocyclic amines found in heat-processed foodQ38715312
SEMV cell cultures: a model for studies of prostaglandin-H synthase-mediated metabolism and genotoxicity of xenobioticsQ40885673
Differential effect of acetyltransferase expression on the genotoxicity of heterocyclic amines in CHO cellsQ41115182
N-and O-acetylation of aromatic and heterocyclic amine carcinogens by human monomorphic and polymorphic acetyltransferases expressed in COS-1 cellsQ41618193
Cytochrome P450 forms in the rodent lung involved in the metabolic activation of food-derived heterocyclic aminesQ42289116
Induction of human prostaglandin endoperoxide H synthase-2 (PHS-2) mRNA by TCDD.Q42550812
Kinetics of arylamine N-acetyltransferase in tissues from rapid and slow acetylator miceQ44762100
Human hepatic CYP1A1 and CYP1A2 content, determined with specific anti-peptide antibodies, correlates with the mutagenic activation of PhIP.Q46472830
Bioactivation of 2-amino-3-methylimidazo[4,5-f] quinoline (IQ) by prostaglandin H synthaseQ50131773
Metabolic activation of heterocyclic aromatic amines catalyzed by human arylamine N-acetyltransferase isozymes (NAT1 and NAT2) expressed in Salmonella typhimuriumQ50144786
Prostaglandin-H synthase mediated metabolism and mutagenic activation of 2-amino-3-methylimidazo [4,5-f] quinoline (IQ).Q50145935
Prostaglandin H synthase-dependent mutagenic activation of heterocyclic aromatic amines of the IQ-typeQ50201561
Carcinogenicity of mutagenic heterocyclic amines formed during the cooking processQ50205714
Metabolic activation and DNA binding of food mutagens and other environmental carcinogens in human mammary epithelial cells.Q53452314
Presence of N2-(deoxyguanosin-8-yl)-2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (dG-C8-MeIQx) in human tissues.Q53454859
The role of the human acetylation polymorphism in the metabolic activation of the food carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)Q53487110
2-Aminofluorene-DNA adducts in mouse urinary bladder: effect of age, sex and acetylator phenotype.Q53492389
Xenobiotic biotransformation in livestock: comparison to other species commonly used in toxicity testing.Q53886701
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)115-123
P577publication date1998-11-01
P1433published inCancer LettersQ326372
P1476titleActivation of heterocyclic amines by combinations of prostaglandin H synthase-1 and -2 with N-acetyltransferase 1 and 2
P478volume133

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cites work (P2860)
Q50120880Bioactivation of the food mutagen 2-amino-3-methyl-imidazo[4, 5-f]quinoline (IQ) by prostaglandin-H synthase and by monooxygenases: DNA adduct analysis
Q28373841Comparison of three different in vitro mutation assays used for the investigation of cytochrome P450-mediated mutagenicity of nitro-polycyclic aromatic hydrocarbons
Q51770836Human prostaglandin H synthase (hPHS)-1- and hPHS-2-dependent bioactivation, oxidative macromolecular damage, and cytotoxicity of dopamine, its precursor, and its metabolites
Q73250269N-acetyltransferase 2 (NAT2) genotype and colorectal carcinoma: risk variability according to tumour site?
Q33689052N-acetyltransferase 2 activity and folate levels
Q54652081Only low levels of exogenous N-acetyltransferase can be achieved in transgenic mice.
Q39371037Synthesis and biological evaluation of novel benzothiazole-2-thiol derivatives as potential anticancer agents.

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