Fluid shear stress-induced transcriptional activation of the vascular endothelial growth factor receptor-2 gene requires Sp1-dependent DNA binding

scientific article published on 01 January 2003

Fluid shear stress-induced transcriptional activation of the vascular endothelial growth factor receptor-2 gene requires Sp1-dependent DNA binding is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0014-5793(02)03879-6
P698PubMed publication ID12560084

P50authorStefanie DimmelerQ110856
Carmen UrbichQ86379417
Kerstin Bianca ReisingerQ97652666
Jens GilleQ115360311
P2093author name stringRoland Kaufmann
Monika Stein
P2860cites workActivation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylationQ22010150
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nucleiQ27860728
Angiogenesis in cancer and other diseasesQ27861015
Signaling via vascular endothelial growth factor receptorsQ28139029
Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in miceQ28504776
High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesisQ28594191
Vascular-specific growth factors and blood vessel formationQ29614780
The role of mechanical stresses in microvascular remodelingQ30469299
Systemic hypoxia changes the organ-specific distribution of vascular endothelial growth factor and its receptorsQ33615441
Targeting vascular endothelial growth factor (VEGF) for anti-tumor therapy, by anti-VEGF neutralizing monoclonal antibodies or by VEGF receptor tyrosine-kinase inhibitorsQ33944191
The controls of microvascular survivalQ34146385
Cloning and functional analysis of the promoter for KDR/flk-1, a receptor for vascular endothelial growth factorQ36681701
Sequence-specific recognition of DNA by zinc-finger peptides derived from the transcription factor Sp1Q37252624
Hypoxia-induced paracrine regulation of vascular endothelial growth factor receptor expressionQ37350460
Downregulation of vascular endothelial growth factor receptors by tumor necrosis factor-alpha in cultured human vascular endothelial cellsQ37357812
Shear stress induction of the tissue factor geneQ37363474
Upregulation of TRAF-3 by shear stress blocks CD40-mediated endothelial activationQ38294592
Transcription factors Sp1 and Sp3 alter vascular endothelial growth factor receptor expression through a novel recognition sequenceQ38335452
Transforming growth factor beta 1 down-regulates vascular endothelial growth factor receptor 2/flk-1 expression in vascular endothelial cells.Q38357881
Increased gene expression for VEGF and the VEGF receptors KDR/Flk and Flt in lungs exposed to acute or to chronic hypoxia. Modulation of gene expression by nitric oxideQ40342883
Transforming growth factor-beta 1-mediated inhibition of the flk-1/KDR gene is mediated by a 5'-untranslated region palindromic GATA siteQ40839613
Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia.Q41091104
Intracellular pH and tyrosine phosphorylation but not calcium determine shear stress-induced nitric oxide production in native endothelial cellsQ42517024
Shear stress induces expression of vascular endothelial growth factor receptor Flk-1/KDR through the CT-rich Sp1 binding siteQ44030291
Homologous up-regulation of KDR/Flk-1 receptor expression by vascular endothelial growth factor in vitro.Q46035889
Regulation of vascular endothelial growth factor receptor-2 (Flk-1) expression in vascular endothelial cells.Q47935183
Vascular endothelial growth factor (VEGF) and VEGF receptor 2 (flk-1) are expressed during vasculogenesis and vascular differentiation in the quail embryo.Q48073084
Induction of human vascular endothelial stress fibres by fluid shear stressQ59063741
Molecular regulation of angiogenesis in the skinQ71001756
Nuclear protein interactions with the human KDR/flk-1 promoter in vivo. Regulation of Sp1 binding is associated with cell type-specific expressionQ73174604
Receptor chimeras indicate that the vascular endothelial growth factor receptor-1 (VEGFR-1) modulates mitogenic activity of VEGFR-2 in endothelial cellsQ73626313
Fractal characteristics of tumor vascular architecture during tumor growth and regressionQ74051314
Fluid shear stress stimulates phosphorylation of Akt in human endothelial cells: involvement in suppression of apoptosisQ77114860
P433issue1-3
P304page(s)87-93
P577publication date2003-01-01
P1433published inFEBS LettersQ1388051
P1476titleFluid shear stress-induced transcriptional activation of the vascular endothelial growth factor receptor-2 gene requires Sp1-dependent DNA binding
P478volume535

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cites work (P2860)
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