KIT oncoprotein interactions in gastrointestinal stromal tumors: therapeutic relevance

scientific article published on 23 April 2007

KIT oncoprotein interactions in gastrointestinal stromal tumors: therapeutic relevance is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1029805632
P356DOI10.1038/SJ.ONC.1210464
P698PubMed publication ID17452978

P2093author name stringDemetri GD
Fletcher CD
Cohen PS
Fletcher JA
Zhu MJ
Ou WB
P2860cites workUse of signal specific receptor tyrosine kinase oncoproteins reveals that pathways downstream from Grb2 or Shc are sufficient for cell transformation and metastasisQ24292477
Formation of signal transfer complexes between stem cell and platelet-derived growth factor receptors and SH2 domain proteins in vitroQ24306912
Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumors.Q27824798
Gain-of-function mutations of c-kit in human gastrointestinal stromal tumorsQ28118852
Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathwaysQ28274882
The kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136Q28275577
Interaction of the receptor tyrosine kinase p145c-kit with the p210bcr/abl kinase in myeloid cellsQ28286939
Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumorsQ29618610
Cell proliferation through forced engagement of c-Kit and Flt-3.Q33947825
PDGFRA activating mutations in gastrointestinal stromal tumors.Q34169772
Biology and genetic aspects of gastrointestinal stromal tumors: KIT activation and cytogenetic alterations.Q34524914
Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: randomised trialQ34551403
Cell-to-cell adhesion modulates Stat3 activity in normal and breast carcinoma cellsQ40580990
STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: biological and clinical implicationsQ40783216
Signal transducer and activator of transcription 3 activation is required for Asp(816) mutant c-Kit-mediated cytokine-independent survival and proliferation in human leukemia cellsQ43615388
Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs).Q44790860
KIT-negative gastrointestinal stromal tumors: proof of concept and therapeutic implicationsQ44956779
Protein Kinase C theta (PKCtheta) expression and constitutive activation in gastrointestinal stromal tumors (GISTs).Q45003972
Mechanisms of resistance to imatinib mesylate in gastrointestinal stromal tumors and activity of the PKC412 inhibitor against imatinib-resistant mutantsQ45247236
P433issue44
P304page(s)6386-6395
P577publication date2007-04-23
P1433published inOncogeneQ1568657
P1476titleKIT oncoprotein interactions in gastrointestinal stromal tumors: therapeutic relevance
P478volume26