A RhoGEF and Rho family GTPase-activating protein complex links the contractile ring to cortical microtubules at the onset of cytokinesis

scientific article published on 01 January 2003

A RhoGEF and Rho family GTPase-activating protein complex links the contractile ring to cortical microtubules at the onset of cytokinesis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S1534-5807(02)00402-1
P698PubMed publication ID12530961

P50authorRobert SaintQ47503411
P2093author name stringW Gregory Somers
P2860cites workRac function and regulation during Drosophila development.Q52122073
Mutations affecting the pattern of the larval cuticle inDrosophila melanogaster : II. Zygotic loci on the third chromosomeQ89559824
MgcRacGAP is involved in cytokinesis through associating with mitotic spindle and midbodyQ24290538
Central spindle assembly and cytokinesis require a kinesin-like protein/RhoGAP complex with microtubule bundling activityQ24292120
CHO1, a mammalian kinesin-like protein, interacts with F-actin and is involved in the terminal phase of cytokinesisQ24673339
Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesisQ24681007
CYK-4: A Rho family gtpase activating protein (GAP) required for central spindle formation and cytokinesisQ24685960
Rho GTPases and the actin cytoskeletonQ27860579
Rac/Cdc42 and p65PAK regulate the microtubule-destabilizing protein stathmin through phosphorylation at serine 16Q28142648
mDia mediates Rho-regulated formation and orientation of stable microtubulesQ28210597
The role of RhoA in tissue polarity and Frizzled signallingQ28238365
Cooperation between mDia1 and ROCK in Rho-induced actin reorganizationQ28587275
A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchbackQ29618324
Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeletonQ29620156
Identification of a new family of tissue-specific basic helix-loop-helix proteins with a two-hybrid systemQ29620436
Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways.Q30169019
Molecular dissection of cytokinesis by RNA interference in Drosophila cultured cellsQ33893773
Rac GTPases control axon growth, guidance and branchingQ34120933
Animal cell cytokinesisQ34425177
MgcRacGAP, a new human GTPase-activating protein for Rac and Cdc42 similar to Drosophila rotundRacGAP gene product, is expressed in male germ cellsQ34459816
The pebble GTP exchange factor and the control of cytokinesis.Q34593575
pavarotti encodes a kinesin-like protein required to organize the central spindle and contractile ring for cytokinesisQ35200561
Rho guanosine triphosphatase mediates the selective stabilization of microtubules induced by lysophosphatidic acidQ36255290
The small GTP-binding protein rho regulates cortical activities in cultured cells during divisionQ36255734
Midzone microtubule bundles are continuously required for cytokinesis in cultured epithelial cellsQ36256911
Cytokinesis and midzone microtubule organization in Caenorhabditis elegans require the kinesin-like protein ZEN-4.Q36895980
Signals from the spindle midzone are required for the stimulation of cytokinesis in cultured epithelial cellsQ37379600
A putative exchange factor for Rho1 GTPase is required for initiation of cytokinesis in Drosophila.Q40445021
Coordination of microtubules and the actin cytoskeleton by the Rho effector mDia1.Q43516733
Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeleton.Q47070036
Biochemical studies of the mechanism of action of the Cdc42-GTPase-activating proteinQ47954738
P433issue1
P1104number of pages11
P304page(s)29-39
P577publication date2003-01-01
P1433published inDevelopmental CellQ1524277
P1476titleA RhoGEF and Rho family GTPase-activating protein complex links the contractile ring to cortical microtubules at the onset of cytokinesis
P478volume4

Reverse relations

cites work (P2860)
Q91767686A Cyclin A-Myb-MuvB-Aurora B network regulates the choice between mitotic cycles and polyploid endoreplication cycles
Q42370101A GAP that Divides
Q30478155A PI3K activity-independent function of p85 regulatory subunit in control of mammalian cytokinesis
Q30301325A complex of p190RhoGAP-A and anillin modulates RhoA-GTP and the cytokinetic furrow in human cells
Q40926682A dynamic microtubule cytoskeleton directs medial actomyosin function during tube formation
Q36320722A microtubule-dependent zone of active RhoA during cleavage plane specification
Q33863246A mitotic kinesin-6, Pav-KLP, mediates interdependent cortical reorganization and spindle dynamics in Drosophila embryos
Q30578547A spindle-independent cleavage furrow positioning pathway.
Q91648650A unique kinesin-like protein, Klp8, is involved in mitosis and cell morphology through microtubule stabilization
Q24321392ARF6 GTPase protects the post-mitotic midbody from 14-3-3-mediated disintegration
Q33589990Action at a distance during cytokinesis
Q47771119Active Ran regulates anillin function during cytokinesis
Q89588240Adherens junction remodelling during mitotic rounding of pseudostratified epithelial cells
Q24315633An ECT2-centralspindlin complex regulates the localization and function of RhoA
Q30484371An agent-based model contrasts opposite effects of dynamic and stable microtubules on cleavage furrow positioning
Q34238787An anillin-Ect2 complex stabilizes central spindle microtubules at the cortex during cytokinesis
Q30607531An astral simulacrum of the central spindle accounts for normal, spindle-less, and anucleate cytokinesis in echinoderm embryos
Q38313030An essential role of Cdc42-like GTPases in mitosis of HeLa cells
Q34419568An integrated overview of spatiotemporal organization and regulation in mitosis in terms of the proteins in the functional supercomplexes.
Q30842564Analysis of mouse germ-cell transcriptome at different stages of spermatogenesis by SAGE: biological significance.
Q36247435Anillin Phosphorylation Controls Timely Membrane Association and Successful Cytokinesis.
Q30480058Astral signals spatially bias cortical myosin recruitment to break symmetry and promote cytokinesis
Q30661930Asymmetrically dividing Drosophila neuroblasts utilize two spatially and temporally independent cytokinesis pathways
Q27306243Augmin shapes the anaphase spindle for efficient cytokinetic furrow ingression and abscission
Q34948243Aurora B but not rho/MLCK signaling is required for localization of diphosphorylated myosin II regulatory light chain to the midzone in cytokinesis
Q27314778Aurora B kinase promotes cytokinesis by inducing centralspindlin oligomers that associate with the plasma membrane
Q42092748Binding of the CYK-4 subunit of the centralspindlin complex induces a large scale conformational change in the kinesin subunit.
Q41831270CUX1 and E2F1 regulate coordinated expression of the mitotic complex genes Ect2, MgcRacGAP, and MKLP1 in S phase.
Q33632440CYK-4 regulates Rac, but not Rho, during cytokinesis
Q30524671CYK4 inhibits Rac1-dependent PAK1 and ARHGEF7 effector pathways during cytokinesis
Q27312358CYK4 promotes antiparallel microtubule bundling by optimizing MKLP1 neck conformation
Q28255939Cdk1-dependent mitotic enrichment of cortical myosin II promotes cell rounding against confinement
Q38028782Cell cycle regulation of Rho signaling pathways
Q41930709Cell division: the need for speed
Q30528961Cell elongation is an adaptive response for clearing long chromatid arms from the cleavage plane
Q37412642Cellular symmetry breaking during Caenorhabditis elegans development
Q37588868Centralspindlin and chromosomal passenger complex behavior during normal and Rappaport furrow specification in echinoderm embryos
Q37611553Centralspindlin and α-catenin regulate Rho signalling at the epithelial zonula adherens
Q41716058Centralspindlin assembly and 2 phosphorylations on MgcRacGAP by Polo-like kinase 1 initiate Ect2 binding in early cytokinesis
Q50672837Centralspindlin is required for thorax development during Drosophila metamorphosis.
Q24305873Centralspindlin links the mitotic spindle to the plasma membrane during cytokinesis
Q27014502Centralspindlin: at the heart of cytokinesis
Q24314527Centrosome/spindle pole-associated protein regulates cytokinesis via promoting the recruitment of MyoGEF to the central spindle
Q24670163Cep55, a microtubule-bundling protein, associates with centralspindlin to control the midbody integrity and cell abscission during cytokinesis
Q34294435Changes in Ect2 localization couple actomyosin-dependent cell shape changes to mitotic progression
Q24301126Characterization of centrosomal proteins Cep55 and pericentrin in intercellular bridges of mouse testes
Q35599103Chlamydia trachomatis inclusions induce asymmetric cleavage furrow formation and ingression failure in host cells
Q35646477Cleavage furrow positioning
Q35116282Closing the GAP: a role for a RhoA GAP in cytokinesis
Q24624139Clustering of centralspindlin is essential for its accumulation to the central spindle and the midbody
Q29615212Conserved microtubule-actin interactions in cell movement and morphogenesis
Q27334688Conserved roles for cytoskeletal components in determining laterality
Q38257062Controlling the switches: Rho GTPase regulation during animal cell mitosis
Q30480760Cooperative assembly of CYK-4/MgcRacGAP and ZEN-4/MKLP1 to form the centralspindlin complex
Q24301484Crystal structure of triple-BRCT-domain of ECT2 and insights into the binding characteristics to CYK-4
Q42428994Cytokinesis in Drosophila male meiosis.
Q38034201Cytokinesis in Drosophila melanogaster
Q35245324Cytokinesis in animal cells
Q34300588Cytokinesis microtubule organisers at a glance
Q33917647Cytokinesis proteins Tum and Pav have a nuclear role in Wnt regulation
Q35195261Cytokinesis: a logical GAP.
Q51843299Cytokinesis: mind the GAP.
Q42064531Cytokinetic astralogy
Q37416384Cytoskeletal remodeling during myotube assembly and guidance: coordinating the actin and microtubule networks
Q34481329Direct interaction between centralspindlin and PRC1 reinforces mechanical resilience of the central spindle
Q35119295Dispatch. Cell division: the place and time of cytokinesis.
Q42741736Dissecting protein interactions during cytokinesis
Q24338658Dissecting the role of Rho-mediated signaling in contractile ring formation
Q30476131Distinct pathways control recruitment and maintenance of myosin II at the cleavage furrow during cytokinesis.
Q37595315Drosophila citron kinase is required for the final steps of cytokinesis.
Q37213455Drosophila embryonic cell-cycle mutants
Q37342479Dynamics of myosin, microtubules, and Kinesin-6 at the cortex during cytokinesis in Drosophila S2 cells.
Q24337741Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis
Q41374143Ect2/Pbl acts via Rho and polarity proteins to direct the assembly of an isotropic actomyosin cortex upon mitotic entry
Q33928692Function and regulation of Tumbleweed (RacGAP50C) in neuroblast proliferation and neuronal morphogenesis
Q30480028GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases
Q33693699Genetic dissection of meiotic cytokinesis in Drosophila males.
Q34537585Genetic evidence for antagonism between Pak protein kinase and Rho1 small GTPase signaling in regulation of the actin cytoskeleton during Drosophila oogenesis
Q47072115Heterologous expression of mammalian Plk1 in Drosophila reveals divergence from Polo during late mitosis.
Q35060075Identification of novel Ras-cooperating oncogenes in Drosophila melanogaster: a RhoGEF/Rho-family/JNK pathway is a central driver of tumorigenesis
Q55416346Identifying Genetic Players in Cell Sheet Morphogenesis Using a Drosophila Deficiency Screen for Genes on Chromosome 2R Involved in Dorsal Closure.
Q37329172Inhibition of Rac by the GAP activity of centralspindlin is essential for cytokinesis
Q37303350Inhibition of Rac1 GTPase activity affects porcine oocyte maturation and early embryo development
Q92709483Interaction of microtubules and actin during the post-fusion phase of exocytosis
Q34989257Isoform-specific functions of Mud/NuMA mediate binucleation of Drosophila male accessory gland cells.
Q24301784KIF14 and citron kinase act together to promote efficient cytokinesis
Q46299972Linking spindle to furrow.
Q36124969Localization of Pavarotti-KLP in living Drosophila embryos suggests roles in reorganizing the cortical cytoskeleton during the mitotic cycle.
Q52668776Mechanical forces drive neuroblast morphogenesis and are required for epidermal closure.
Q35804823Mechanics and regulation of cytokinesis
Q36825263Mechanisms of CDC-42 activation during contact-induced cell polarization
Q34348551Mechanisms of contractile-ring assembly in fission yeast and beyond
Q24318853MgcRacGAP controls the assembly of the contractile ring and the initiation of cytokinesis
Q33811939MgcRacGAP interacts with cingulin and paracingulin to regulate Rac1 activation and development of the tight junction barrier during epithelial junction assembly
Q30664623MgcRacGAP restricts active RhoA at the cytokinetic furrow and both RhoA and Rac1 at cell-cell junctions in epithelial cells
Q64236761Microtubule plus-ends act as physical signaling hubs to activate RhoA during cytokinesis
Q38152747Microtubules and actin crosstalk in cell migration and division
Q50709997Modeling cytokinesis of eukaryotic cells driven by the actomyosin contractile ring.
Q39183594Modular regulation of Rho family GTPases in development.
Q35952748Multiple parallelisms in animal cytokinesis.
Q42915467Mutations in orbit/mast reveal that the central spindle is comprised of two microtubule populations, those that initiate cleavage and those that propagate furrow ingression.
Q36322042Mutations in sticky lead to defective organization of the contractile ring during cytokinesis and are enhanced by Rho and suppressed by Rac
Q41504158Myosin efflux promotes cell elongation to coordinate chromosome segregation with cell cleavage.
Q35760258N-terminal kinesins: many and various.
Q34439714Nessun Dorma, a novel centralspindlin partner, is required for cytokinesis in Drosophila spermatocytes
Q26777135New Auroras on the Roles of the Chromosomal Passenger Complex in Cytokinesis: Implications for Cancer Therapies
Q38177408New insights into the molecular mechanisms of mitosis and cytokinesis in trypanosomes
Q27346295Orbit/CLASP is required for myosin accumulation at the cleavage furrow in Drosophila male meiosis
Q47163564Overexpression of epithelial cell transforming 2 protein in colorectal carcinoma predicts a poor prognosis.
Q30512426PRC1 controls spindle polarization and recruitment of cytokinetic factors during monopolar cytokinesis
Q27316679Pavarotti/MKLP1 regulates microtubule sliding and neurite outgrowth in Drosophila neurons.
Q37358734Pebble/ECT2 RhoGEF negatively regulates the Wingless/Wnt signaling pathway.
Q24306750Phosphoregulation of MgcRacGAP in mitosis involves Aurora B and Cdk1 protein kinases and the PP2A phosphatase
Q24317964Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis
Q28818796Plasma Membrane Association but Not Midzone Recruitment of RhoGEF ECT2 Is Essential for Cytokinesis
Q21563540Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells
Q30541406Polarity in migrating neurons is related to a mechanism analogous to cytokinesis
Q30496569Polo kinase interacts with RacGAP50C and is required to localize the cytokinesis initiation complex.
Q26825016Polo-like kinase 1, on the rise from cell cycle regulation to prostate cancer development
Q47782037Prepatterning by RhoGEFs governs Rho GTPase spatiotemporal dynamics during wound repair.
Q39658732Progressive loss of RacGAP1/ogre activity has sequential effects on cytokinesis and zebrafish development
Q37171995RacGAP50C directs perinuclear gamma-tubulin localization to organize the uniform microtubule array required for Drosophila myotube extension
Q34572773RacGap50C negatively regulates wingless pathway activity during Drosophila embryonic development.
Q42915287Rappaport furrows on our minds: the ASCB Cytokinesis Meeting Burlington, VT July 22-25, 2004.
Q27302949Recruitment of Polo kinase to the spindle midzone during cytokinesis requires the Feo/Klp3A complex
Q27332449Redundant mechanisms recruit actin into the contractile ring in silkworm spermatocytes
Q58555874Regulating a key mitotic regulator, Polo-like Kinase 1 (PLK1)
Q47072777Regulation of Drosophila mesoderm migration by phosphoinositides and the PH domain of the Rho GTP exchange factor Pebble.
Q30439337Regulation of cytokinesis by Rho GTPase flux
Q30487793Regulation of the Rac GTPase pathway by the multifunctional Rho GEF Pebble is essential for mesoderm migration in the Drosophila gastrula.
Q28265366Rho GTPase activity zones and transient contractile arrays
Q34160731Rho GTPases as regulators of mitosis and cytokinesis in mammalian cells
Q38050708Rho GTPases in animal cell cytokinesis: an occupation by the one percent
Q36404878Rho-dependent control of anillin behavior during cytokinesis.
Q92540505Rho-dependent control of the Citron kinase, Sticky, drives midbody ring maturation
Q37891679Rho-guanine nucleotide exchange factors during development: Force is nothing without control
Q24685128Rho-kinase controls cell shape changes during cytokinesis
Q37244908RhoGEF and positioning of rappaport-like furrows in the early Drosophila embryo
Q35340567Role of Survivin in cytokinesis revealed by a separation-of-function allele
Q24561647Role of the midbody matrix in cytokinesis: RNAi and genetic rescue analysis of the mammalian motor protein CHO1.
Q30512382Roles of putative Rho-GEF Gef2 in division-site positioning and contractile-ring function in fission yeast cytokinesis
Q43210731SHCBP1 is required for midbody organization and cytokinesis completion
Q26851587Single cell pattern formation and transient cytoskeletal arrays
Q30494581Small molecules discovered in a pathway screen target the Rho pathway in cytokinesis
Q43722646Spatio-temporally separated cortical flows and spindle geometry establish physical asymmetry in fly neural stem cells
Q64882149Spatiotemporal Regulation of RhoA during Cytokinesis.
Q36429848Spindle Assembly and Chromosome Segregation Requires Central Spindle Proteins in Drosophila Oocytes
Q28083790Splitting the cell, building the organism: Mechanisms of cell division in metazoan embryos
Q39829616Stabilization of anaphase midzone microtubules is regulated by Rho during cytokinesis in human fibrosarcoma cells.
Q30484369Stable and dynamic microtubules coordinately shape the myosin activation zone during cytokinetic furrow formation
Q37781881Still entangled: Assembly of the central spindle by multiple microtubule modulators
Q33488378Targeted gain-of-function screening in Drosophila using GAL4-UAS and random transposon insertions
Q30495347Terminal cytokinesis events uncovered after an RNAi screen
Q24296867The 3M complex maintains microtubule and genome integrity
Q24645077The 3Ms of central spindle assembly: microtubules, motors and MAPs
Q34360670The Caenorhabditis elegans ect-2 RhoGEF gene regulates cytokinesis and migration of epidermal P cells
Q98771702The Mechanics of Mitotic Cell Rounding
Q48303069The MgcRacGAP SxIP motif tethers Centralspindlin to microtubule plus ends in Xenopus laevis.
Q35773765The RhoGAP domain of CYK-4 has an essential role in RhoA activation
Q37863400The diverse roles of Rac signaling in tumorigenesis
Q33827549The guanine nucleotide exchange factor (GEF) Ect2 is an oncogene in human cancer
Q34049742The kinesinlike protein Subito contributes to central spindle assembly and organization of the meiotic spindle in Drosophila oocytes
Q24315138The tandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesis
Q36744955Transcriptome Profiling Following Neuronal and Glial Expression of ALS-Linked SOD1 in Drosophila
Q27321152Tum/RacGAP functions as a switch activating the Pav/kinesin-6 motor
Q34717820Understanding Cytokinesis Failure
Q30482088Vesicles and actin are targeted to the cleavage furrow via furrow microtubules and the central spindle
Q34194546What Drosophila spermatocytes tell us about the mechanisms underlying cytokinesis
Q30833306p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis
Q24672210p190RhoGAP is cell cycle regulated and affects cytokinesis
Q30436244p190RhoGAP negatively regulates Rho activity at the cleavage furrow of mitotic cells.

Search more.