Binding interaction of quercetin-3-beta-galactoside and its synthetic derivatives with SARS-CoV 3CL(pro): structure-activity relationship studies reveal salient pharmacophore features

scientific article published on 12 October 2006

Binding interaction of quercetin-3-beta-galactoside and its synthetic derivatives with SARS-CoV 3CL(pro): structure-activity relationship studies reveal salient pharmacophore features is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.BMC.2006.09.014
P932PMC publication ID7125754
P698PubMed publication ID17046271

P50authorXu-Rui ShenQ88324943
Weijun XuQ56768311
P2093author name stringLili Chen
Hong Liu
Gang Chen
Jian Li
Hualiang Jiang
Cheng Luo
Weiliang Zhu
Chum Mok Puah
Oi Wah Liew
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Reduced progression of atherosclerosis in apolipoprotein E-deficient mice following consumption of red wine, or its polyphenols quercetin or catechin, is associated with reduced susceptibility of LDL to oxidation and aggregationQ42448586
Food-derived polyphenols inhibit pancreatic cancer growth through mitochondrial cytochrome C release and apoptosisQ43938062
A 3D model of SARS_CoV 3CL proteinase and its inhibitors design by virtual screening.Q44468486
Dissection study on the severe acute respiratory syndrome 3C-like protease reveals the critical role of the extra domain in dimerization of the enzyme: defining the extra domain as a new target for design of highly specific protease inhibitorsQ44511959
Molecular cloning, expression, purification, and mass spectrometric characterization of 3C-like protease of SARS coronavirusQ44765532
3C-like proteinase from SARS coronavirus catalyzes substrate hydrolysis by a general base mechanismQ44839752
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Quercetin, a bioflavonoid, attenuates ferric nitrilotriacetate-induced oxidative renal injury in ratsQ44937276
High-throughput screening identifies inhibitors of the SARS coronavirus main proteinaseQ45110672
Characterization of SARS-CoV main protease and identification of biologically active small molecule inhibitors using a continuous fluorescence-based assay.Q45118974
Severe acute respiratory syndrome coronavirus 3C-like proteinase N terminus is indispensable for proteolytic activity but not for enzyme dimerization. Biochemical and thermodynamic investigation in conjunction with molecular dynamics simulationsQ45126666
Mechanism of the maturation process of SARS-CoV 3CL proteaseQ46402178
Effects of chronic quercetin treatment in experimental renovascular hypertensionQ46405592
Screening of drugs by FRET analysis identifies inhibitors of SARS-CoV 3CL proteaseQ46540496
Anti-SARS coronavirus 3C-like protease effects of Isatis indigotica root and plant-derived phenolic compounds.Q46663447
Binding mechanism of coronavirus main proteinase with ligands and its implication to drug design against SARS.Q51661127
Synthesis of Novel 3,7-Substituted-2-(3‘,4‘-dihydroxyphenyl)flavones with Improved Antioxidant ActivityQ61959403
[Isolation of hyperoside (quercetin-3-D-galactoside) from Rumex acetosa]Q78677717
P433issue24
P407language of work or nameEnglishQ1860
P921main subjectSARS-CoV-1Q85438966
P304page(s)8295-8306
P577publication date2006-10-12
P1433published inBioorganic & Medicinal ChemistryQ2904200
P1476titleBinding interaction of quercetin-3-beta-galactoside and its synthetic derivatives with SARS-CoV 3CL(pro): structure-activity relationship studies reveal salient pharmacophore features
P478volume14

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