Acyl-coenzyme A:cholesterol acyltransferase inhibitor, avasimibe, stimulates bile acid synthesis and cholesterol 7alpha-hydroxylase in cultured rat hepatocytes and in vivo in the rat

scientific article published on 01 August 1999

Acyl-coenzyme A:cholesterol acyltransferase inhibitor, avasimibe, stimulates bile acid synthesis and cholesterol 7alpha-hydroxylase in cultured rat hepatocytes and in vivo in the rat is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/HEP.510300230
P698PubMed publication ID10421659

P50authorHans M PrincenQ57299407
Mettine BosQ78045277
P2093author name stringF Kuipers
R Havinga
J P Zoeteweij
S M Post
E C de Wit
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Cafestol, the cholesterol-raising factor in boiled coffee, suppresses bile acid synthesis by downregulation of cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase in rat hepatocytesQ28578676
Effect of Biliary Drainage on Individual Reactions in the Conversion of Cholesterol to Taurocholic Acid. Bile Acids and Steroids 180Q34054626
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Dietary cholesterol and downregulation of cholesterol 7 alpha-hydroxylase and cholesterol absorption in African green monkeysQ34150907
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Disruption of cholesterol 7alpha-hydroxylase gene in mice. II. Bile acid deficiency is overcome by induction of oxysterol 7alpha-hydroxylase.Q35671417
Regulation of cholesterol metabolism in the dog. I. Effects of complete bile diversion and of cholesterol feeding on absorption, synthesis, accumulation, and excretion rates measured during lifeQ35899910
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Secretion of Cholesterol-Rich Lipoproteins by Perfused Livers of Hypercholesterolemic RatsQ40239048
Unexpected inhibition of cholesterol 7 alpha-hydroxylase by cholesterol in New Zealand white and Watanabe heritable hyperlipidemic rabbits.Q40342532
Ketoconazole blocks bile acid synthesis in hepatocyte monolayer cultures and in vivo in rat by inhibiting cholesterol 7 alpha-hydroxylaseQ40919334
Hepatic ACAT activity in African green monkeys is highly correlated to plasma LDL cholesteryl ester enrichment and coronary artery atherosclerosisQ41098772
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Cyclosporin A blocks bile acid synthesis in cultured hepatocytes by specific inhibition of chenodeoxycholic acid synthesisQ42023326
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Cellular free cholesterol in Hep G2 cells is only partially available for down-regulation of low-density-lipoprotein receptor activityQ42164591
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Effect of lymphatic drainage on 7alpha-hydroxylation of cholesterol in rat liverQ67435250
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Potential bile acid precursors in plasma--possible indicators of biosynthetic pathways to cholic and chenodeoxycholic acids in manQ68562278
The role of acyl-CoA: cholesterol acyltransferase in the metabolism of free cholesterol to cholesteryl esters or bile acids in primary cultures of rat hepatocytesQ69052301
Altered lipid metabolism in apolipoprotein E-deficient mice does not affect cholesterol balance across the liverQ71257654
Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. CI-1011: an acyl sulfamate with unique cholesterol-lowering activity in animals fed noncholesterol-supplemented dietsQ71935042
Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 6. The first water-soluble ACAT inhibitor with lipid-regulating activityQ72289344
Regulation of hepatic 7 alpha-hydroxylase expression and response to dietary cholesterol in the rat and hamsterQ72631412
ACAT inhibitor HL-004 accelerates the regression of hypercholesterolemia in stroke-prone spontaneously hypertensive rats (SHRSP): stimulation of bile acid production by HL-004Q73589925
Increased bile acid pool inhibits cholesterol 7 alpha-hydroxylase in cholesterol-fed rabbitsQ73933606
CI-1011 lowers lipoprotein(a) and plasma cholesterol concentrations in chow-fed cynomolgus monkeysQ74449512
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)491-500
P577publication date1999-08-01
P1433published inHepatologyQ15724398
P1476titleAcyl-coenzyme A:cholesterol acyltransferase inhibitor, avasimibe, stimulates bile acid synthesis and cholesterol 7alpha-hydroxylase in cultured rat hepatocytes and in vivo in the rat
P478volume30

Reverse relations

cites work (P2860)
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Q28115475Decreased Expression of ARV1 Results in Cholesterol Retention in the Endoplasmic Reticulum and Abnormal Bile Acid Metabolism*
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Q24648243Inhibition of acyl-coenzyme A:cholesterol acyltransferase stimulates cholesterol efflux from macrophages and stimulates farnesoid X receptor in hepatocytes
Q45712469Intracellular mechanisms mediating the inhibition of apoB-containing lipoprotein synthesis and secretion in HepG2 cells by avasimibe (CI-1011), a novel acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor
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Q39841745Signaling through cholesterol esterification: a new pathway for the cholecystokinin 2 receptor involved in cell growth and invasion
Q64119960The APOE3-Leiden Heterozygous Glucokinase Knockout Mouse as Novel Translational Disease Model for Type 2 Diabetes, Dyslipidemia, and Diabetic Atherosclerosis

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