Analysis of heparin-binding sites in human lipoprotein lipase using synthetic peptides

scientific article published on 01 November 1998

Analysis of heparin-binding sites in human lipoprotein lipase using synthetic peptides is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1021976212
P356DOI10.1023/A:1020730418999
P698PubMed publication ID9988527

P2093author name stringM Uddin
O U Beg
A R Siddiqi
P2860cites workLipoprotein lipaseBethesda: a single amino acid substitution (Ala-176----Thr) leads to abnormal heparin binding and loss of enzymic activityQ28115882
The carboxyl-terminal domain of lipoprotein lipase binds to the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor (LRP) and mediates binding of normal very low density lipoproteins to LRP.Q34291365
Mutagenesis in four candidate heparin binding regions (residues 279-282, 291-304, 390-393, and 439-448) and identification of residues affecting heparin binding of human lipoprotein lipaseQ34319402
A carboxyl-terminal fragment of lipoprotein lipase binds to the low density lipoprotein receptor-related protein and inhibits lipase-mediated uptake of lipoprotein in cells.Q34327500
Molecular genetics of human lipoprotein lipase deficiencyQ35797235
The sequence of cDNA encoding lipoprotein lipase. A member of a lipase gene familyQ36467720
Heparin- and sulfatide-binding peptides from the type I repeats of human thrombospondin promote melanoma cell adhesionQ36934814
Glycosaminoglycans: molecular properties, protein interactions, and role in physiological processesQ37671601
Oligosaccharide sequences of endothelial cell surface heparan sulfate proteoglycan with affinity for lipoprotein lipaseQ38304522
Site-directed mutagenesis of a putative heparin binding domain of avian lipoprotein lipase.Q38321662
Lipoprotein lipase. A multifunctional enzyme relevant to common metabolic diseasesQ38611172
Effects of gene mutations in lipoprotein and hepatic lipases as interpreted by a molecular model of the pancreatic triglyceride lipaseQ41143549
Binding to heparan sulfate is a major event during catabolism of lipoprotein lipase by HepG2 and other cell culturesQ41351176
Binding of lipoprotein lipase to heparin. Identification of five critical residues in two distinct segments of the amino-terminal domain.Q41559003
Interaction of lipoprotein lipase with native and modified heparin-like polysaccharidesQ42177560
Identification and characterization of the endothelial cell surface lipoprotein lipase receptorQ42463105
Lipoprotein lipase. Molecular model based on the pancreatic lipase x-ray structure: consequences for heparin binding and catalysisQ42612557
Insulin regulation of lipoprotein lipase activity in 3T3-L1 adipocytes is mediated at posttranscriptional and posttranslational levelsQ42798253
Chimeras of hepatic lipase and lipoprotein lipase. Domain localization of enzyme-specific propertiesQ44497545
Human lipoprotein lipase. Analysis of the catalytic triad by site-directed mutagenesis of Ser-132, Asp-156, and His-241Q44585592
Heparin-binding peptides from the type I repeats of thrombospondin. Structural requirements for heparin binding and promotion of melanoma cell adhesion and chemotaxis.Q44731571
Molecular modeling of protein-glycosaminoglycan interactions.Q52546742
Structural and functional roles of highly conserved serines in human lipoprotein lipase. Evidence that serine 132 is essential for enzyme catalysis.Q53842484
Identification of two separate allelic mutations in the lipoprotein lipase gene of a patient with the familial hyperchylomicronemia syndromeQ67678122
Catalytic triad residue mutation (Asp156----Gly) causing familial lipoprotein lipase deficiency. Co-inheritance with a nonsense mutation (Ser447----Ter) in a Turkish familyQ67993962
A peptide model for the heparin binding site of antithrombin IIIQ68064206
Binding of lipoprotein lipase to endothelial cells in cultureQ71006547
Mutation of tryptophan residues in lipoprotein lipase. Effects on stability, immunoreactivity, and catalytic propertiesQ71973560
P4510describes a project that usessynthetic peptideQ104631433
P433issue8
P304page(s)807-815
P577publication date1998-11-01
P1433published inThe Protein JournalQ15760422
P1476titleAnalysis of heparin-binding sites in human lipoprotein lipase using synthetic peptides
P478volume17

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cites work (P2860)
Q28744283Comparative studies of vertebrate lipoprotein lipase: a key enzyme of very low density lipoprotein metabolism
Q38317248Matrix-embedded cytokines to simulate osteoarthritis-like cartilage microenvironments
Q37584881The metabolism of triglyceride-rich lipoproteins revisited: new players, new insight

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