Crystal and molecular structure of 2-hydroxy-1-naphthaldehyde isonicotinoyl hydrazone (NIH) and its iron(III) complex: an iron chelator with anti-tumour activity

scientific article published on 01 June 1999

Crystal and molecular structure of 2-hydroxy-1-naphthaldehyde isonicotinoyl hydrazone (NIH) and its iron(III) complex: an iron chelator with anti-tumour activity is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1015774486
P356DOI10.1007/S007750050312
P698PubMed publication ID10439071

P50authorDes R. RichardsonQ37369291
Paul V BernhardtQ57159160
P433issue3
P304page(s)266-273
P577publication date1999-06-01
P1433published inJournal of Biological Inorganic ChemistryQ3186899
P1476titleCrystal and molecular structure of 2-hydroxy-1-naphthaldehyde isonicotinoyl hydrazone (NIH) and its iron(III) complex: an iron chelator with anti-tumour activity
P478volume4

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cites work (P2860)
Q40938234(E)-4-{2-[(2-Hy-droxy-naphthalen-1-yl)methyl-idene]hydrazinecarbon-yl}pyridinium nitrate.
Q423893393-Bromo-N'-(2-hydr-oxy-3,5-diiodo-benzyl-idene)benzohydrazide monohydrate
Q35075541A class of iron chelators with a wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics
Q28392750Cellular iron depletion and the mechanisms involved in the iron-dependent regulation of the growth arrest and DNA damage family of genes
Q88735261Coupling of the polyamine and iron metabolism pathways in the regulation of proliferation: Mechanistic links to alterations in key polyamine biosynthetic and catabolic enzymes
Q44621428Cytotoxic iron chelators: characterization of the structure, solution chemistry and redox activity of ligands and iron complexes of the di-2-pyridyl ketone isonicotinoyl hydrazone (HPKIH) analogues
Q35927265Decoupling Activation of Heme Biosynthesis from Anaerobic Toxicity in a Molecule Active in Staphylococcus aureus
Q40918044Development of novel aroylhydrazone ligands for iron chelation therapy: 2-pyridylcarboxaldehyde isonicotinoyl hydrazone analogs
Q36557412Differential targeting of the cyclin-dependent kinase inhibitor, p21CIP1/WAF1, by chelators with anti-proliferative activity in a range of tumor cell-types
Q37367609Hydrogen peroxide triggered prochelator activation, subsequent metal chelation, and attenuation of the fenton reaction
Q35045012Identification of the di-pyridyl ketone isonicotinoyl hydrazone (PKIH) analogues as potent iron chelators and anti-tumour agents
Q40645757Interactions of the pyridine-2-carboxaldehyde isonicotinoyl hydrazone class of chelators with iron and DNA: implications for toxicity in the treatment of iron overload disease
Q36143645Iron chelators ICL670 and 311 inhibit HIV-1 transcription
Q34671614Iron chelators as therapeutic agents for the treatment of cancer.
Q34313287Isomerization/Recyclization of some 5-Ethoxycarbonyl-pyrimidines
Q33534491Lipophilic aroylhydrazone chelator HNTMB and its multiple effects on ovarian cancer cells
Q42161606N'-(2-Methoxy-benzyl-idene)-2-nitro-benzo-hydrazide
Q34600331N-myc downstream regulated 1 (NDRG1) is regulated by eukaryotic initiation factor 3a (eIF3a) during cellular stress caused by iron depletion.
Q42872726New class of potent antitumor acylhydrazone derivatives containing furan
Q40367516Novel diaroylhydrazine ligands as iron chelators: coordination chemistry and biological activity.
Q44264337Pyridoxal isonicotinoyl hydrazone analogs induce apoptosis in hematopoietic cells due to their iron-chelating properties
Q41349934Sirtuin inhibitor sirtinol is an intracellular iron chelator.
Q47262014Small Molecule Chelators Reveal That Iron Starvation Inhibits Late Stages of Bacterial Cytokinesis.
Q40214951Synthesis and Characterization of Cr(III), Mn(III), Fe(III), VO(IV), Zr(IV) and UO2(VI) Complexes of Schiff Base Derived from Isonicotinoyl Hydrazone
Q40468331Synthesis and antibacterial activity of novel 5,6,7,8-tetrahydroimidazo[1,2-a]pyrimidine-2-carbohydrazide derivatives.
Q38873252Synthesis, characterization and biological evaluation of transition metal complexes derived from N, S bidentate ligands.
Q40075530Tuning the antiproliferative activity of biologically active iron chelators: characterization of the coordination chemistry and biological efficacy of 2-acetylpyridine and 2-benzoylpyridine hydrazone ligands
Q47165634Zwitterionic 1-{(1E)-[(4-hy-droxy-phen-yl)iminio]meth-yl}naphthalen-2-olate: crystal structure and Hirshfeld surface analysis

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